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keywords Pediatric Clinical Pharmacology
keywords Developmental Pharmacogenomics
keywords Pediatric Pharmacogenetics
keywords Pediatric Precision Therapeutics
research overview In his former role as Director of the Division of Clinical Pharmacology and Therapeutic Innovation at Children’s Mercy Dr. Leeder led a program consisting of multidisciplinary teams of researchers with expertise in analytical chemistry, drug biotransformation, gene regulation, pharmacogenomics, and pharmacokinetics to investigate variability in medication response in children. An important component of the program was to provide an environment in which trainees and early career faculty members from diverse backgrounds could develop as independent investigators in their areas of research interest. These research interests generally are closely aligned with their clinical expertise with the goal of implementing precision therapeutics in their clinical subspecialties to benefit the patients they serve. Currently, Dr Leeder leads the Children’s Mercy Research Institute's Precision Therapeutics Area of Emphasis, which extends the Division of Clinical Pharmacology's emphasis on developing individuals to a more institutional level by providing support to pediatric subspecialties interested in adding precision therapeutics to their portfolio of research programs. In this way the program serves as a model of integrated research that will extend throughout the CMRI. Dr. Leeder’s research focuses on characterizing the relative contributions of ontogeny, genetic variation and disease to observed variability in drug disposition and response in children. Over the years, these research activities have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids with current funding as one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development.

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item TypeName
Concept Hospitals, Pediatric
Concept Pediatrics
Concept Pharmacogenetics
Concept Intensive Care Units, Pediatric
Concept Pediatric Obesity
Academic Article Pharmacogenetics and pharmacogenomics.
Academic Article The challenges of delivering pharmacogenomics into clinical pediatrics.
Academic Article Cytochrome P450 pharmacogenetics and anaesthesia.
Academic Article Information theory-based analysis of CYP2C19, CYP2D6 and CYP3A5 splicing mutations.
Academic Article Developmental and pediatric pharmacogenomics.
Academic Article Developmental pharmacology--drug disposition, action, and therapy in infants and children.
Academic Article Translating pharmacogenetics and pharmacogenomics into drug development for clinical pediatrics and beyond.
Academic Article Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans.
Academic Article Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.
Academic Article Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother.
Academic Article Application of pharmacogenomic strategies to the study of drug-induced birth defects.
Academic Article The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype.
Academic Article Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects.
Academic Article Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study.
Academic Article Personalized medicine: reality and reality checks.
Academic Article Developmental pharmacogenetics: a general paradigm for application to neonatal pharmacology and toxicology.
Academic Article CYP2D7-2D6 hybrid tandems: identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction.
Academic Article Understanding the relative roles of pharmacogenetics and ontogeny in pediatric drug development and regulatory science.
Academic Article Developmental pharmacogenetics in pediatric rheumatology: utilizing a new paradigm to effectively treat patients with juvenile idiopathic arthritis with methotrexate.
Academic Article Identifying genomic and developmental causes of adverse drug reactions in children.
Academic Article Conference scene: pediatric pharmacogenomics and personalized medicine.
Academic Article PharmGKB summary: carbamazepine pathway.
Academic Article Development of biomarkers to optimize pediatric patient management: what makes children different?
Academic Article CYP2D6, SULT1A1 and UGT2B17 copy number variation: quantitative detection by multiplex PCR.
Academic Article PharmGKB summary: phenytoin pathway.
Academic Article Interpreting pharmacogenetic data in the developing neonate: the challenge of hitting a moving target.
Academic Article Pediatric pharmacogenomics: a systematic assessment of ontogeny and genetic variation to guide the design of statin studies in children.
Academic Article Trends in adverse reactions to trimethoprim-sulfamethoxazole.
Academic Article Fluticasone propionate pharmacogenetics: CYP3A4*22 polymorphism and pediatric asthma control.
Academic Article Valproic acid pathway: pharmacokinetics and pharmacodynamics.
Academic Article High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6.
Academic Article Pharmacogenetics in pediatrics. Implications for practice.
Academic Article Drug metabolism for the paediatrician.
Academic Article Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.
Academic Article Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy.
Academic Article CYP2D6 and pharmacogenomics: where does future research need to focus? Part 1: technical aspects.
Academic Article Effect of CYP3A5 genotype, steroids, and azoles on tacrolimus in a pediatric renal transplant population.
Academic Article Individualizing the use of medications in children: making Goldilocks happy.
Academic Article CYP2D6 and pharmacogenomics: where does future research need to focus? Part 2: clinical aspects.
Academic Article Detection of an endogenous urinary biomarker associated with CYP2D6 activity using global metabolomics.
Academic Article Meaningful use and clinical utility of preemptive pharmacogenetic testing: (re)view from a CYP2D6 poor metabolizer.
