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Last Name
Institution

Kate E. Kyler, MD, MSc, FAAP

TitlePhysician
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City MO 64108
ORCID ORCID Icon0000-0002-5631-2228 Additional info
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    Other Positions
    TitleAssistant Professor of Pediatrics
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics

    TitleEducation Assistant Professor of Pediatrics
    InstitutionUniversity of Kansas Medical Center
    DepartmentPediatrics


    Collapse Biography 
    Collapse education and training
    University of Nebraska Medical Center, Omaha NEMD2013Focus in Preventive Medicine
    McGaw Medical Center of Northwestern University/Ann & Robert H Lurie Children’s Hospital of Chicago, Chicago, ILInternship & Residency2016Pediatrics
    Children’s Mercy Kansas City, Kansas City, MOFellowship2019Pediatric Hospital Medicine
    University of Missouri-Kansas City, Kansas City, MOMSc2019Bioinformatics, Clinical Research
    Children's Mercy Kansas City, Kansas City, MOFellowship2024Pediatric Clinical Pharmacology

    Collapse Overview 

    Collapse Research 
    Collapse research overview
    Dr. Kyler is an Assistant Professor of Pediatrics, a clinician-researcher in the Division of Pediatric Hospital Medicine, and a Pediatric Clinical Pharmacologist at Children's Mercy Kansas City. Her research interests centers on how obesity affects outcomes and drug response for children with asthma and obesity, including investigations of disparities in clinical outcomes, drug dosing problems, drug pharmacokinetics/pharmacodynamics, and adverse events among this population of children. She has experience in health services and clinical research and has utilized varying large administrative and clinical datasets in her research. Her current work, supported by a Frontiers KL2 award, is investigating pharmacokinetic and pharmacodynamic differences for systemic corticosteroids in children with versus without obesity.
    Collapse research activities and funding
    Sarah Morrison Student Research Award     (Kathryn Kyler)Oct 1, 2018 - Sep 30, 2019
    University of Missouri-Kansas City School of Medicine
    Variation in medication dosing and guideline adherence by weight status for commonly prescribed medications during pediatric asthma hospitalizations
    Role Description: This investigation utilized a large, nationally representative retrospective database (Cerner Health Facts®) to examine rates of dosing guideline non-adherence in corticosteroids prescribed to hospitalized children with asthma based on weight status, with a special focus on children with obesity. We found that children with obesity are more likely to receive steroid doses that do not adhere to national dosing guidelines. These findings highlight the need for focused study of medications with high degrees of prescribing practice variation in children with obesity that could be putting this population of children at higher risk of adverse events.
    Role: PI
    Katharine Berry Richardson Foundation Award     (Kathryn Kyler)Oct 1, 2020 - Sep 30, 2022
    Children's Mercy Kansas City
    Adverse Event Trigger Rates in Hospitalized Children with Obesity
    Role Description: The goal of this study is to compare hospitalization adverse event trigger event rates between children with obesity and those without obesity.
    Role: Principal Investigator
    Ed Connolly Scholar Award     (Kathryn Kyler)Sep 30, 2023 - Sep 30, 2025
    Children's Mercy Kansas City
    Obesity’s Influence on Circulating Immune Cell Responses to Systemic Corticosteroids
    Role: PI
    KL2 TR002367     (Kyler)Jul 1, 2024 - Jun 30, 2026
    NCATS (via Frontiers CTSI)
    Obesity’s Influence on Systemic Corticosteroid Exposure and Response in Children with Asthma
    Role: PI

