Lymphocyte Function-Associated Antigen-1

"Lymphocyte Function-Associated Antigen-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (ANTIGENS, CD18) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.

Descriptor ID	D016169
MeSH Number(s)	D12.776.395.550.200.625.550 D12.776.543.550.200.625.550 D12.776.543.750.705.408.600.400 D12.776.543.750.705.877.550 D23.050.301.264.035.111.400 D23.050.301.264.035.850.550 D23.050.301.350.625.550 D23.101.100.110.111.400 D23.101.100.110.850.550
Concept/Terms	Lymphocyte Function-Associated Antigen-1 Lymphocyte Function-Associated Antigen-1 Antigen-1, Lymphocyte Function-Associated Leukocyte Function Associated Antigen-1 LFA-1 Integrin alphaLbeta2 alphaLbeta2, Integrin

Below are MeSH descriptors whose meaning is more general than "Lymphocyte Function-Associated Antigen-1".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Glycoproteins [D12.776.395]
Membrane Glycoproteins [D12.776.395.550]
Cell Adhesion Molecules [D12.776.395.550.200]
Receptors, Lymphocyte Homing [D12.776.395.550.200.625]
Lymphocyte Function-Associated Antigen-1 [D12.776.395.550.200.625.550]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
Cell Adhesion Molecules [D12.776.543.550.200]
Receptors, Lymphocyte Homing [D12.776.543.550.200.625]
Lymphocyte Function-Associated Antigen-1 [D12.776.543.550.200.625.550]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Immunologic [D12.776.543.750.705]
Integrins [D12.776.543.750.705.408]
Receptors, Leukocyte-Adhesion [D12.776.543.750.705.408.600]
Lymphocyte Function-Associated Antigen-1 [D12.776.543.750.705.408.600.400]
Receptors, Lymphocyte Homing [D12.776.543.750.705.877]
Lymphocyte Function-Associated Antigen-1 [D12.776.543.750.705.877.550]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Surface [D23.050.301]
Antigens, Differentiation [D23.050.301.264]
Antigens, CD [D23.050.301.264.035]
Antigens, CD11 [D23.050.301.264.035.111]
Lymphocyte Function-Associated Antigen-1 [D23.050.301.264.035.111.400]
Receptors, Lymphocyte Homing [D23.050.301.264.035.850]
Lymphocyte Function-Associated Antigen-1 [D23.050.301.264.035.850.550]
Cell Adhesion Molecules [D23.050.301.350]
Receptors, Lymphocyte Homing [D23.050.301.350.625]
Lymphocyte Function-Associated Antigen-1 [D23.050.301.350.625.550]
Biomarkers [D23.101]
Antigens, Differentiation [D23.101.100]
Antigens, CD [D23.101.100.110]
Antigens, CD11 [D23.101.100.110.111]
Lymphocyte Function-Associated Antigen-1 [D23.101.100.110.111.400]
Receptors, Lymphocyte Homing [D23.101.100.110.850]
Lymphocyte Function-Associated Antigen-1 [D23.101.100.110.850.550]

Below are MeSH descriptors whose meaning is related to "Lymphocyte Function-Associated Antigen-1".

Below are MeSH descriptors whose meaning is more specific than "Lymphocyte Function-Associated Antigen-1".

publications

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