Loading...
Keywords
Last Name
Institution

Tomoo Iwakuma, MD, PhD

TitleProfessor and Director, Translational Laboratory Oncology Research
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gilham Rd
Kansas City MO 64108
vCardDownload vCard
    Other Positions
    TitleProfessor of Pediatrics
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics

    TitleResearch Professor of Cancer Biology
    InstitutionUniversity of Kansas Medical Center
    DepartmentBiology


    Collapse Biography 
    Collapse education and training
    Kyushu University, Fukuoka, JapanMD, PhD
    Kyushu University, Fukuoka, JapanResidency
    Baylor College of Medicine, Waco, TXPost Doctorial
    MD Anderson Cancer Center, HoustonPost Doctorial

    Collapse Research 
    Collapse research overview
    Dr. Iwakuma's primary research focuses on the field of Cancer Research, especially dissecting the mechanism of cancer progression and discovering novel drugs or compounds that specifically kill cancer cells, with special focus on the tumor suppressor p53 pathway.
    Collapse research activities and funding
    R01CA174735     (IWAKUMA, TOMOO)May 1, 2014 - Apr 30, 2020
    NIH
    The role of MDM2-MTBP axis in cancer metastasis
    Role: Principal Investigator

    R01CA214916     (IWAKUMA, TOMOO)Mar 9, 2018 - Feb 28, 2023
    NIH
    Control of mutant p53 stability via the mevalonate pathway-DNAJA1 axis
    Role: Principal Investigator

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Kaida A, Yamamoto S, Parrales A, Young ED, Ranjan A, Alalem MA, Morita KI, Oikawa Y, Harada H, Ikeda T, Thomas SM, Diaz FJ, Iwakuma T. DNAJA1 promotes cancer metastasis through interaction with mutant p53. Oncogene. 2021 Jun 28. PMID: 34183772.
      View in: PubMed
    2. Liang Y, Lyon RC, Pellman J, Bradford WH, Lange S, Bogomolovas J, Dalton ND, Gu Y, Bobar M, Lee MH, Iwakuma T, Nigam V, Asimaki A, Scheinman M, Peterson KL, Sheikh F. Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Clin Invest. 2021 Jun 01; 131(11). PMID: 33857019.
      View in: PubMed
    3. Ghosh M, Saha S, Bettke J, Nagar R, Parrales A, Iwakuma T, van der Velden AWM, Martinez LA. Mutant p53 suppresses innate immune signaling to promote tumorigenesis. Cancer Cell. 2021 Apr 12; 39(4):494-508.e5. PMID: 33545063.
      View in: PubMed
    4. Young ED, Manley SJ, Beadnell TC, Shearin AE, Sasaki K, Zimmerman R, Kauffman E, Vivian CJ, Parasuram A, Iwakuma T, Grandgenett PM, Hollingsworth MA, O'Neil M, Welch DR. Suppression of pancreatic cancer liver metastasis by secretion-deficient ITIH5. Br J Cancer. 2021 01; 124(1):166-175. PMID: 33024269.
      View in: PubMed
    5. Parrales A, Iwakuma T. TAp63-miRNA-AURKA Axis as a Therapeutic Target for Cutaneous Squamous Cell Carcinoma. Cancer Res. 2020 06 15; 80(12):2439-2440. PMID: 32540854.
      View in: PubMed
    6. Subramaniam D, Angulo P, Ponnurangam S, Dandawate P, Ramamoorthy P, Srinivasan P, Iwakuma T, Weir SJ, Chastain K, Anant S. Suppressing STAT5 signaling affects osteosarcoma growth and stemness. Cell Death Dis. 2020 02 24; 11(2):149. PMID: 32094348.
      View in: PubMed
    7. Dandawate P, Ghosh C, Palaniyandi K, Paul S, Rawal S, Pradhan R, Sayed AAA, Choudhury S, Standing D, Subramaniam D, Padhye SB, Gunewardena S, Thomas SM, Neil MO, Tawfik O, Welch DR, Jensen RA, Maliski S, Weir S, Iwakuma T, Anant S, Dhar A. The Histone Demethylase KDM3A, Increased in Human Pancreatic Tumors, Regulates Expression of DCLK1 and Promotes Tumorigenesis in Mice. Gastroenterology. 2019 12; 157(6):1646-1659.e11. PMID: 31442435.
