Dactinomycin
"Dactinomycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
| Descriptor ID |
D003609
|
| MeSH Number(s) |
D03.494.200 D04.345.566.252 D12.644.641.252
|
| Concept/Terms |
Cosmegen- Cosmegen
- Lyovac-Cosmegen
- MSD Brand of Dactinomycin
- Merck Frosst Brand of Dactinomycin
- Merck Sharp & Dohme Brand of Dactinomycin
- Cosmegen Lyovac
- Lyovac, Cosmegen
- Merck Brand of Dactinomycin
Ac-De- Ac-De
- Lemery Brand of Dactinomycin
|
Below are MeSH descriptors whose meaning is more general than "Dactinomycin".
Below are MeSH descriptors whose meaning is more specific than "Dactinomycin".
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Below are the most recent publications written about "Dactinomycin" by people in Profiles.
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Lee WM, Lin C, Curran T. Activation of the transforming potential of the human fos proto-oncogene requires message stabilization and results in increased amounts of partially modified fos protein. Mol Cell Biol. 1988 Dec; 8(12):5521-7.