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Park, Taeju

One or more keywords matched the following properties of Park, Taeju

Property	Value
keywords	Breast Cancer
keywords	Cancer Cell Migration
keywords	Cancer Cell Invasion
research overview	Dr. Park’s study is focused on two proteins – Crk and CrkL – that are reported to be elevated in several types of human cancer including glioblastoma (GBM) and correlated with poor prognosis. Tumor cell migration and invasion contribute to the spread of GBM to healthy brain tissues, leading to high recurrence rates. Dr. Park has demonstrated that Crk and CrkL play important roles in GBM cell migration and invasion. Dr. Park is also working on potential role of Crk and CrkL in diffuse intrinsic pontine glioma (DIPG) cell migration and invasion. In addition, Dr. Park is working to develop specific inhibitors of these proteins to block GBM and DIPG cell migration and invasion. In the lab, Dr. Park and his team take advantage of genetically engineered mouse models and the gene knockdown and overexpression technique to study tumorigenic functions of Crk and CrkL. They identified a protein that is activated by elevation of Crk and CrkL and binds to Crk and CrkL. The new malignant connection promotes tumor cell migration and invasion. Dr. Park’s goal is to develop drugs that specifically break down the aberrant protein-protein complex between Crk and CrkL and their binding partners. To test effects of chemical compounds on the binding of these proteins, Dr. Park developed in vitro assay systems and conducted a high-throughput screen. In partnership with the University of Kansas Cancer Center, the team has tested 200,000 chemical compounds and identified more than 600 potential candidate drugs. These compounds are undergoing rigorous post-screening validation using different biochemical experiments. They will continue to expand productive collaboration with KU core facilities to discover novel anticancer drugs. They are optimizing a new quadruple screening to discover inhibitors of both SH2 and SH3 domains of Crk and CrkL. The newly developed inhibitors will be used to advance studies of cancer and other human diseases in which Crk and CrkL play essential roles. Previously, Dr. Park generated mutant mice lacking both Crk and CrkL in the developing brain and demonstrated that Crk and CrkL play essential overlapping functions in neuronal migration during brain development. Recently, genomic analysis of a patient with a severe global developmental delay and ataxia identified two new mutations in Crk and another protein that may interact with Crk. His team generated two mutant mouse strains harboring the two mutations and plan to study individual and combined contributions of the two genes to brain development. These phenotyping results will provide essential knowledge for understanding both the underlying mechanism of the clinical deficits and the signaling pathways in brain development, therefore laying the foundation for developing therapeutic interventions.

One or more keywords matched the following items that are connected to Park, Taeju

