Integrin alpha6beta1

"Integrin alpha6beta1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

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A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.

Descriptor ID	D039121
MeSH Number(s)	D12.776.395.550.625.419 D12.776.543.550.625.419 D12.776.543.750.705.408.850.674 D12.776.543.750.705.675.514 D12.776.543.750.705.876.500
Concept/Terms	Integrin alpha6beta1 Integrin alpha6beta1 alpha6beta1, Integrin alpha6beta1 Integrin Integrin, alpha6beta1 VLA-6 VLA 6 Integrin alpha(6)beta(1) Platelet Glycoprotein I'c-IIa Glycoprotein I'c-IIa, Platelet I'c-IIa, Platelet Glycoprotein Platelet Glycoprotein I'c IIa alpha 6 beta 1 Integrin CD49f-CD29 CD49f CD29 Integrin alpha6Bbeta1 Integrin alpha6Bbeta1 alpha6Bbeta1, Integrin Integrin alpha6Abeta1 Integrin alpha6Abeta1 alpha6Abeta1, Integrin

Below are MeSH descriptors whose meaning is more general than "Integrin alpha6beta1".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Glycoproteins [D12.776.395]
Membrane Glycoproteins [D12.776.395.550]
Platelet Membrane Glycoproteins [D12.776.395.550.625]
Integrin alpha6beta1 [D12.776.395.550.625.419]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
Platelet Membrane Glycoproteins [D12.776.543.550.625]
Integrin alpha6beta1 [D12.776.543.550.625.419]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Immunologic [D12.776.543.750.705]
Integrins [D12.776.543.750.705.408]
Receptors, Very Late Antigen [D12.776.543.750.705.408.850]
Integrin alpha6beta1 [D12.776.543.750.705.408.850.674]
Platelet Membrane Glycoproteins [D12.776.543.750.705.675]
Integrin alpha6beta1 [D12.776.543.750.705.675.514]
Receptors, Laminin [D12.776.543.750.705.876]
Integrin alpha6beta1 [D12.776.543.750.705.876.500]

Below are MeSH descriptors whose meaning is more specific than "Integrin alpha6beta1".

publications

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