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Search Results to Alain C. Cuna

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research overview Dr. Cuna's main research interest is on defining the pathogenesis of necrotizing enterocolitis (NEC) – a devastating inflammatory bowel disease of preterm infants - and translating this knowledge to improve outcomes of NEC. His current focus is on understanding how host genetics and intestinal bacterial communities interact with each other to modulate inflammation in the developing neonatal gut. New knowledge gained from this research is anticipated to help in the development of personalized, microbial-based therapies based on underlying genetic predisposition and/or gut microbiome signatures to help maintain gut homeostasis. Such novel, individualized therapies are expected to drastically reduce the incidence of NEC in a safe and effective manner by targeting infants at highest risk of the disease.

One or more keywords matched the following items that are connected to Cuna, Alain

Item TypeName
Concept Adrenal Cortex Hormones
Concept Animals, Newborn
Concept Anti-Inflammatory Agents
Concept Child Development
Concept Dexamethasone
Concept DNA
Concept Drug Administration Schedule
Concept Glucocorticoids
Concept Infant, Newborn
Concept Infant, Newborn, Diseases
Concept Language Development
Concept Language Development Disorders
Concept Lipopolysaccharides
Concept Prednisolone
Concept Respiratory Distress Syndrome, Newborn
Concept RNA, Ribosomal, 16S
Concept Steroids
Concept Cytokines
Concept Receptors, Interleukin-1
Concept Gene Expression Regulation, Developmental
Concept Natriuretic Peptide, Brain
Concept MicroRNAs
Concept Toll-Like Receptors
Concept Toll-Like Receptor 4
Concept Prebiotics
Academic Article Genetic alterations in necrotizing enterocolitis.
Academic Article Outcomes of Infants Who Failed to Extubate despite Systemic Corticosteroids.
Academic Article Single-Immunoglobulin Interleukin-1-Related Receptor regulates vulnerability to TLR4-mediated necrotizing enterocolitis in a mouse model.
Academic Article Usefulness of an Online Risk Estimator for Bronchopulmonary Dysplasia in Predicting Corticosteroid Treatment in Infants Born Preterm.
Academic Article Bowel ultrasound for predicting surgical management of necrotizing enterocolitis: a systematic review and meta-analysis.
Academic Article Bowel Ultrasound for the Diagnosis of Necrotizing Enterocolitis: A Meta-analysis.
Academic Article Genetic predisposition to necrotizing enterocolitis in premature infants: Current knowledge, challenges, and future directions.
Academic Article Timing of postnatal corticosteroid treatment for bronchopulmonary dysplasia and its effect on outcomes.
Academic Article Extended course of prednisolone in infants with severe bronchopulmonary dysplasia.
Academic Article Impact of tracheostomy on language and cognitive development in infants with severe bronchopulmonary dysplasia.
Academic Article NEC-like intestinal injury is ameliorated by Lactobacillus rhamnosus GG in parallel with SIGIRR and A20 induction in neonatal mice.
Academic Article Implementation of bowel ultrasound practice for the diagnosis and management of necrotising enterocolitis.
Academic Article B-type natriuretic peptide and mortality in extremely low birth weight infants with pulmonary hypertension: a retrospective cohort analysis.
Academic Article Clinical dilemma of positive histologic chorioamnionitis in term newborn.
Academic Article Alterations in gene expression and DNA methylation during murine and human lung alveolar septation.
Academic Article Integrated genomic analyses in bronchopulmonary dysplasia.
Academic Article A randomised trial of re-feeding gastric residuals in preterm infants.
Academic Article Regulation of alveolar septation by microRNA-489.
Academic Article A comparison of 7-day versus 10-day course of low-dose dexamethasone for chronically ventilated preterm infants.
Academic Article Quality Improvement Project to Reduce Delayed Vaccinations in Preterm Infants.
Academic Article Using quality improvement to implement consensus guidelines for postnatal steroid treatment of preterm infants with developing bronchopulmonary dysplasia.
Grant Gene-environment interactions in necrotizing enterocolitis: impact of SIGIRR mutation and gut microbiota on intestinal TLR hyperactivity
Academic Article Dynamics of the preterm gut microbiome in health and disease.
Academic Article Effectiveness and safety of repeat dexamethasone for bronchopulmonary dysplasia.
Academic Article A comparison of newer classifications of bronchopulmonary dysplasia: findings from the Children's Hospitals Neonatal Consortium Severe BPD Group.
Academic Article Association of time of first corticosteroid treatment with bronchopulmonary dysplasia in preterm infants.
Academic Article Corticosteroid response predicts bronchopulmonary dysplasia status at 36 weeks in preterm infants treated with dexamethasone: A pilot study.
Academic Article Chronic lung disease in full-term infants: Characteristics and neonatal intensive care outcomes in infants referred to children's hospitals.
Academic Article Feasibility and acceptability of a diagnostic randomized clinical trial of bowel ultrasound in infants with suspected necrotizing enterocolitis.
Academic Article Imaging for Diagnosis and Assessment of Necrotizing Enterocolitis.
Academic Article Necrotizing enterocolitis in premature infants-A defect in the brakes? Evidence from clinical and animal studies.

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