55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.

Descriptor ID	D015704
MeSH Number(s)	D12.776.543.750.705.852.420.810.500 D12.776.543.750.925.700.025 D23.050.301.264.035.104 D23.050.301.264.894.100 D23.101.100.110.104 D23.101.100.894.100
Concept/Terms	Antigens, CD4 Antigens, CD4 CD4 Receptors Receptors, CD4 T4 Antigens, T-Cell Antigens, T-Cell T4 T-Cell T4 Antigens T4 Antigens, T Cell Surface CD4 Receptor CD4 Receptor, Surface CD4 Antigen Antigen, CD4 CD4 Antigens CD4 Molecule Receptors, Surface CD4 CD4 Receptors, Surface Surface CD4 Receptors

Below are MeSH descriptors whose meaning is more general than "Antigens, CD4".

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Below are MeSH descriptors whose meaning is more specific than "Antigens, CD4".