An autosomal dominant disorder with an acronym of its seven features (LENTIGO; ELECTROCARDIOGRAM abnormalities; ocular HYPERTELORISM; PULMONARY STENOSIS; abnormal genitalia; retardation of growth; and DEAFNESS or SENSORINEURAL HEARING LOSS). This syndrome is caused by mutations of PTPN11 gene encoding the non-receptor PROTEIN TYROSINE PHOSPHATASE, type 11, and is an allelic to NOONAN SYNDROME. Features of LEOPARD syndrome overlap with those of NEUROFIBROMATOSIS 1 which is caused by mutations in the NEUROFIBROMATOSIS 1 GENES.

Descriptor ID	D044542
MeSH Number(s)	C05.660.207.525 C14.240.400.695 C14.280.400.695 C14.280.484.716.525 C16.131.077.525 C16.131.240.400.685 C16.131.621.207.525 C17.800.621.430.530.550.525
Concept/Terms	LEOPARD Syndrome LEOPARD Syndrome LEOPARD Syndromes Syndrome, LEOPARD Syndromes, LEOPARD Lentiginosis Cardiomyopathic Cardiomyopathic, Lentiginosis Cardiomyopathics, Lentiginosis Lentiginosis Cardiomyopathics Leopard Syndrome 1 Leopard Syndrome 1s Progressive Cardiomyopathic Lentiginosis Cardiomyopathic Lentiginoses, Progressive Cardiomyopathic Lentiginosis, Progressive Lentiginoses, Progressive Cardiomyopathic Lentiginosis, Progressive Cardiomyopathic Progressive Cardiomyopathic Lentiginoses Multiple Lentigines Syndrome Lentigines Syndrome, Multiple Lentigines Syndromes, Multiple Multiple Lentigines Syndromes Syndrome, Multiple Lentigines Syndromes, Multiple Lentigines Cardio-Cutaneous Syndrome Cardio Cutaneous Syndrome Cardio-Cutaneous Syndromes Syndrome, Cardio-Cutaneous Syndromes, Cardio-Cutaneous Noonan Syndrome with Multiple Lentigines Cardiomyopathic Lentiginosis Cardiomyopathic Lentiginoses Lentiginoses, Cardiomyopathic Lentiginosis, Cardiomyopathic LEOPARD Syndrome, 1 LEOPARD Syndromes, 1 Syndromes, 1 LEOPARD

Below are MeSH descriptors whose meaning is more general than "LEOPARD Syndrome".

Below are MeSH descriptors whose meaning is related to "LEOPARD Syndrome".

Below are MeSH descriptors whose meaning is more specific than "LEOPARD Syndrome".