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Fridley, Brooke

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Dr. Fridley joined Children’s Mercy in December of 2023 as the Director of the Biostatistics and Epidemiology Core within the Division of Health Services and Outcomes Research. She is also Professor of Pediatrics at the University of Missouri – Kansas City and is a member of the University of Kansas Cancer Center (KUCC). Before joining Children’s Mercy, she was the Chair of the Department of Biostatistics and Bioinformatics and Scientific Director for the CCSG Biostatistics and Bioinformatics Shared Resource at Moffitt Cancer Center in Tampa, FL. She has extensive experience as a collaborating biostatistician and has worked on numerous cancer research studies over the course of her career. These research collaborations have resulted in over 290 publications and 6 NIH grants for which she was Principal Investigator. She also has extensive experience mentoring trainees and was MPI of a T32 entitled “Integrative Program in Cancer and Data Science” from NIH/NCI. The Fridley lab is focused on development of novel statistical and bioinformatic methods to answer questions that arise in cancer research. Recently, her lab has been working on analytical methods for understanding the spatial architecture of the tumor immune microenvironment and how this is related to clinical outcomes by leveraging the information from spatial single-cell protein and spatial transcriptomic experiments.

One or more keywords matched the following items that are connected to Fridley, Brooke

Item Type	Name
Concept	Carrier Proteins
Concept	Chromosomal Proteins, Non-Histone
Concept	Cytoskeletal Proteins
Concept	DNA-Binding Proteins
Concept	Heat-Shock Proteins
Concept	Membrane Proteins
Concept	Microfilament Proteins
Concept	Neoplasm Proteins
Concept	Nerve Tissue Proteins
Concept	Nuclear Proteins
Concept	Protein Binding
Concept	Proteins
Concept	Proto-Oncogene Proteins
Concept	Repressor Proteins
Concept	Oncogene Proteins
Concept	Oncogene Proteins, Fusion
Concept	Tumor Suppressor Protein p53
Concept	Proto-Oncogene Proteins p21(ras)
Concept	RNA-Binding Proteins
Concept	Protein Structure, Tertiary
Concept	Calcium-Calmodulin-Dependent Protein Kinases
Concept	Homeodomain Proteins
Concept	ras Proteins
Concept	Cell Cycle Proteins
Concept	BRCA1 Protein
Concept	Monomeric GTP-Binding Proteins
Concept	Proto-Oncogene Proteins c-myb
Concept	I-kappa B Proteins
Concept	T-Box Domain Proteins
Concept	Protein Subunits
Concept	Tacrolimus Binding Proteins
Concept	Mitochondrial Proteins
Concept	BRCA2 Protein
Concept	Tumor Suppressor Proteins
Concept	Membrane Transport Proteins
Concept	Multidrug Resistance-Associated Proteins
Concept	Drosophila Proteins
Concept	Telomere-Binding Proteins
Concept	Ubiquitin-Protein Ligases
Concept	Protein Kinase Inhibitors
Concept	Intracellular Signaling Peptides and Proteins
Concept	Adaptor Proteins, Signal Transducing
Concept	Suppressor of Cytokine Signaling Proteins
Concept	Apoptosis Regulatory Proteins
Concept	Proto-Oncogene Proteins c-akt
Concept	Proto-Oncogene Proteins c-mdm2
Concept	Fanconi Anemia Complementation Group Proteins
Concept	CASP8 and FADD-Like Apoptosis Regulating Protein
Concept	CARD Signaling Adaptor Proteins
Concept	Calcium-Calmodulin-Dependent Protein Kinase Type 2
Concept	A Kinase Anchor Proteins
Concept	Nephroblastoma Overexpressed Protein
Concept	Transcription Factor 7-Like 2 Protein
Concept	5-Lipoxygenase-Activating Proteins
Concept	Ataxia Telangiectasia Mutated Proteins
Concept	Death-Associated Protein Kinases
Academic Article	Bayseian genomic models for the incorporation of pathway topology knowledge into association studies.
Academic Article	Contribution of FKBP5 genetic variation to gemcitabine treatment and survival in pancreatic adenocarcinoma.
Academic Article	Integrative gene set analysis: application to platinum pharmacogenomics.
Academic Article	Clinical characteristics of ovarian cancer classified by BRCA1, BRCA2, and RAD51C status.
Academic Article	The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population.
Academic Article	Genome-wide investigation of regional blood-based DNA methylation adjusted for complete blood counts implicates BNC2 in ovarian cancer.
Academic Article	Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33.
Academic Article	Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk.
Academic Article	Genetic variation in platinating agent and taxane pathway genes as predictors of outcome and toxicity in advanced non-small-cell lung cancer.
Academic Article	Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk.
Academic Article	Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
Academic Article	No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.
Academic Article	Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk.
Academic Article	Genome-wide association analysis identified splicing single nucleotide polymorphism in CFLAR predictive of triptolide chemo-sensitivity.
Academic Article	Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk.
Academic Article	Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.
Academic Article	Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer.
