 Mycophenolic Acid
"Mycophenolic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antibiotic substance derived from Penicillium stoloniferum, and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. Mycophenolic acid is important because of its selective effects on the immune system. It prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells. It also may inhibit recruitment of leukocytes to inflammatory sites. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1301)
| Descriptor ID |
D009173
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| MeSH Number(s) |
D02.241.081.193.678 D10.251.618
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Mycophenolic Acid".
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This graph shows the total number of publications written about "Mycophenolic Acid" by people in this website by year, and whether "Mycophenolic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mycophenolic Acid" by people in Profiles.
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Banerjee D, Burkard L, Panepinto JC. Inhibition of nucleotide biosynthesis potentiates the antifungal activity of amphotericin B. PLoS One. 2014; 9(1):e87246.
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Polk BI, Becker ML. Pharmacogenomics in childhood rheumatic disorders: a foundation for future individualized therapy. Discov Med. 2013 Dec; 16(90):267-75.
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Hogg RJ, Friedman A, Greene T, Radeva M, Budisavljevic MN, Gassman J, Gipson DS, Jefferson JA, John EG, Kaskel FJ, Moudgil A, Moxey-Mims M, Ortiz LA, Schelling JR, Schnaper W, Srivastava T, Trachtman H, Vehaskari VM, Wong C, Woronieki RP, Van Why SK, Zolotnitskaya A. Renal function and proteinuria after successful immunosuppressive therapies in patients with FSGS. Clin J Am Soc Nephrol. 2013 Feb; 8(2):211-8.
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Becker ML. Pharmacogenomics in pediatric rheumatology. Curr Opin Rheumatol. 2012 Sep; 24(5):541-7.
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Wu TY, Fridley BL, Jenkins GD, Batzler A, Wang L, Weinshilboum RM. Mycophenolic acid response biomarkers: a cell line model system-based genome-wide screen. Int Immunopharmacol. 2011 Aug; 11(8):1057-64.
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Bryan CF, Nelson PW, Shield CF, Warady BA, Winklhofer FT, Murillo D, Wakefield MR. Long-term survival of kidneys transplanted from live A2 donors to O and B recipients. Am J Transplant. 2007 May; 7(5):1181-4.
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Srivastava T, Garola RE, Kestila M, Tryggvason K, Ruotsalainen V, Sharma M, Savin VJ, Jalanko H, Warady BA. Recurrence of proteinuria following renal transplantation in congenital nephrotic syndrome of the Finnish type. Pediatr Nephrol. 2006 May; 21(5):711-8.
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