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Search Results to Andrea Gaedigk

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research overview Dr. Gaedigk's research interests focus on genes involved in drug metabolism, transport and response and how genetic variation can explain the wide ranges of variability that are observed for protein function among individuals. Since many drugs are metabolized by Cytochrome P450 enzymes, much of her work has revolved around CYP enzymes, in particular CYP2D6. During her career, she has characterized the CYP2D6 gene locus in many ethnically different populations, discovered numerous allelic variants and developed methods that reliably identify variant alleles. Dr Gaedigk is the Director of the Pharmacogene Variation Consortium (PharmVar), which provides PGx gene nomenclature by serving as a centralized “next Generation’ pharmacogene data repository. In this capacity, she is also closely working with the Pharmacogenomic Knowledgebase (PharmGKB), a globally renown pharmacogenetics resource. Furthermore, her pharmacogenomic expertise is also recognized by her leadership role on several Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines. Lastly, Dr. Gaedigk is also part of the GOLDILOKs initiative (Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids) that seeks to better understand atomoxetine treatment for ADHD and develop clinical decision tools to optimize PGx-guided drug therapy.

One or more keywords matched the following items that are connected to Gaedigk, Andrea

Item TypeName
Concept Administration, Oral
Concept Blood Specimen Collection
Concept Breath Tests
Concept Chromatography, High Pressure Liquid
Concept Chromatography, Liquid
Concept Chromosome Mapping
Concept Clinical Trials as Topic
Concept Cloning, Molecular
Concept Cross-Sectional Studies
Concept Delphi Technique
Concept DNA Mutational Analysis
Concept Double-Blind Method
Concept Drug Labeling
Concept Electrophoresis, Polyacrylamide Gel
Concept Evaluation Studies as Topic
Concept Feasibility Studies
Concept Follow-Up Studies
Concept Genetic Testing
Concept Histocytochemistry
Concept Hospitalization
Concept Mixed Function Oxygenases
Concept Immunohistochemistry
Concept Infusions, Intravenous
Concept Longitudinal Studies
Concept Marketing of Health Services
Concept Gas Chromatography-Mass Spectrometry
Concept Metabolic Clearance Rate
Concept Pilot Projects
Concept Population Surveillance
Concept Prognosis
Concept Prospective Studies
Concept Psychometrics
Concept Radiotherapy
Concept Random Allocation
Concept Reference Standards
Concept Research
Concept Research Design
Concept Tonsillectomy
Concept Transfection
Concept Blotting, Western
Concept Restriction Mapping
Concept Cohort Studies
Concept Substance Abuse Detection
Concept Logistic Models
Concept Case-Control Studies
Concept Kidney Transplantation
Concept Polymerase Chain Reaction
Concept Mutagenesis, Site-Directed
Concept Sequence Alignment
Concept Electrophoresis, Gel, Pulsed-Field
Concept Mycological Typing Techniques
Concept Drug Monitoring
Concept In Situ Hybridization
Concept Sequence Analysis, DNA
Concept Crystallography, X-Ray
Concept Risk Assessment
Concept Cross-Over Studies
Concept Epitope Mapping
Concept Reverse Transcriptase Polymerase Chain Reaction
Concept Oligonucleotide Array Sequence Analysis
Concept Gene Expression Profiling
Concept Microfluidic Analytical Techniques
Concept Tandem Mass Spectrometry
Concept Medication Therapy Management
Concept Drug Dosage Calculations
Concept Genome-Wide Association Study
Concept Genetic Association Studies
Concept Precision Medicine
Concept High-Throughput Nucleotide Sequencing
Concept Genotyping Techniques
Concept Multiplex Polymerase Chain Reaction
Concept Real-Time Polymerase Chain Reaction
Concept In Vitro Techniques
Academic Article Effect of sex and menstrual cycle phase on cytochrome P450 2C19 activity with omeprazole used as a biomarker.
Academic Article Omeprazole disposition in children following single-dose administration.
Academic Article Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".
Academic Article Lack of weight-based dose dependency and intraindividual variability of omeprazole for CYP2C19 phenotyping.
Academic Article Maribavir pharmacokinetics and the effects of multiple-dose maribavir on cytochrome P450 (CYP) 1A2, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A, N-acetyltransferase-2, and xanthine oxidase activities in healthy adults.
Academic Article Genetic determinants of variable metabolism have little impact on the clinical use of leading antipsychotics in the CATIE study.
Academic Article Epitope mapping studies with human anti-cytochrome P450 3A antibodies.
Academic Article Identification of the primary gene defect at the cytochrome P450 CYP2D locus.
Academic Article Interethnic differences of drug-metabolizing enzymes.
Academic Article Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".

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