      View in: PubMed
    8. Thoenen E, Curl A, Iwakuma T. TP53 in bone and soft tissue sarcomas. Pharmacol Ther. 2019 10; 202:149-164. PMID: 31276706.
      View in: PubMed
    9. Han Y, Wu P, Wang Z, Zhang Z, Sun S, Liu J, Gong S, Gao P, Iwakuma T, Molina-Vila MA, Chen BP, Zhang Y, Ji T, Mo Q, Chen P, Hu J, Wang S, Zhou J, Lu H, Gao Q. Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation. EBioMedicine. 2019 Feb; 40:92-105. PMID: 30674441.
      View in: PubMed
    10. Yamamoto S, Iwakuma T. Regulators of Oncogenic Mutant TP53 Gain of Function. Cancers (Basel). 2018 Dec 20; 11(1). PMID: 30577483.
      View in: PubMed
    11. Ranjan A, Iyer SV, Ward C, Link T, Diaz FJ, Dhar A, Tawfik OW, Weinman SA, Azuma Y, Izumi T, Iwakuma T. MTBP inhibits the Erk1/2-Elk-1 signaling in hepatocellular carcinoma. Oncotarget. 2018 Apr 20; 9(30):21429-21443. PMID: 29765550.
      View in: PubMed
    12. Ranjan A, Iwakuma T. Emerging Non-Canonical Functions and Regulation of p53. Int J Mol Sci. 2018 Mar 28; 19(4). PMID: 29597309.
      View in: PubMed
    13. Parrales A, McDonald P, Ottomeyer M, Roy A, Shoenen FJ, Broward M, Bruns T, Thamm DH, Weir SJ, Neville KA, Iwakuma T, Fulbright JM. Comparative oncology approach to drug repurposing in osteosarcoma. PLoS One. 2018; 13(3):e0194224. PMID: 29579058.
      View in: PubMed
    14. Parrales A, Thoenen E, Iwakuma T. The interplay between mutant p53 and the mevalonate pathway. Cell Death Differ. 2018 03; 25(3):460-470. PMID: 29238070.
      View in: PubMed
    15. Dong S, Baranwal S, Garcia A, Serrano-Gomez SJ, Eastlack S, Iwakuma T, Mercante D, Mauvais-Jarvis F, Alahari SK. Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase. J Biol Chem. 2017 10 13; 292(41):16833-16846. PMID: 28842496.
      View in: PubMed
    16. Kundu AK, Iyer SV, Chandra S, Adhikari AS, Iwakuma T, Mandal TK. Novel siRNA formulation to effectively knockdown mutant p53 in osteosarcoma. PLoS One. 2017; 12(6):e0179168. PMID: 28636657.
      View in: PubMed
    17. Link T, Iwakuma T. Roles of p53 in extrinsic factor-induced liver carcinogenesis. Hepatoma Res. 2017; 3:95-104. PMID: 30123836.
      View in: PubMed
    18. Parrales A, Ranjan A, Iwakuma T. Unsaturated fatty acids regulate stemness of ovarian cancer cells through NF-?B. Stem Cell Investig. 2017; 4:49. PMID: 28607923.
      View in: PubMed
    19. Yamamoto S, Iwakuma T. RIPK1-TRAF2 interplay on the TNF/NF-?B signaling, cell death, and cancer development in the liver. Transl Cancer Res. 2017 May; 6(Suppl 3):94-109. PMID: 30123738.
      View in: PubMed
    20. Ranjan A, Iyer SV, Iwakuma T. Suppressive roles of A3AR and TMIGD3 i1 in osteosarcoma malignancy. . 2017 05 19; 16(10):903-904. PMID: 28355102.
      View in: PubMed
    21. Sasaki K, Kurahara H, Young ED, Natsugoe S, Ijichi A, Iwakuma T, Welch DR. Genome-wide in vivo RNAi screen identifies ITIH5 as a metastasis suppressor in pancreatic cancer. Clin Exp Metastasis. 2017 04; 34(3-4):229-239. PMID: 28289921.
