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Leeder, J. Steven

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item Type	Name
Concept	Genotype
Academic Article	Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations.
Academic Article	Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans.
Academic Article	CYP2D6 poor metabolizer status can be ruled out by a single genotyping assay for the -1584G promoter polymorphism.
Academic Article	Discovery of a novel nonfunctional cytochrome P450 2D6 allele, CYP2D642, in African American subjects.
Academic Article	Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".
Academic Article	Comparison of various urine collection intervals for caffeine and dextromethorphan phenotyping in children.
Academic Article	Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension.
Academic Article	Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans.
Academic Article	Variability of CYP3A7 expression in human fetal liver.
Academic Article	CYP2D7 splice variants in human liver and brain: does CYP2D7 encode functional protein?
Academic Article	Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail.
Academic Article	CYP2D636 gene arrangements within the cyp2d6 locus: association of CYP2D636 with poor metabolizer status.
Academic Article	Comments on Hoskins et al. [(2005) drug metab dispos 33:1564-1565].
Academic Article	Variability of CYP2J2 expression in human fetal tissues.
Academic Article	Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother.
Academic Article	Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events.
Academic Article	Ontogeny of dextromethorphan O- and N-demethylation in the first year of life.
Academic Article	Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype.
Academic Article	The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype.
Academic Article	Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study.
Academic Article	Evaluation of a [13C]-dextromethorphan breath test to assess CYP2D6 phenotype.
Academic Article	CYP2D7-2D6 hybrid tandems: identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction.
Academic Article	Impact of the CYP2C19*17 allele on the pharmacokinetics of omeprazole and pantoprazole in children: evidence for a differential effect.
Academic Article	The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response.
Academic Article	Betaine-homocysteine methyltransferase: human liver genotype-phenotype correlation.
Academic Article	Identifying genomic and developmental causes of adverse drug reactions in children.
Academic Article	Development of biomarkers to optimize pediatric patient management: what makes children different?
Academic Article	CYP2D6, SULT1A1 and UGT2B17 copy number variation: quantitative detection by multiplex PCR.
Academic Article	High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6.
Academic Article	Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity.
Academic Article	Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.
Academic Article	VKORC1 and CYP2C9 genotypes are predictors of warfarin-related outcomes in children.
Academic Article	Effect of CYP3A5 genotype, steroids, and azoles on tacrolimus in a pediatric renal transplant population.
Academic Article	Individualizing the use of medications in children: making Goldilocks happy.
Academic Article	CYP2D6 and pharmacogenomics: where does future research need to focus? Part 2: clinical aspects.
Academic Article	SNP genotyping using TaqMan technology: the CYP2D6*17 assay conundrum.
Academic Article	Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing.
Academic Article	Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors.
Academic Article	Variability in Expression of CYP3A5 in Human Fetal Liver.
Academic Article	CYP2D6 Haplotype Determination Using Long Range Allele-Specific Amplification: Resolution of a Complex Genotype and a Discordant Genotype Involving the CYP2D6*59 Allele.
Academic Article	Single dose, CYP2D6 genotype-stratified pharmacokinetic study of atomoxetine in children with ADHD.
Academic Article	Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.
Academic Article	Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics.
Academic Article	Prediction of CYP2D6 phenotype from genotype across world populations.
Academic Article	Chiral phase analysis of warfarin enantiomers in patient plasma in relation to CYP2C9 genotype.
Academic Article	NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations.
Academic Article	Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping.
Academic Article	Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs.
Academic Article	Quantification of intraindividual variability and the influence of menstrual cycle phase on CYP2D6 activity as measured by dextromethorphan phenotyping.
Academic Article	Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.
Academic Article	Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.
Academic Article	Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.
Academic Article	Age- and Genotype-Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate-Glucuronosyltransferases in Human Liver.
Academic Article	Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data.
Academic Article	Limitations of dextromethorphan N-demethylation as a measure of CYP3A activity.
Academic Article	Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".
Academic Article	Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity.
Academic Article	Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.
Academic Article	A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents.
Academic Article	A systematic approach to implementing monogenic genomic medicine: Genotype-driven diagnosis of genetic diseases
Academic Article	Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy.
Academic Article	Analysis Approaches to Identify Pharmacogenetic Associations With Pharmacodynamics.
Academic Article	The Impact of the CYP2D6 "Enhancer" Single Nucleotide Polymorphism on CYP2D6 Activity.
Academic Article	Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants.
Academic Article	SLCO1B1 Genetic Variation Influence on Atorvastatin Systemic Exposure in Pediatric Hypercholesterolemia.

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