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Dunlap TC, Gonzalez D, Kyler KE, Helfer VE, Williams V, Friesen CS, Artz N, Chan S, Shakhnovich V. Evaluation of Obesity-Related Physiological Changes on Pantoprazole Clearance in Children Using a Population Pharmacokinetic Approach. J Clin Pharmacol. 2024 Aug 27. PMID: 39189986.
      View in: PubMed
    2. Clark NA, Kyler KE, Allen GL, Ausmus A, Berg K, Beyer J, Centanni R, Claeys C, Hall M, Miles A, Nyberg G, Malloy-Walton L. Variations in Alarm Burden, Source, and Cause Across Inpatient Units at a Children's Hospital. Hosp Pediatr. 2024 Aug 01; 14(8):642-648. PMID: 39011551.
      View in: PubMed
    3. Morales Junior R, Amajor V, Paice K, Kyler KE, Hambrick HR, Pavia KE, Haynes AS, Gooden F, Pais GM, Downes KJ, Ramsey LB, Wagner J, Tang Girdwood S. From Dose to Exposure: Shifting the Paradigm of Pediatric Clinical Pharmacology Research and Education. Clin Pharmacol Ther. 2024 Sep; 116(3):515-517. PMID: 38686743.
      View in: PubMed
    4. Kyler KE, Gaedigk A, Abdel-Rahman S, Staggs VS, Pearce RE, Toren P, Leeder JS, Shakhnovich V. Influence of novel CYP2C-haplotype on proton pump inhibitor pharmacokinetics in children. Clin Transl Sci. 2024 04; 17(4):e13782. PMID: 38629502.
      View in: PubMed
    5. Tang Girdwood S, Hall M, Antoon JW, Kyler KE, Williams DJ, Shah SS, Orth LE, Goldman J, Feinstein JA, Ramsey LB. Opportunities for Pharmacogenetic Testing to Guide Dosing of Medications in Youths With Medicaid. JAMA Netw Open. 2024 Feb 05; 7(2):e2355707. PMID: 38349656.
      View in: PubMed
    6. Kyler KE, Hall M, Antoon JW, Goldman J, Shah SS, Tang Girdwood S, Williams DJ, Feinstein JA. Major Drug-Drug Interaction Exposure Among Medicaid-Insured Children in the Outpatient Setting. Pediatrics. 2024 Jan 01; 153(2). PMID: 38174350.
      View in: PubMed
    7. Kyler KE, Szefler SJ. Fifty Years of Unraveling the Clinical Pharmacology of Corticosteroids. J Pharm Sci. 2024 Jan; 113(1):47-54. PMID: 37844761.
      View in: PubMed
    8. Kyler KE, Jones BL. The chicken or the egg: The role of IL-6 in pediatric obese and allergen-exposed asthma. J Allergy Clin Immunol. 2023 12; 152(6):1420-1422. PMID: 37806322.
      View in: PubMed
    9. Antoon JW, Feinstein JA, Goldman JL, Kyler KE, Shah SS. Advancing pediatric medication safety using real-world data: Current problems and potential solutions. J Hosp Med. 2023 09; 18(9):865-869. PMID: 36855275.
      View in: PubMed
    10. Antoon JW, Hall M, Feinstein JA, Kyler KE, Shah SS, Girdwood ST, Goldman JL, Grijalva CG, Williams DJ. Guideline-Concordant Antiviral Treatment in Children at High Risk for Influenza Complications. Clin Infect Dis. 2023 02 08; 76(3):e1040-e1046. PMID: 35867691.
      View in: PubMed
    11. Kyler KE, Hall M, Antoon JW, Goldman J, Grijalva CG, Shah SS, Tang Girdwood S, Williams DJ, Feinstein JA. Polypharmacy among medicaid-insured children with and without documented obesity. Pharmacotherapy. 2023 07; 43(7):588-595. PMID: 36564960.
      View in: PubMed
    12. Kyler KE, Houtrow A, Hall M. Prevalence and Severity of Chronic Conditions Among Adolescents With Obesity. Child Obes. 2024 01; 20(1):68-71. PMID: 36594991.
      View in: PubMed
    13. Morrison JM, Cotter JM, Jenkins AM, Kyler KE, Girdwood SCT. Fostering sustainable interinstitutional peer mentorship groups to support professional goals in hospital medicine. J Hosp Med. 2023 08; 18(8):761-764. PMID: 36583263.
      View in: PubMed
    14. Kyler KE, Hall M, Bettenhausen JL, Clark NA, Hampl S, Davis AM. Medicaid Expenditures among Children with Documented Obesity. Child Obes. 2023 04; 19(3):160-168. PMID: 35666560.
