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Search Results to Brooke Fridley

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One or more keywords matched the following properties of Fridley, Brooke

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research overview Dr. Fridley joined Children’s Mercy in December of 2023 as the Director of the Biostatistics and Epidemiology Core within the Division of Health Services and Outcomes Research. She is also Professor of Pediatrics at the University of Missouri – Kansas City and is a member of the University of Kansas Cancer Center (KUCC). Before joining Children’s Mercy, she was the Chair of the Department of Biostatistics and Bioinformatics and Scientific Director for the CCSG Biostatistics and Bioinformatics Shared Resource at Moffitt Cancer Center in Tampa, FL. She has extensive experience as a collaborating biostatistician and has worked on numerous cancer research studies over the course of her career. These research collaborations have resulted in over 290 publications and 6 NIH grants for which she was Principal Investigator. She also has extensive experience mentoring trainees and was MPI of a T32 entitled “Integrative Program in Cancer and Data Science” from NIH/NCI. The Fridley lab is focused on development of novel statistical and bioinformatic methods to answer questions that arise in cancer research. Recently, her lab has been working on analytical methods for understanding the spatial architecture of the tumor immune microenvironment and how this is related to clinical outcomes by leveraging the information from spatial single-cell protein and spatial transcriptomic experiments.

One or more keywords matched the following items that are connected to Fridley, Brooke

Item TypeName
Concept Protein Binding
Concept Tumor Suppressor Protein p53
Concept Protein Structure, Tertiary
Concept Calcium-Calmodulin-Dependent Protein Kinases
Concept BRCA1 Protein
Concept Protein Subunits
Concept BRCA2 Protein
Concept Ubiquitin-Protein Ligases
Concept Protein Kinase Inhibitors
Concept CASP8 and FADD-Like Apoptosis Regulating Protein
Concept Calcium-Calmodulin-Dependent Protein Kinase Type 2
Concept Nephroblastoma Overexpressed Protein
Concept Transcription Factor 7-Like 2 Protein
Concept Death-Associated Protein Kinases
Academic Article Clinical characteristics of ovarian cancer classified by BRCA1, BRCA2, and RAD51C status.
Academic Article The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population.
Academic Article Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
Academic Article Genome-wide association analysis identified splicing single nucleotide polymorphism in CFLAR predictive of triptolide chemo-sensitivity.
Academic Article Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer.
Academic Article Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer.
Academic Article Clinical and Emergent Biomarkers and Their Relationship to the Prognosis of Ovarian Cancer.
Academic Article PPM1D Mosaic Truncating Variants in Ovarian Cancer Cases May Be Treatment-Related Somatic Mutations.
Academic Article Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.
Academic Article PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.
Academic Article Metformin pharmacogenomics: a genome-wide association study to identify genetic and epigenetic biomarkers involved in metformin anticancer response using human lymphoblastoid cell lines.
Academic Article Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.
Academic Article Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer.
Academic Article Differential roles of ERRFI1 in EGFR and AKT pathway regulation affect cancer proliferation.
Academic Article Patterns and predictors of genetic referral among ovarian cancer patients at a National Cancer Institute-Comprehensive Cancer Center.
Academic Article Statistical analysis of single-cell protein data.
Academic Article Human phenylethanolamine N-methyltransferase genetic polymorphisms and exercise-induced epinephrine release.
Academic Article No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer.
Academic Article Inherited variants in mitochondrial biogenesis genes may influence epithelial ovarian cancer risk.
Academic Article Genetic variation predicting cisplatin cytotoxicity associated with overall survival in lung cancer patients receiving platinum-based chemotherapy.
Academic Article Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development.
Academic Article Common variation in Nemo-like kinase is associated with risk of ovarian cancer.
Academic Article Survival is associated with genetic variation in inflammatory pathway genes among patients with resected and unresected pancreatic cancer.
Academic Article TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression.

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