Item Type	Name
Concept	Cell Adhesion
Concept	Cell Differentiation
Concept	Cell Line
Concept	Cell Line, Transformed
Concept	Cell Membrane
Concept	Cell Movement
Concept	Cell Transformation, Neoplastic
Concept	Cells, Cultured
Concept	Killer Cells, Natural
Concept	Neoplasms
Concept	Purkinje Cells
Concept	Receptors, Cell Surface
Concept	Tumor Cells, Cultured
Concept	Cell Adhesion Molecules
Concept	Cell Adhesion Molecules, Neuronal
Concept	PC12 Cells
Concept	Cell Polarity
Concept	HL-60 Cells
Concept	Jurkat Cells
Concept	Chromaffin Cells
Concept	COS Cells
Concept	Cell Line, Tumor
Concept	Cell Shape
Concept	Cell Proliferation
Concept	NK Cell Lectin-Like Receptor Subfamily A
Concept	HEK293 Cells
Academic Article	Crk proteins transduce FGF signaling to promote lens fiber cell elongation.
Academic Article	CRK proteins selectively regulate T cell migration into inflamed tissues.
Academic Article	Crk and CrkL are required for cell transformation by v-fos and v-ras.
Academic Article	Neurobiology: Reelin mediates form and function.
Academic Article	Dendritic planarity of Purkinje cells is independent of Reelin signaling.
Academic Article	Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis.
Academic Article	Essential roles of Crk and CrkL in fibroblast structure and motility.
Academic Article	Neomycin inhibits catecholamine secretion by blocking nicotinic acetylcholine receptors in bovine adrenal chromaffin cells.
Academic Article	Temperature sensitivity of catecholamine secretion and ion fluxes in bovine adrenal chromaffin cells.
Academic Article	Characterization of high affinity neurotensin receptor NTR1 in HL-60 cells and its down regulation during granulocytic differentiation.
Academic Article	Phospholipase C-delta1 is activated by capacitative calcium entry that follows phospholipase C-beta activation upon bradykinin stimulation.
Academic Article	Chlorpromazine-induced inhibition of catecholamine secretion by a differential blockade of nicotinic receptors and L-type Ca2+ channels in rat pheochromocytoma cells.
Academic Article	Nongenomic inhibition of catecholamine secretion by 17beta-estradiol in PC12 cells.
Academic Article	Inhibition of nicotinic receptor-mediated catecholamine secretion by Dryobalanops aromatica in bovine adrenal chromaffin cells.
Academic Article	Noncompetitive inhibition by camphor of nicotinic acetylcholine receptors.
Academic Article	Inhibition of nicotinic acetylcholine receptors and calcium channels by clozapine in bovine adrenal chromaffin cells.
Academic Article	Coupling of L-type voltage-sensitive calcium channels to P2X(2) purinoceptors in PC-12 cells.
Academic Article	Inhibition of acetylcholine-mediated effects by borneol.
Academic Article	Activation of B2 bradykinin receptors by neurotensin.
Academic Article	Inhibition of ubiquitin ligase Siah-1A by disabled-1.
Academic Article	Protein kinase C regulates the activity and stability of serotonin N-acetyltransferase.
Academic Article	Cardiovascular and craniofacial defects in Crk-null mice.
Academic Article	Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway.
Academic Article	Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L.
Academic Article	The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress.
Academic Article	Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease.
Academic Article	Cyclic AMP-independent inhibition of voltage-sensitive calcium channels by forskolin in PC12 cells.
Academic Article	Synergistic activation of adenylyl cyclase is dependent upon phospholipase C-mediated processes in human neuroblastoma SK-N-BE(2)C cells.
Academic Article	A2A adenosine receptors inhibit ATP-induced Ca2+ influx in PC12 cells by involving protein kinase A.
Academic Article	Differential inhibition of catecholamine secretion by amitriptyline through blockage of nicotinic receptors, sodium channels, and calcium channels in bovine adrenal chromaffin cells.
Academic Article	Inhibition of voltage-sensitive calcium channels by the A2A adenosine receptor in PC12 cells.
Academic Article	Crk Adaptor Proteins Regulate NK Cell Expansion and Differentiation during Mouse Cytomegalovirus Infection.
Grant	"Development of CT10 regulator of kinase (Crk) and Crk-like (CrkL) inhibitors for glioblastoma treatment"
Grant	"Requirement of the Crk/CrkL/p130Cas in cancer cell migration and invasion"
Grant	"Requirement of CT10 regulator of kinase (Crk) and Crk-like (CrkL) in glioblastoma growth"
Academic Article	Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion.
Grant	"Advanced development of Crk and CrkL inhibitors for glioblastoma treatment (renewal)"
Grant	"Role of Crk and CrkL in diffuse intrinsic potine glioma (DIPG) cell migration and invasion"
Academic Article	Quantitative assessment of glioblastoma phenotypes in?vitro establishes cell migration as a robust readout of Crk and CrkL activity.
Academic Article	Crk and CrkL as Therapeutic Targets for Cancer Treatment.
Academic Article	Crk and Crkl have shared functions in neural crest cells for cardiac outflow tract septation and vascular smooth muscle differentiation.
Academic Article	Real-time quantitative measurement of tumor cell migration and invasion following synthetic mRNA transfection
Academic Article	Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection.

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Cancer
Cell
Invasion