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Search Results to Taeju Park

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One or more keywords matched the following properties of Park, Taeju

PropertyValue
keywords New Drug Development
keywords Brain Development
research overview Dr. Park’s study is focused on two proteins – Crk and CrkL – that are reported to be elevated in several types of human cancer, including glioblastoma, and correlated with poor prognosis. Tumor cell migration and invasion contribute to the spread of glioblastoma to healthy brain tissues, leading to high recurrence rates. Dr. Park has established the real-time quantitative measurement of glioma cell migration upon gene knockdown or overexpression and demonstrated that Crk and CrkL play important roles in glioblastoma cell migration and invasion. Dr. Park is also working on the potential role of Crk and CrkL in diffuse intrinsic pontine glioma (DIPG) cell migration and invasion. In addition, Dr. Park is working to develop specific inhibitors of these proteins to block glioblastoma and DIPG cell migration and invasion. In the lab, Dr. Park and his team take advantage of genetically engineered mouse models and the gene knockdown and overexpression technique to study tumorigenic functions of Crk and CrkL. They identified a protein that is activated by elevated Crk and CrkL and binds to Crk and CrkL. The new malignant connection promotes tumor cell migration and invasion. Dr. Park’s goal is to develop drugs that specifically break down the aberrant protein-protein complex between Crk and CrkL and their binding partners. To test the effects of chemical compounds on the binding of these proteins, Dr. Park developed in vitro assay systems and conducted a high-throughput screen. In partnership with the University of Kansas Cancer Center, the team has tested 200,000 chemical compounds and identified more than 600 potential candidate drugs. These compounds are undergoing rigorous post-screening validation using different biochemical experiments. They will continue to expand productive collaboration with KU core facilities to discover novel anticancer drugs. They are optimizing a new quadruple screening to discover inhibitors of both SH2 and SH3 domains of Crk and CrkL. The newly developed inhibitors will be used to advance studies of cancer and other human diseases in which Crk and CrkL play essential roles. Dr. Park also collaborates with multiple core facility directors at the University of Kansas and the Univesity of Kansas Medical Center and has established a multidisciplinary research team for the structure-function relationship study. His team has developed Crk/CrkL-antagonist peptides that bind to the SH2 domains of Crk and CrkL and inhibit Crk/CrkL-mediated protein-protein interactions. Previously, Dr. Park generated mutant mice lacking both Crk and CrkL in the developing brain and demonstrated that Crk and CrkL play essential overlapping functions in neuronal migration during brain development. Recently, genomic analysis of a patient with a severe global developmental delay and ataxia identified two new mutations in Crk and another protein that may interact with Crk. His team generated two mutant mouse strains harboring the two mutations and plan to study individual and combined contributions of the two genes to brain development. These phenotyping results will provide essential knowledge for understanding both the underlying mechanism of the clinical deficits and the signaling pathways in brain development, therefore laying the foundation for developing therapeutic interventions.

One or more keywords matched the following items that are connected to Park, Taeju

