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Statin Optimization in Pediatrics
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abstract
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Major Goals: 1) Determine the role of gastric acid on the formation of 3a-PVA and the functional consequences of 3a-PVA on PVA transport. 2) Develop and validate a PBPK model of pravastatin in children and adolescents from planned and existing biotransformation and pharmacogenomics studies to optimize statin therapy in children.
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label
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Statin Optimization in Pediatrics
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