      View in: PubMed
    22. Parrales A, Iwakuma T. p53 as a Regulator of Lipid Metabolism in Cancer. Int J Mol Sci. 2016 Dec 10; 17(12). PMID: 27973397.
      View in: PubMed
    23. Ranjan A, Iwakuma T. Non-Canonical Cell Death Induced by p53. Int J Mol Sci. 2016 Dec 09; 17(12). PMID: 27941671.
      View in: PubMed
    24. Braun MW, Iwakuma T. Regulation of cytotoxic T-cell responses by p53 in cancer. Transl Cancer Res. 2016 Dec; 5(6):692-697. PMID: 28944167.
      View in: PubMed
    25. Iyer SV, Ranjan A, Elias HK, Parrales A, Sasaki H, Roy BC, Umar S, Tawfik OW, Iwakuma T. Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-?B and osteosarcoma progression. Nat Commun. 2016 11 25; 7:13561. PMID: 27886186.
      View in: PubMed
    26. Parrales A, Ranjan A, Iyer SV, Padhye S, Weir SJ, Roy A, Iwakuma T. DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway. Nat Cell Biol. 2016 Nov; 18(11):1233-1243. PMID: 27775703.
      View in: PubMed
    27. Kurahara H, Bohl C, Natsugoe S, Nishizono Y, Harihar S, Sharma R, Iwakuma T, Welch DR. Suppression of pancreatic cancer growth and metastasis by HMP19 identified through genome-wide shRNA screen. Int J Cancer. 2016 08 01; 139(3):628-38. PMID: 27012470.
      View in: PubMed
    28. Ranjan A, Bera K, Iwakuma T. Murine double minute 2, a potential p53-independent regulator of liver cancer metastasis. Hepatoma Res. 2016; 2:114-121. PMID: 28944296.
      View in: PubMed
    29. Iyer SV, Parrales A, Begani P, Narkar A, Adhikari AS, Martinez LA, Iwakuma T. Allele-specific silencing of mutant p53 attenuates dominant-negative and gain-of-function activities. Oncotarget. 2016 Feb 02; 7(5):5401-15. PMID: 26700961.
      View in: PubMed
    30. Parrales A, Iwakuma T. Targeting Oncogenic Mutant p53 for Cancer Therapy. Front Oncol. 2015; 5:288. PMID: 26732534.
      View in: PubMed
    31. Sasaki H, Iyer SV, Sasaki K, Tawfik OW, Iwakuma T. An improved intrafemoral injection with minimized leakage as an orthotopic mouse model of osteosarcoma. Anal Biochem. 2015 Oct 01; 486:70-4. PMID: 26142221.
      View in: PubMed
    32. Bi Q, Ranjan A, Fan R, Agarwal N, Welch DR, Weinman SA, Ding J, Iwakuma T. MTBP inhibits migration and metastasis of hepatocellular carcinoma. Clin Exp Metastasis. 2015 Apr; 32(4):301-11. PMID: 25759210.
      View in: PubMed
    33. Harihar S, Pounds KM, Iwakuma T, Seidah NG, Welch DR. Furin is the major proprotein convertase required for KISS1-to-Kisspeptin processing. PLoS One. 2014; 9(1):e84958. PMID: 24454770.
      View in: PubMed
    34. Liu W, Beck BH, Vaidya KS, Nash KT, Feeley KP, Ballinger SW, Pounds KM, Denning WL, Diers AR, Landar A, Dhar A, Iwakuma T, Welch DR. Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis. Cancer Res. 2014 Feb 01; 74(3):954-63. PMID: 24351292.
      View in: PubMed
    35. Iwakuma T, Agarwal N. MDM2 binding protein, a novel metastasis suppressor. Cancer Metastasis Rev. 2012 Dec; 31(3-4):633-40. PMID: 22684342.
      View in: PubMed
    36. Iyer SV, Iwakuma T. A novel link between the HER2-Akt and MDM2-p53 pathways via CSN6. . 2012 Nov 15; 11(22):4112. PMID: 23099920.
      View in: PubMed
    37. Agarwal N, Adhikari AS, Iyer SV, Hekmatdoost K, Welch DR, Iwakuma T. MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4. Oncogene. 2013 Jan 24; 32(4):462-70. PMID: 22370640.