Academic Article Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing.
Academic Article Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors.
Academic Article Genetic determinants of fetal opiate exposure and risk of neonatal abstinence syndrome: Knowledge deficits and prospects for future research.
Academic Article Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Academic Article Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.
Academic Article Quantification of pravastatin acid, lactone and isomers in human plasma by UHPLC-MS/MS and its application to a pediatric pharmacokinetic study.
Academic Article Non-monooxygenase cytochromes P450 as potential human autoantigens in anticonvulsant hypersensitivity reactions.
Academic Article Prediction of CYP2D6 phenotype from genotype across world populations.
Academic Article NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations.
Academic Article Quantification of intraindividual variability and the influence of menstrual cycle phase on CYP2D6 activity as measured by dextromethorphan phenotyping.
Academic Article Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy.
Academic Article The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database.
Academic Article Cost and Potential Avoidability of Antibiotic-Associated Adverse Drug Reactions in Children.
Academic Article Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.
Academic Article Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects.
Academic Article Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.
Academic Article PharmGKB summary: clobazam pathway, pharmacokinetics.
Academic Article Glucuronidation in humans. Pharmacogenetic and developmental aspects.
Academic Article Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data.
Academic Article Limitations of dextromethorphan N-demethylation as a measure of CYP3A activity.
Academic Article Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.
Academic Article Newborn Sequencing in Genomic Medicine and Public Health.
Academic Article Pediatric Pharmacovigilance: Enhancing Adverse Drug Reaction Reporting in a Tertiary Care Children's Hospital.
Academic Article Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity.
Academic Article Pharmacogenomics and implementation of precision therapeutics in the neonatal ICU: a new frontier?
Academic Article Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.
Academic Article Considerations for Implementing Precision Therapeutics for Children.
Academic Article Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia.
Academic Article Adverse drug reaction active surveillance: developing a national network in Canada's children's hospitals.
Academic Article Examining the role of precision medicine with oral baclofen in pediatric patients with cerebral palsy
Academic Article In: Problems in Pediatric Drug Therapy, Fourth Edition, Pagliaro LA and Pagliaro AM (Eds)
Academic Article In: Neonatal and Pediatric Pharmacology, Third Edition, Yaffe S and Aranda J, (Eds)
Academic Article In: Nelson Textbook of Pediatrics, 18th Edition, Kliegman, Behrman, Jenson and Stanton, (Eds)
Academic Article In: Neonatal and Pediatric Pharmacology, Fourth Edition, Yaffe S and Aranda J, (Eds
Academic Article In: Nelson Textbook of Pediatrics, 19th Edition, Kliegman RM, Stanton BF, St. Geme III JW, Schor NF, Behrman RE, (Eds)
Academic Article Principles of Drug Administration in Children Receiving Renal Replacement Therapy Second Edition
Academic Article In Biochemical and Molecular Basis of Pediatric Disease, 4th Ed., Wong E, Bennett M, and Dietzen D, eds
Academic Article In: Principles of Pharmacogenetics and Pharmacogenomics, Altman RB, Flockhart D, and Goldstein DB, (Eds),
Academic Article In: Nelson Textbook of Pediatrics, 20th Edition, Kliegman RM, Stanton BF, St. Geme III JW, Schor NF, (Eds)
Academic Article In: Textbook of Pediatric Rheumatology, Seventh Edition, Petty RE, Laxer RM, Lindsley CB, Wedderburn LR, (Eds)
Grant Ontogeny and Genetics of NSAID Dose-Exposure Relationship in Preterm Infants
Academic Article Examining the role of precision medicine with oral baclofen in pediatric patients with cerebral palsy.
Academic Article A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy.
Academic Article Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver.
Academic Article Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia.
Award or Honor Receipt Sumner J. Yaffe Lifetime Achievement Award in Pediatric Pharmacology and Therapeutics
Academic Article Ontogeny Related Changes in the Pediatric Liver Metabolome.
Academic Article Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy.
Academic Article Analysis Approaches to Identify Pharmacogenetic Associations With Pharmacodynamics.
Academic Article Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver.
Academic Article Ontogeny of Pediatric Pharmacogenetics: Celebrating the Past and Vision for the Future.
Academic Article Pediatric growth patterns in youth-onset type 2 diabetes mellitus: Implications for physiologically-based pharmacokinetic models.
Academic Article Genomic answers for children: Dynamic analyses of >1000 pediatric rare disease genomes.
Grant Ontogeny of drug transport
Grant Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids
Grant Children’s Mercy Hospital Collaborative Fellowship Program in Pediatric Pharmacology
Grant Effect of Obesity on Pantoprazole Pharmacokinetics and Pharmacodynamics in Children

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  • Pediatric
  • Pharmacogenetics