P-Glycoproteins
"P-Glycoproteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to P-GLYCOPROTEIN. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
| Descriptor ID |
D018435
|
| MeSH Number(s) |
D12.776.157.530.100.652 D12.776.157.530.450.074.500.500.875 D12.776.395.550.020.610 D12.776.543.550.192.610 D12.776.543.585.100.610 D12.776.543.585.450.074.500.500.875
|
| Concept/Terms |
P-Glycoproteins- P-Glycoproteins
- P Glycoproteins
- ATP-Binding Cassette, Sub-Family B Proteins
- ATP Binding Cassette, Sub Family B Proteins
- Multidrug Resistance Proteins
|
Below are MeSH descriptors whose meaning is more general than "P-Glycoproteins".
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