      View in: PubMed
    15. Kyler KE, Lee BR, Glynn EF, Waddell JP, Hoffman MA, Goldman JL. Clinical Outcome and Antibiotic Dosing Differences by Weight in Children With Acute Osteomyelitis. Hosp Pediatr. 2021 10; 11(10):1112-1120. PMID: 34593567.
      View in: PubMed
    16. Kyler KE, Shipp C, Schuler CL. Obesity in asthma: Intricately linked and often overlooked. Ann Allergy Asthma Immunol. 2021 11; 127(5):589-590. PMID: 34363972.
      View in: PubMed
    17. Kyler KE, Hall M, Halvorson EE, Davis AM. Associations between Obesity and Adverse Childhood Experiences in the United States. Child Obes. 2021 07; 17(5):342-348. PMID: 33877887.
      View in: PubMed
    18. Kyler KE, Bettenhausen JL, Hall M, Glynn EF, Hoffman MA, Shakhnovich V, Smolderen K, Davis AM. Obesity and Corticosteroid Dosing Guideline Adherence in Children Hospitalized With Asthma. Hosp Pediatr. 2021 04; 11(4):380-388. PMID: 33664119.
      View in: PubMed
    19. Kyler KE, Hall M, Bettenhausen JL. Associations Between Obesity and Use for Pediatric Hospitalizations. Hosp Pediatr. 2020 11; 10(11):997-1001. PMID: 33097566.
      View in: PubMed
    20. Shakhnovich V, Kyler KE. Filling the Gap in Knowledge for Drug Dose Individualization in Pediatric Obesity. Obesity (Silver Spring). 2020 06; 28(6):1003. PMID: 32441475.
      View in: PubMed
    21. Synhorst DC, Johnson MB, Bettenhausen JL, Kyler KE, Richardson TE, Mann KJ, Fieldston ES, Hall M. Room Costs for Common Pediatric Hospitalizations and Cost-Reducing Quality Initiatives. Pediatrics. 2020 06; 145(6). PMID: 32366609.
      View in: PubMed
    22. Masonbrink A, Richardson T, Catley D, Miller MK, Hall M, Kyler KE, Daly A, Synhorst D, Connelly M. Opioid Use to Treat Migraine Headaches in Hospitalized Children and Adolescents. Hosp Pediatr. 2020 05; 10(5):401-407. PMID: 32295812.
      View in: PubMed
    23. Tang Girdwood SC, Chen JK, Kyler KE, Morrison JM. Expanding journal clubs beyond single institutions using Twitter. Med Educ. 2019 11; 53(11):1151. PMID: 31650613.
      View in: PubMed
    24. Kyler KE, Bettenhausen JL, Hall M, Hampl S. Prevalence and Trends in Obesity Among Hospitalized Children. Hosp Pediatr. 2019 11; 9(11):897-902. PMID: 31645359.
      View in: PubMed
    25. Kyler KE, Wagner J, Hosey-Cojocari C, Watt K, Shakhnovich V. Drug Dose Selection in Pediatric Obesity: Available Information for the Most Commonly Prescribed Drugs to Children. Paediatr Drugs. 2019 Oct; 21(5):357-369. PMID: 31432433.
      View in: PubMed
    26. Kyler KE, Bettenhausen JL, Hall M, Fraser JD, Sweeney B. Trends in Volume and Utilization Outcomes in Adolescent Metabolic and Bariatric Surgery at Children's Hospitals. J Adolesc Health. 2019 09; 65(3):331-336. PMID: 31196785.
      View in: PubMed
    27. Puls HT, Bettenhausen JL, Markham JL, Walker JM, Drake B, Kyler KE, Queen MA, Hall M. Urban-Rural Residence and Child Physical Abuse Hospitalizations: A National Incidence Study. J Pediatr. 2019 02; 205:230-235.e2. PMID: 30392871.
      View in: PubMed
    28. Kyler KE, Kadakia RB, Palac HL, Kwon S, Ariza AJ, Binns HJ. Use of Metformin for Weight Management in Children and Adolescents With Obesity in the Clinical Setting. Clin Pediatr (Phila). 2018 12; 57(14):1677-1685. PMID: 30261744.
      View in: PubMed
    29. Kyler KE, McCulloh RJ. Current Concepts in the Evaluation and Management of Bronchiolitis. Infect Dis Clin North Am. 2018 03; 32(1):35-45. PMID: 29269190.
      View in: PubMed
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