The neonatal form of MULTIPLE CARBOXYLASE DEFICIENCY that is caused by a defect or deficiency in holocarboxylase synthetase. HLCS is the enzyme that covalently links biotin to the biotin dependent carboxylases (propionyl-CoA-carboxylase, pyruvate carboxylase, and beta-methylcrotonyl-CoA carboxylase).

Descriptor ID	D028922
MeSH Number(s)	C16.320.565.100.620.380 C16.320.565.202.720.380 C18.452.648.100.620.380 C18.452.648.202.720.380
Concept/Terms	Holocarboxylase Synthetase Deficiency Holocarboxylase Synthetase Deficiency Deficiencies, Holocarboxylase Synthetase Holocarboxylase Synthetase Deficiencies Deficiency, Holocarboxylase Synthetase Deficiency, Multiple Carboxylase, Neonatal Form HLCS Deficiency Deficiencies, HLCS Deficiency, HLCS HLCS Deficiencies Multiple Carboxylase Deficiency, Neonatal Form Early-Onset Biotin-Responsive Multiple Carboxylase Deficiency Early Onset Biotin Responsive Multiple Carboxylase Deficiency Early-Onset Combined Carboxylase Deficiency Early Onset Combined Carboxylase Deficiency Infantile Multiple Carboxylase Deficiency Carboxylase Deficiency, Multiple, Neonatal Form Multiple Carboxylase Deficiency, Early Onset

Below are MeSH descriptors whose meaning is more general than "Holocarboxylase Synthetase Deficiency".

Below are MeSH descriptors whose meaning is related to "Holocarboxylase Synthetase Deficiency".

Below are MeSH descriptors whose meaning is more specific than "Holocarboxylase Synthetase Deficiency".