 Thioguanine
"Thioguanine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
| Descriptor ID |
D013866
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| MeSH Number(s) |
D03.438.759.854
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| Concept/Terms |
Thioguanine- Thioguanine
- 6-Thioguanine
- 6 Thioguanine
- Tioguanine
- 2-Amino-6-Purinethiol
- 2 Amino 6 Purinethiol
Tabloid- Tabloid
- Thioguanine Tabloid
- Thioguanin-GSK
- Thioguanin GSK
- ThioguaninGSK
- GlaxoSmithKline Brand of Thioguanine
- GlaxoSmithKline Brand of Tioguanine
- Tioguanine GlaxoSmithKline Brand
Lanvis- Lanvis
- Glaxo Wellcome Brand of Tioguanine
- Glaxo Wellcome Brand of Thioguanine
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Below are MeSH descriptors whose meaning is more general than "Thioguanine".
Below are MeSH descriptors whose meaning is more specific than "Thioguanine".
This graph shows the total number of publications written about "Thioguanine" by people in this website by year, and whether "Thioguanine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 | | 2010 | 2 | 0 | 2 | | 2011 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Thioguanine" by people in Profiles.
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Higgerson K, Flatt T. Skin Toxicity Due to Mercaptopurine in Maintenance Therapy Among Children With Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2023 05 01; 45(4):e514-e517.
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Matimba A, Li F, Livshits A, Cartwright CS, Scully S, Fridley BL, Jenkins G, Batzler A, Wang L, Weinshilboum R, Lennard L. Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes. Pharmacogenomics. 2014 Mar; 15(4):433-47.
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Lacayo NJ, Alonzo TA, Gayko U, Rosen DB, Westfall M, Purvis N, Putta S, Louie B, Hackett J, Cohen AC, Cesano A, Gerbing R, Ravindranath Y, Dahl GV, Gamis A, Meshinchi S. Development and validation of a single-cell network profiling assay-based classifier to predict response to induction therapy in paediatric patients with de novo acute myeloid leukaemia: a report from the Children's Oncology Group. Br J Haematol. 2013 Jul; 162(2):250-62.
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Sorrell AD, Alonzo TA, Hilden JM, Gerbing RB, Loew TW, Hathaway L, Barnard D, Taub JW, Ravindranath Y, Smith FO, Arceci RJ, Woods WG, Gamis AS. Favorable survival maintained in children who have myeloid leukemia associated with Down syndrome using reduced-dose chemotherapy on Children's Oncology Group trial A2971: a report from the Children's Oncology Group. Cancer. 2012 Oct 01; 118(19):4806-14.
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Fridley BL, Batzler A, Li L, Li F, Matimba A, Jenkins GD, Ji Y, Wang L, Weinshilboum RM. Gene set analysis of purine and pyrimidine antimetabolites cancer therapies. Pharmacogenet Genomics. 2011 Nov; 21(11):701-12.
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Fridley BL, Jenkins GD, Batzler A, Wang L, Ji Y, Li F, Weinshilboum RM. Multivariate models to detect genomic signatures for a class of drugs: application to thiopurines pharmacogenomics. Pharmacogenomics J. 2012 Apr; 12(2):105-10.
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Li F, Fridley BL, Matimba A, Kalari KR, Pelleymounter L, Moon I, Ji Y, Jenkins GD, Batzler A, Wang L, Weinshilboum RM. Ecto-5'-nucleotidase and thiopurine cellular circulation: association with cytotoxicity. Drug Metab Dispos. 2010 Dec; 38(12):2329-38.
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Srivastava T, O'Neill JP, Dasouki M, Simckes AM. Childhood hyperuricemia and acute renal failure resulting from a missense mutation in the HPRT gene. Am J Med Genet. 2002 Mar 15; 108(3):219-22.
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