Academic Article	Cross Cancer Genomic Investigation of Inflammation Pathway for Five Common Cancers: Lung, Ovary, Prostate, Breast, and Colorectal Cancer.
Academic Article	Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer.
Academic Article	Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer.
Academic Article	Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.
Academic Article	Clinical and Emergent Biomarkers and Their Relationship to the Prognosis of Ovarian Cancer.
Academic Article	PPM1D Mosaic Truncating Variants in Ovarian Cancer Cases May Be Treatment-Related Somatic Mutations.
Academic Article	Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer.
Academic Article	Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk.
Academic Article	Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.
Academic Article	PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.
Academic Article	Metformin pharmacogenomics: a genome-wide association study to identify genetic and epigenetic biomarkers involved in metformin anticancer response using human lymphoblastoid cell lines.
Academic Article	Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.
Academic Article	Characterization of fusion genes in common and rare epithelial ovarian cancer histologic subtypes.
Academic Article	Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer.
Academic Article	Gene Expression, and Fatigue in Puerto Rican Men during Radiotherapy for Prostate Cancer: an Exploratory Study.
Academic Article	Expression of Sestrin Genes in Radiotherapy for Prostate Cancer and Its Association With Fatigue: A Proof-of-Concept Study.
Academic Article	Differential roles of ERRFI1 in EGFR and AKT pathway regulation affect cancer proliferation.
Academic Article	Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility.
Academic Article	Assessment of ASC specks as a putative biomarker of pyroptosis in myelodysplastic syndromes: an observational cohort study.
Academic Article	rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology.
Academic Article	Patterns and predictors of genetic referral among ovarian cancer patients at a National Cancer Institute-Comprehensive Cancer Center.
Academic Article	Identification of Two Genetic Loci Associated with Leukopenia after Chemotherapy in Patients with Breast Cancer.
Academic Article	Statistical analysis of single-cell protein data.
Academic Article	Interacting alleles of the coinhibitory immunoreceptor genes cytotoxic T-lymphocyte antigen 4 and programmed cell-death 1 influence risk and features of primary biliary cirrhosis.
Academic Article	Human phenylethanolamine N-methyltransferase genetic polymorphisms and exercise-induced epinephrine release.
Academic Article	Proteasome beta subunit pharmacogenomics: gene resequencing and functional genomics.
Academic Article	Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk.
Academic Article	Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer.
Academic Article	Polymorphisms in NF-kappaB inhibitors and risk of epithelial ovarian cancer.
Academic Article	No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer.
Academic Article	FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt.
Academic Article	ESR1/SYNE1 polymorphism and invasive epithelial ovarian cancer risk: an Ovarian Cancer Association Consortium study.
Academic Article	A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.
Academic Article	Common variants at 19p13 are associated with susceptibility to ovarian cancer.
Academic Article	Ecto-5'-nucleotidase and thiopurine cellular circulation: association with cytotoxicity.
Academic Article	Genome-wide association analyses of genetic, phenotypic, and environmental risks in the age-related eye disease study.
Academic Article	The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing.
Academic Article	Mycophenolic acid response biomarkers: a cell line model system-based genome-wide screen.
Academic Article	Inherited variants in mitochondrial biogenesis genes may influence epithelial ovarian cancer risk.
Academic Article	LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer.
Academic Article	Genetic variation predicting cisplatin cytotoxicity associated with overall survival in lung cancer patients receiving platinum-based chemotherapy.
Academic Article	Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development.
Academic Article	Common variation in Nemo-like kinase is associated with risk of ovarian cancer.
Academic Article	Ovarian cancer risk associated with inherited inflammation-related variants.
Academic Article	SSBP2 variants are associated with survival in glioblastoma patients.
Academic Article	Identification of a novel percent mammographic density locus at 12q24.
Academic Article	A low-frequency variant at 8q24.21 is strongly associated with risk of oligodendroglial tumors and astrocytomas with IDH1 or IDH2 mutation.
Academic Article	FKBP5 genetic variation: association with selective serotonin reuptake inhibitor treatment outcomes in major depressive disorder.
Academic Article	Survival is associated with genetic variation in inflammatory pathway genes among patients with resected and unresected pancreatic cancer.
Academic Article	TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression.

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GTP Binding Proteins