Item TypeName
Concept Acetylcholine
Concept Adenosine
Concept Cyclic AMP
Concept Adenosine Triphosphate
Concept Adenylyl Cyclases
Concept Adrenergic alpha-Agonists
Concept Adrenergic alpha-Antagonists
Concept Adrenergic beta-Agonists
Concept Alkenes
Concept Amitriptyline
Concept Anesthetics, Local
Concept Anti-Infective Agents, Local
Concept Anti-Bacterial Agents
Concept Antidepressive Agents, Tricyclic
Concept Antihypertensive Agents
Concept Arylamine N-Acetyltransferase
Concept Binding Sites
Concept Bradykinin
Concept Calcium
Concept Calcium Channel Blockers
Concept Camphor
Concept Carbachol
Concept Catecholamines
Concept Cations
Concept Chlorpromazine
Concept Cholera Toxin
Concept Clozapine
Concept Dimethylphenylpiperazinium Iodide
Concept Dose-Response Relationship, Drug
Concept Drug Interactions
Concept Drug Synergism
Concept Estradiol
Concept Estrenes
Concept Fibroblast Growth Factors
Concept Colforsin
Concept Ion Channels
Concept Ionophores
Concept Ions
Concept Isoenzymes
Concept Lidocaine
Concept Manganese
Concept Melatonin
Concept Membrane Proteins
Concept Muscle Proteins
Concept Neomycin
Concept Nerve Tissue Proteins
Concept Neurotensin
Concept Nicotine
Concept Nifedipine
Concept Norepinephrine
Concept Nuclear Proteins
Concept Parasympathomimetics
Concept Peptide Fragments
Concept Peptides
Concept Phenethylamines
Concept Phosphodiesterase Inhibitors
Concept Type C Phospholipases
Concept Plant Extracts
Concept Potassium
Concept Protamines
Concept Protein Kinase C
Concept Proteins
Concept Pyrazoles
Concept Pyrrolidinones
Concept Quinolines
Concept Receptors, Adrenergic, beta
Concept Receptors, Cholinergic
Concept Receptors, Cell Surface
Concept Receptors, Nicotinic
Concept Recombinant Fusion Proteins
Concept RNA, Messenger
Concept Serine Endopeptidases
Concept Sodium
Concept Solvents
Concept Sympathomimetics
Concept Tetradecanoylphorbol Acetate
Concept Thionucleotides
Concept Tritium
Concept Tryptamines
Concept Tyrosine
Concept Uridine Triphosphate
Concept Verapamil
Concept Veratridine
Concept Water
Concept Calcium Channels
Concept Sodium Channels
Concept Inositol 1,4,5-Trisphosphate
Concept Oncogene Protein p21(ras)
Concept Ionomycin
Concept Cell Adhesion Molecules
Concept Cell Adhesion Molecules, Neuronal
Concept Fibroblast Growth Factor 2
Concept Extracellular Matrix Proteins
Concept Oncogene Proteins v-fos
Concept Interferon-alpha
Concept Cyclic AMP-Dependent Protein Kinases
Concept Receptors, Bradykinin
Concept Receptors, Neurotensin
Concept Receptors, Purinergic P1
Concept Receptors, Purinergic P2
Concept Agrin
Concept Dopamine Antagonists
Concept Interleukin-12
Concept Nicotinic Agonists
Concept Nicotinic Antagonists
Concept GABA Antagonists
Concept Antigens, CD34
Concept Phosphotyrosine
Concept GTP-Binding Proteins
Concept Thapsigargin
Concept Phosphatidylinositol 3-Kinases
Concept Protein Isoforms
Concept Caspases
Concept Enzyme Activators
Concept Calcium Channels, L-Type
Concept Receptor Protein-Tyrosine Kinases
Concept rac1 GTP-Binding Protein
Concept Calcium Channels, N-Type
Concept omega-Conotoxin GVIA
Concept Mitogen-Activated Protein Kinase Kinases
Concept Tumor Suppressor Proteins
Concept Ubiquitin
Concept Sodium Channel Blockers
Concept Adaptor Proteins, Vesicular Transport
Concept Receptor, Bradykinin B2
Concept Ubiquitin-Protein Ligases
Concept Cytochromes c
Concept Multiprotein Complexes
Concept Depsipeptides
Concept Adaptor Proteins, Signal Transducing
Concept Green Fluorescent Proteins
Concept Crk-Associated Substrate Protein
Concept Oncogene Protein v-crk
Concept Proto-Oncogene Proteins c-crk
Concept STAT1 Transcription Factor
Concept STAT4 Transcription Factor
Concept Apoptosis Regulatory Proteins
Concept BH3 Interacting Domain Death Agonist Protein
Concept Proto-Oncogene Proteins c-akt
Concept GRB2 Adaptor Protein
Concept Focal Adhesion Protein-Tyrosine Kinases
Concept Protein Tyrosine Phosphatase, Non-Receptor Type 11
Concept Phospholipase C beta
Concept Phospholipase C delta
Concept NK Cell Lectin-Like Receptor Subfamily A
Concept Receptors, Purinergic P2X2
Concept Purinergic Agonists
Concept Calbindins
Academic Article Inhibition of nicotinic receptor-mediated catecholamine secretion by Dryobalanops aromatica in bovine adrenal chromaffin cells.
Academic Article Noncompetitive inhibition by camphor of nicotinic acetylcholine receptors.
Academic Article Inhibition of nicotinic acetylcholine receptors and calcium channels by clozapine in bovine adrenal chromaffin cells.
Academic Article Inhibition of acetylcholine-mediated effects by borneol.
Academic Article Activation of B2 bradykinin receptors by neurotensin.
Academic Article Synergistic activation of adenylyl cyclase is dependent upon phospholipase C-mediated processes in human neuroblastoma SK-N-BE(2)C cells.
Grant "Development of CT10 regulator of kinase (Crk) and Crk-like (CrkL) inhibitors for glioblastoma treatment"
Academic Article Requirement for Crk and CrkL during postnatal lens development.
Grant "Advanced development of Crk and CrkL inhibitors for glioblastoma treatment (renewal)"
Grant "Inhibition of glioblastoma invasion using CRK/CRKL-antagonist peptides"

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