Loading...
Keywords
Last Name
Institution

Connection

Search Results to J. Steven Leeder

This is a "connection" page, showing the details of why an item matched the keywords from your search.

                     
                     

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item TypeName
Concept Liver
Concept Microsomes, Liver
Academic Article Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
Academic Article Cytochrome P450 pharmacogenetics and anaesthesia.
Academic Article Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro.
Academic Article Ontogeny of drug metabolizing enzymes in the neonate.
Academic Article Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans.
Academic Article Variability of CYP3A7 expression in human fetal liver.
Academic Article Pathways of carbamazepine bioactivation in vitro: II. The role of human cytochrome P450 enzymes in the formation of 2-hydroxyiminostilbene.
Academic Article CYP2D7 splice variants in human liver and brain: does CYP2D7 encode functional protein?
Academic Article Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.
Academic Article Human anti-cytochrome P450 antibodies in aromatic anticonvulsant-induced hypersensitivity reactions.
Academic Article Biotransformation of fluticasone: in vitro characterization.
Academic Article Variability of CYP2J2 expression in human fetal tissues.
Academic Article Expression and inducibility of antigens in severe combined immunodeficient mice recognized by human anti-P450 antibodies.
Academic Article Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects.
Academic Article Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
Academic Article Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.
Academic Article Betaine-homocysteine methyltransferase: human liver genotype-phenotype correlation.
Academic Article Developmental variations in metabolic capacity of flavin-containing mono-oxygenase 3 in childhood.
Academic Article The role of CYP3A4 mRNA transcript with shortened 3'-untranslated region in hepatocyte differentiation, liver development, and response to drug induction.
Academic Article Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)
Academic Article Cotinine in human placenta predicts induction of gene expression in fetal tissues.
Academic Article Age related changes in fractional elimination pathways for drugs: assessing the impact of variable ontogeny on metabolic drug-drug interactions.
Academic Article High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6.
Academic Article Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity.
Academic Article Urinary biomarkers of trimethoprim bioactivation in vivo following therapeutic dosing in children.
Academic Article Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters.
Academic Article Acetaminophen overdose with therapeutic intent.
Academic Article Variability in Expression of CYP3A5 in Human Fetal Liver.
Academic Article In Vitro Hepatic Oxidative Biotransformation of Trimethoprim.
Academic Article Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Academic Article Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.
Academic Article Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.
Academic Article Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics.
Academic Article Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes.
Academic Article Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants.
Academic Article Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs.
Academic Article Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase.
Academic Article Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver.
Academic Article Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.
Academic Article Potent inhibition of cytochrome P-450 2D6-mediated dextromethorphan O-demethylation by terbinafine.
Academic Article Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.
Academic Article Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.
Academic Article Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.
Academic Article Novel Protective Role of Nicotinamide Phosphoribosyltransferase in Acetaminophen-Induced Acute Liver Injury in Mice.
Academic Article Age- and Genotype-Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate-Glucuronosyltransferases in Human Liver.
Academic Article Cellular toxicity of sulfamethoxazole reactive metabolites--II. Inhibition of natural killer activity in human peripheral blood mononuclear cells.
Academic Article Acetaminophen intoxication during treatment: what you don't know can hurt you.
Academic Article Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants.
Academic Article Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia.
Academic Article Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.
Academic Article A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents.
Academic Article Optimized Renal Transporter Quantification by Using Aquaporin 1 and Aquaporin 2 as Anatomical Markers: Application in Characterizing the Ontogeny of Renal Transporters and Its Correlation with Hepatic Transporters in Paired Human Samples.
Academic Article In: Handbook of Experimental Pharmacology Volume 121: Drug-Induced Hepatotoxicity. Cameron RG, Feuer G and de la Iglesia F, Eds
Academic Article In: Drug-Induced Liver Toxicity, 2nd Edition, Kaplowitz N and DeLeve L (Eds.)
Academic Article In: Drug-Induced Liver Toxicity, 3rd Edition, Kaplowitz N and DeLeve L (Eds.)
Grant 2019 Drug Metabolism Gordon Research Conference Guiding Drug Development Using Translational ADME Science
Grant PBPK prediction of ontogeny mediated alteration in hepatic drug elimination
Grant Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids
Academic Article Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver.
Academic Article Ontogeny Related Changes in the Pediatric Liver Metabolome.

Search Criteria
  • Liver