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Leeder, J. Steven

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item Type	Name
Concept	Acute-Phase Proteins
Concept	Carrier Proteins
Concept	Drug Interactions
Concept	Heat-Shock Proteins
Concept	Microfilament Proteins
Concept	Neoplasm Proteins
Concept	Protein Binding
Concept	Protein Conformation
Concept	Protein-Tyrosine Kinases
Concept	Proteins
Concept	Proto-Oncogene Proteins
Concept	Recombinant Proteins
Concept	Protein Disulfide-Isomerases
Concept	Protein Isoforms
Concept	Tacrolimus Binding Proteins
Concept	Mitochondrial Proteins
Concept	Membrane Transport Proteins
Concept	Multidrug Resistance-Associated Proteins
Concept	Soybean Proteins
Concept	Databases, Protein
Concept	Serotonin Plasma Membrane Transport Proteins
Concept	Wnt Proteins
Concept	CCAAT-Enhancer-Binding Protein-delta
Academic Article	Interactions between N-acetyl-p-benzoquinone imine and fluorescent calcium probes: implications for mechanistic toxicology.
Academic Article	Information theory-based analysis of CYP2C19, CYP2D6 and CYP3A5 splicing mutations.
Academic Article	Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro.
Academic Article	Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: insights into PXR-mediated gene regulation.
Academic Article	CYP2D7 splice variants in human liver and brain: does CYP2D7 encode functional protein?
Academic Article	Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.
Academic Article	Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail.
Academic Article	Biotransformation of fluticasone: in vitro characterization.
Academic Article	CYP3A4-Mediated carbamazepine (CBZ) metabolism: formation of a covalent CBZ-CYP3A4 adduct and alteration of the enzyme kinetic profile.
Academic Article	A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma.
Academic Article	NTP-CERHR expert panel report on the developmental toxicity of soy infant formula.
Academic Article	Red blood cell folate concentrations and polyglutamate distribution in juvenile arthritis: predictors of folate variability.
Academic Article	Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)
Academic Article	Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor.
Academic Article	Risk score modeling of multiple gene to gene interactions using aggregated-multifactor dimensionality reduction.
Academic Article	Epitope mapping studies with human anti-cytochrome P450 3A antibodies.
Academic Article	Age related changes in fractional elimination pathways for drugs: assessing the impact of variable ontogeny on metabolic drug-drug interactions.
Academic Article	Pharmacogenetics in pediatrics. Implications for practice.
Academic Article	Drug metabolism for the paediatrician.
Academic Article	Reference intervals for urinary renal injury biomarkers KIM-1 and NGAL in healthy children.
Academic Article	Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters.
Academic Article	Glucocorticoid genes and the developmental origins of asthma susceptibility and treatment response.
Academic Article	Patients with delayed-onset sulfonamide hypersensitivity reactions have antibodies recognizing endoplasmic reticulum luminal proteins.
Academic Article	CYP3A isoforms in Ewing's sarcoma tumours: an immunohistochemical study with clinical correlation.
Academic Article	Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Academic Article	Decreased Pregnane X Receptor Expression in Children with Active Crohn's Disease.
Academic Article	Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics.
Academic Article	Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development.
Academic Article	Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes.
Academic Article	Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver.
Academic Article	Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.
Academic Article	Age- and Genotype-Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate-Glucuronosyltransferases in Human Liver.
Academic Article	Cytochrome P450 3A: ontogeny and drug disposition.
Academic Article	Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".
Academic Article	Aprepitant and fosaprepitant drug interactions: a systematic review.
Academic Article	Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.
Academic Article	Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants.
Academic Article	Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.
Academic Article	Optimized Renal Transporter Quantification by Using Aquaporin 1 and Aquaporin 2 as Anatomical Markers: Application in Characterizing the Ontogeny of Renal Transporters and Its Correlation with Hepatic Transporters in Paired Human Samples.
Academic Article	In: Metabolic Drug Interactions, Levy RH, Thummel KE, Trager WF, Hansten PD and Eichelbaum M, eds
Academic Article	In: Antiepileptic Drugs, 5th Edition, Levy RH et al, (Eds.)
Grant	2019 Drug Metabolism Gordon Research Conference Guiding Drug Development Using Translational ADME Science
Grant	Trimethoprim: an overlooked contributor of trimethoprim-sulfamethoxazole idiosyncratic adverse drug reactions
Academic Article	Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver.
Academic Article	The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites.
Academic Article	Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver.
Academic Article	Interindividual Variability and Differential Tissue Abundance of Mitochondrial Amidoxime Reducing Component Enzymes in Humans.
Academic Article	Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective.
Grant	Ontogeny of drug transport
Grant	Effect of Obesity on Pantoprazole Pharmacokinetics and Pharmacodynamics in Children
Academic Article	Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants.
Academic Article	Impact of CYP2C:TG Haplotype on CYP2C19 Substrates Clearance In Vivo, Protein Content, and In Vitro Activity.
Academic Article	Ontogeny of Scaling Factors for Pediatric Physiologically Based Pharmacokinetic Modeling and Simulation: Cytosolic Protein Per Gram of Liver.

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