      View in: PubMed
    38. Kibe R, Zhang S, Guo D, Marrero L, Tsien F, Rodriguez P, Khan S, Zieske A, Huang J, Li W, Durum SK, Iwakuma T, Cui Y. IL-7Ra deficiency in p53null mice exacerbates thymocyte telomere erosion and lymphomagenesis. Cell Death Differ. 2012 Jul; 19(7):1139-51. PMID: 22281704.
      View in: PubMed
    39. Pant V, Xiong S, Iwakuma T, Quintás-Cardama A, Lozano G. Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11995-2000. PMID: 21730132.
      View in: PubMed
    40. Zhang S, Zheng M, Kibe R, Huang Y, Marrero L, Warren S, Zieske AW, Iwakuma T, Kolls JK, Cui Y. Trp53 negatively regulates autoimmunity via the STAT3-Th17 axis. FASEB J. 2011 Jul; 25(7):2387-98. PMID: 21471252.
      View in: PubMed
    41. Zhao R, Yeung SC, Chen J, Iwakuma T, Su CH, Chen B, Qu C, Zhang F, Chen YT, Lin YL, Lee DF, Jin F, Zhu R, Shaikenov T, Sarbassov D, Sahin A, Wang H, Wang H, Lai CC, Tsai FJ, Lozano G, Lee MH. Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. J Clin Invest. 2011 Mar; 121(3):851-65. PMID: 21317535.
      View in: PubMed
    42. Agarwal N, Tochigi Y, Adhikari AS, Cui S, Cui Y, Iwakuma T. MTBP plays a crucial role in mitotic progression and chromosome segregation. Cell Death Differ. 2011 Jul; 18(7):1208-19. PMID: 21274008.
      View in: PubMed
    43. Adhikari AS, Agarwal N, Iwakuma T. Metastatic potential of tumor-initiating cells in solid tumors. Front Biosci (Landmark Ed). 2011 Jan 01; 16:1927-38. PMID: 21196274.
      View in: PubMed
    44. Post SM, Quintás-Cardama A, Pant V, Iwakuma T, Hamir A, Jackson JG, Maccio DR, Bond GL, Johnson DG, Levine AJ, Lozano G. A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development. Cancer Cell. 2010 Sep 14; 18(3):220-30. PMID: 20832750.
      View in: PubMed
    45. Adhikari AS, Agarwal N, Wood BM, Porretta C, Ruiz B, Pochampally RR, Iwakuma T. CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance. Cancer Res. 2010 Jun 01; 70(11):4602-12. PMID: 20460510.
      View in: PubMed
    46. Odvody J, Vincent T, Arrate MP, Grieb B, Wang S, Garriga J, Lozano G, Iwakuma T, Haines DS, Eischen CM. A deficiency in Mdm2 binding protein inhibits Myc-induced B-cell proliferation and lymphomagenesis. Oncogene. 2010 Jun 03; 29(22):3287-96. PMID: 20305689.
      View in: PubMed
    47. Adhikari AS, Iwakuma T. Mutant p53 gain of oncogenic function: in vivo evidence, mechanism of action and its clinical implications. Fukuoka Igaku Zasshi. 2009 Jun; 100(6):217-28. PMID: 19670804.
      View in: PubMed
    48. Busso CS, Iwakuma T, Izumi T. Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway. Oncogene. 2009 Apr 02; 28(13):1616-25. PMID: 19219073.
      View in: PubMed
    49. Barboza JA, Iwakuma T, Terzian T, El-Naggar AK, Lozano G. Mdm2 and Mdm4 loss regulates distinct p53 activities. Mol Cancer Res. 2008 Jun; 6(6):947-54. PMID: 18567799.
      View in: PubMed
    50. Terzian T, Suh YA, Iwakuma T, Post SM, Neumann M, Lang GA, Van Pelt CS, Lozano G. The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss. Genes Dev. 2008 May 15; 22(10):1337-44. PMID: 18483220.
      View in: PubMed
    51. Iwakuma T, Tochigi Y, Van Pelt CS, Caldwell LC, Terzian T, Parant JM, Chau GP, Koch JG, Eischen CM, Lozano G. Mtbp haploinsufficiency in mice increases tumor metastasis. Oncogene. 2008 Mar 20; 27(13):1813-20. PMID: 17906694.
