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research overview In his former role as Director of the Division of Clinical Pharmacology and Therapeutic Innovation at Children’s Mercy Dr. Leeder led a program consisting of multidisciplinary teams of researchers with expertise in analytical chemistry, drug biotransformation, gene regulation, pharmacogenomics, and pharmacokinetics to investigate variability in medication response in children. An important component of the program was to provide an environment in which trainees and early career faculty members from diverse backgrounds could develop as independent investigators in their areas of research interest. These research interests generally are closely aligned with their clinical expertise with the goal of implementing precision therapeutics in their clinical subspecialties to benefit the patients they serve. Currently, Dr Leeder leads the Children’s Mercy Research Institute's Precision Therapeutics Area of Emphasis, which extends the Division of Clinical Pharmacology's emphasis on developing individuals to a more institutional level by providing support to pediatric subspecialties interested in adding precision therapeutics to their portfolio of research programs. In this way the program serves as a model of integrated research that will extend throughout the CMRI. Dr. Leeder’s research focuses on characterizing the relative contributions of ontogeny, genetic variation and disease to observed variability in drug disposition and response in children. Over the years, these research activities have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids with current funding as one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development.

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item TypeName
Concept Ambulatory Care Facilities
Concept Intensive Care Units, Neonatal
Concept Intensive Care Units, Pediatric
Concept Health Care Costs
Concept Delivery of Health Care, Integrated
Academic Article Pharmacogenetics and pharmacogenomics.
Academic Article Personalized medicine: reality and reality checks.
Academic Article Platform dependence of inference on gene-wise and gene-set involvement in human lung development.
Academic Article Transcriptomic analysis of human lung development.
Academic Article A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma.
Academic Article Expression analysis of asthma candidate genes during human and murine lung development.
Academic Article Fetal lung and placental methylation is associated with in utero nicotine exposure.
Academic Article Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome.
Academic Article Design and Testing of an EHR-Integrated, Busulfan Pharmacokinetic Decision Support Tool for the Point-of-Care Clinician.
Academic Article Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future.
Academic Article Cost and Potential Avoidability of Antibiotic-Associated Adverse Drug Reactions in Children.
Academic Article Intensive and prolonged urine collection in preterm infants reveals three distinct indomethacin metabolic patterns: potential implications for drug dosing.
Academic Article Newborn Sequencing in Genomic Medicine and Public Health.
Academic Article Pediatric Pharmacovigilance: Enhancing Adverse Drug Reaction Reporting in a Tertiary Care Children's Hospital.
Academic Article Pharmacogenomics and implementation of precision therapeutics in the neonatal ICU: a new frontier?
Grant 2019 Drug Metabolism Gordon Research Conference Guiding Drug Development Using Translational ADME Science
Grant Ontogeny and Genetics of NSAID Dose-Exposure Relationship in Preterm Infants
Grant Clinical and Translational Mentored Career Development Award
Grant Frontiers Clinical and Translational Science Institute at the University of Kansas
Grant Effect of Obesity on Pantoprazole Pharmacokinetics and Pharmacodynamics in Children

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