Complementarity Determining Regions

"Complementarity Determining Regions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Three regions (CDR1; CDR2 and CDR3) of amino acid sequence in the IMMUNOGLOBULIN VARIABLE REGION that are highly divergent. Together the CDRs from the light and heavy immunoglobulin chains form a surface that is complementary to the antigen. These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors (RECEPTORS, ANTIGEN, T-CELL).

Descriptor ID	D022801
MeSH Number(s)	D12.644.541.500.650.500.180 D12.776.124.486.485.680.650.500.180 D12.776.124.486.485.797.180 D12.776.124.790.651.680.650.500.180 D12.776.124.790.651.797.180 D12.776.377.715.548.680.650.500.180 D12.776.377.715.548.797.180 D12.776.543.750.705.816.824.300 G02.111.570.060.425.160
Concept/Terms	Complementarity Determining Regions Complementarity Determining Regions Region, Complementarity Determining Regions, Complementarity Determining Hypervariable Regions, Immunoglobulin Hypervariable Region, Immunoglobulin Immunoglobulin Hypervariable Region Immunoglobulin Hypervariable Regions Region, Immunoglobulin Hypervariable Regions, Immunoglobulin Hypervariable Complementarity Determining Region Complementarity-Determining Region Complementarity-Determining Regions Regions, Complementarity-Determining Complementarity Determining Region 3 Complementarity Determining Region 3 Complementarity-Determining Region 3 Complementarity-Determining Region 3s Third Complementarity-Determining Region Complementarity-Determining Region, Third Complementarity-Determining Regions, Third Third Complementarity Determining Region Third Complementarity-Determining Regions Complementarity Determining Region III Complementarity Determining Region 1 Complementarity Determining Region 1 Complementarity Determining Region I Complementarity Determining Region 2 Complementarity Determining Region 2 Complementarity Determining Region II

Below are MeSH descriptors whose meaning is more general than "Complementarity Determining Regions".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Peptide Fragments [D12.644.541]
Immunoglobulin Fragments [D12.644.541.500]
Immunoglobulin Fab Fragments [D12.644.541.500.650]
Immunoglobulin Variable Region [D12.644.541.500.650.500]
Complementarity Determining Regions [D12.644.541.500.650.500.180]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Immunoglobulins [D12.776.124.486.485]
Immunoglobulin Fragments [D12.776.124.486.485.680]
Immunoglobulin Fab Fragments [D12.776.124.486.485.680.650]
Immunoglobulin Variable Region [D12.776.124.486.485.680.650.500]
Complementarity Determining Regions [D12.776.124.486.485.680.650.500.180]
Immunoglobulin Variable Region [D12.776.124.486.485.797]
Complementarity Determining Regions [D12.776.124.486.485.797.180]
Serum Globulins [D12.776.124.790]
Immunoglobulins [D12.776.124.790.651]
Immunoglobulin Fragments [D12.776.124.790.651.680]
Immunoglobulin Fab Fragments [D12.776.124.790.651.680.650]
Immunoglobulin Variable Region [D12.776.124.790.651.680.650.500]
Complementarity Determining Regions [D12.776.124.790.651.680.650.500.180]
Immunoglobulin Variable Region [D12.776.124.790.651.797]
Complementarity Determining Regions [D12.776.124.790.651.797.180]
Globulins [D12.776.377]
Serum Globulins [D12.776.377.715]
Immunoglobulins [D12.776.377.715.548]
Immunoglobulin Fragments [D12.776.377.715.548.680]
Immunoglobulin Fab Fragments [D12.776.377.715.548.680.650]
Immunoglobulin Variable Region [D12.776.377.715.548.680.650.500]
Complementarity Determining Regions [D12.776.377.715.548.680.650.500.180]
Immunoglobulin Variable Region [D12.776.377.715.548.797]
Complementarity Determining Regions [D12.776.377.715.548.797.180]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Immunologic [D12.776.543.750.705]
Receptors, Antigen [D12.776.543.750.705.816]
Receptors, Antigen, T-Cell [D12.776.543.750.705.816.824]
Complementarity Determining Regions [D12.776.543.750.705.816.824.300]
Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Amino Acid Sequence [G02.111.570.060]
Immunoglobulin Variable Region [G02.111.570.060.425]
Complementarity Determining Regions [G02.111.570.060.425.160]

Below are MeSH descriptors whose meaning is related to "Complementarity Determining Regions".

Below are MeSH descriptors whose meaning is more specific than "Complementarity Determining Regions".

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