      View in: PubMed
    52. Iwakuma T, Lozano G. Crippling p53 activities via knock-in mutations in mouse models. Oncogene. 2007 Apr 02; 26(15):2177-84. PMID: 17401426.
      View in: PubMed
    53. Iwakuma T, Lozano G, Flores ER. Li-Fraumeni syndrome: a p53 family affair. . 2005 Jul; 4(7):865-7. PMID: 15917654.
      View in: PubMed
    54. Lang GA, Iwakuma T, Suh YA, Liu G, Rao VA, Parant JM, Valentin-Vega YA, Terzian T, Caldwell LC, Strong LC, El-Naggar AK, Lozano G. Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell. 2004 Dec 17; 119(6):861-72. PMID: 15607981.
      View in: PubMed
    55. Iwakuma T, Parant JM, Fasulo M, Zwart E, Jacks T, de Vries A, Lozano G. Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice. Oncogene. 2004 Oct 07; 23(46):7644-50. PMID: 15361844.
      View in: PubMed
    56. Bruins W, Zwart E, Attardi LD, Iwakuma T, Hoogervorst EM, Beems RB, Miranda B, van Oostrom CT, van den Berg J, van den Aardweg GJ, Lozano G, van Steeg H, Jacks T, de Vries A. Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389. Mol Cell Biol. 2004 Oct; 24(20):8884-94. PMID: 15456863.
      View in: PubMed
    57. Iwakuma T, Lozano G. MDM2, an introduction. Mol Cancer Res. 2003 Dec; 1(14):993-1000. PMID: 14707282.
      View in: PubMed
    58. Tsuzuki T, Egashira A, Igarashi H, Iwakuma T, Nakatsuru Y, Tominaga Y, Kawate H, Nakao K, Nakamura K, Ide F, Kura S, Nakabeppu Y, Katsuki M, Ishikawa T, Sekiguchi M. Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11456-61. PMID: 11572992.
      View in: PubMed
    59. Zhu K, Henning D, Iwakuma T, Valdez BC, Busch H. Adriamycin inhibits human RH II/Gu RNA helicase activity by binding to its substrate. Biochem Biophys Res Commun. 1999 Dec 20; 266(2):361-5. PMID: 10600508.
      View in: PubMed
    60. Iwakuma T, Cui Y, Chang LJ. Self-inactivating lentiviral vectors with U3 and U5 modifications. Virology. 1999 Aug 15; 261(1):120-32. PMID: 10441560.
      View in: PubMed
    61. Cui Y, Iwakuma T, Chang LJ. Contributions of viral splice sites and cis-regulatory elements to lentivirus vector function. J Virol. 1999 Jul; 73(7):6171-6. PMID: 10364378.
      View in: PubMed
    62. Chang LJ, Urlacher V, Iwakuma T, Cui Y, Zucali J. Efficacy and safety analyses of a recombinant human immunodeficiency virus type 1 derived vector system. Gene Ther. 1999 May; 6(5):715-28. PMID: 10505094.
      View in: PubMed
    63. Shinozaki K, Sato H, Iwakuma T, Sato R, Kurimoto T, Yoshida K. Synthesis and thromboxane A2 antagonistic activity activity of indane derivatives. Bioorg Med Chem Lett. 1999 Feb 08; 9(3):401-6. PMID: 10091692.
      View in: PubMed
    64. Tsuzuki T, Kawate H, Iwakuma T. [Study on carcinogenesis and mutation suppression: repair of alkylation DNA damage and suppression of tumors]. Fukuoka Igaku Zasshi. 1998 Jan; 89(1):1-10. PMID: 9494281.
      View in: PubMed
    65. Iwakuma T, Sakumi K, Nakatsuru Y, Kawate H, Igarashi H, Shiraishi A, Tsuzuki T, Ishikawa T, Sekiguchi M. High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase. Carcinogenesis. 1997 Aug; 18(8):1631-5. PMID: 9276640.
      View in: PubMed
    66. Tanaka K, Iwakuma T, Harimaya K, Sato H, Iwamoto Y. EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells. J Clin Invest. 1997 Jan 15; 99(2):239-47. PMID: 9005992.
      View in: PubMed
    Iwakuma's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description