 Leucine Zippers
"Leucine Zippers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). The DNA-binding residues are located in the bifurcated region of the Y.
| Descriptor ID |
D016350
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| MeSH Number(s) |
G02.111.570.820.709.600.040.520
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| Concept/Terms |
Leucine Zippers- Leucine Zippers
- Leucine Zipper
- Zipper, Leucine
- Zippers, Leucine
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Below are MeSH descriptors whose meaning is more general than "Leucine Zippers".
Below are MeSH descriptors whose meaning is more specific than "Leucine Zippers".
This graph shows the total number of publications written about "Leucine Zippers" by people in this website by year, and whether "Leucine Zippers" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
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Below are the most recent publications written about "Leucine Zippers" by people in Profiles.
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McKenzie FR, Connelly MA, Balzarano D, M?ller JR, Geleziunas R, Marcu KB. Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements. Mol Cell Biol. 2000 Apr; 20(8):2635-49.
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Kerppola TK, Curran T. The transcription activation domains of Fos and Jun induce DNA bending through electrostatic interactions. EMBO J. 1997 May 15; 16(10):2907-16.
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Kerppola T, Curran T. Transcription. Zen and the art of Fos and Jun. Nature. 1995 Jan 19; 373(6511):199-200.
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Kerppola TK, Curran T. Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun. Oncogene. 1994 Mar; 9(3):675-84.
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Hsu W, Kerppola TK, Chen PL, Curran T, Chen-Kiang S. Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region. Mol Cell Biol. 1994 Jan; 14(1):268-76.
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Kerppola TK, Curran T. Selective DNA bending by a variety of bZIP proteins. Mol Cell Biol. 1993 Sep; 13(9):5479-89.
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Curran T, Abate C, Baker S, Kerppola T, Xanthoudakis S. The regulation of c-fos: too much is never enough. Adv Second Messenger Phosphoprotein Res. 1993; 28:271-7.
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Curran T. Fos and Jun: oncogenic transcription factors. Tohoku J Exp Med. 1992 Oct; 168(2):169-74.
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Kerppola TK, Curran T. DNA bending by Fos and Jun: the flexible hinge model. Science. 1991 Nov 22; 254(5035):1210-4.
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Morgan JI, Curran T. Proto-oncogene transcription factors and epilepsy. Trends Pharmacol Sci. 1991 Sep; 12(9):343-9.
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