A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)

Descriptor ID	D015419
MeSH Number(s)	C10.500.300.820 C10.574.500.495.820 C10.668.829.800.300.820 C16.131.666.300.820 C16.320.400.375.820
Concept/Terms	Spastic Paraplegia, Hereditary Spastic Paraplegia, Hereditary Hereditary Spastic Paraplegias Paraplegia, Hereditary Spastic Paraplegias, Hereditary Spastic Spastic Paraplegias, Hereditary Hereditary Motor and Sensory Neuropathy 5 Hereditary Motor And Sensory Neuropathy V Hereditary Motor-Sensory Neuropathy with Pyramidal Signs Hereditary Motor Sensory Neuropathy with Pyramidal Signs Hereditary Spastic Paraplegia Type V Hereditary Motor and Sensory Neuropathy HMSN Type V Type V, HMSN HMSN V HMSN V (Hereditary Motor and Sensory Neuropathy Type V) Hypertrophic Motor-Sensory Neuropathy-Spastic Paraplegia Hypertrophic Motor Sensory Neuropathy Spastic Paraplegia Paraplegia, Spastic, Hereditary Spastic Paraplegia-Hypertrophic Motor-Sensory Neuropathy Spastic Paraplegia Hypertrophic Motor Sensory Neuropathy CMT with Pyramidal Features HMSN 5 X-Linked, Spastic Paraplegia, Hereditary X-Linked, Spastic Paraplegia, Hereditary Hereditary X-Linked Recessive Spastic Paraplegia Hereditary X-Linked Recessive Spastic Paraplegia Hereditary X Linked Recessive Spastic Paraplegia Spastic Paraplegia 2 X-linked Recessive Hereditary Spastic Paraplegia Spastic Paraplegia, Hereditary, X-Linked Recessive Spastic Paraplegia, X-Linked Recessive, Hereditary X Linked Recessive Hereditary Spastic Paraplegia Hereditary, Spastic Paraplegia, X-Linked Recessive Spastic Paraplegia Type 2 Autosomal Recessive Hereditary Spastic Paraplegia Autosomal Recessive Hereditary Spastic Paraplegia Spastic Paraplegia, Hereditary, Autosomal Recessive Hereditary Spastic Paraplegia, Autosomal Recessive Spastic Paraplegia, Autosomal Recessive, Hereditary Autosomal Recessive Spastic Paraplegia, Hereditary Hereditary Autosomal Recessive Spastic Paraplegia Hereditary Autosomal Dominant Spastic Paraplegia Hereditary Autosomal Dominant Spastic Paraplegia Autosomal Dominant Spastic Paraplegia Hereditary Spastic Paraplegia, Hereditary, Autosomal Dominant Hereditary, Spastic Paraplegia, Autosomal Dominant Peroneal Muscular Atrophy with Pyramidal Features, Autosomal Dominant Spastic Paraplegia, Autosomal Dominant, Hereditary Autosomal Dominant Hereditary Spastic Paraplegia Charcot-Marie-Tooth Disease with Pyramidal Features, Autosomal Dominant Charcot Marie Tooth Disease with Pyramidal Features, Autosomal Dominant

Below are MeSH descriptors whose meaning is more general than "Spastic Paraplegia, Hereditary".

Below are MeSH descriptors whose meaning is related to "Spastic Paraplegia, Hereditary".

Below are MeSH descriptors whose meaning is more specific than "Spastic Paraplegia, Hereditary".