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Last Name
Institution

Midhat Farooqi, MD, PhD

TitleDirector, Molecular Oncology, Center for Pediatric Genomic Medicine
InstitutionChildren's Mercy Kansas City
DepartmentPathology and Laboratory Medicine
Address2401 Gillham Rd
Kansas City MO 64108
ORCID ORCID Icon0000-0002-5238-1349 Additional info
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    Other Positions
    TitleClinical Assistant Professor
    InstitutionUniversity of Kansas Medical Center
    DepartmentPathology and Laboratory Medicine

    TitleAssistant Professor
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPathology and Laboratory Medicine


    Collapse Biography 
    Collapse education and training
    University of Texas Southwestern Medical Center, Dallas, TXMD, PhD2012Molecular Genetics
    Hospital of the University of Pennsylvania, Philadelphia, PAResidency2013Anatomic & Clinical Pathology
    University of Texas Southwestern Medical Center, Dallas, TXResidency2015Clinical Pathology
    Hospital of the University of Pennsylvania, Philadelphia, PAFellowship2016Molecular Genetic Pathology

    Collapse Overview 

    Collapse Research 
    Collapse research overview
    As a molecular pathologist, Dr. Farooqi interprets clinical genetic testing results for both pediatric and adult patients in the setting of inherited disease and oncology, including whole exome sequencing and tumor somatic profiling. His clinical interests involve the development of new clinical diagnostic tests, especially for pediatric oncology. His research interests include epigenetic profiling and single cell sequencing of pediatric liquid and solid tumors. Dr. Farooqi works closely with Dr. Erin Guest and other researchers at the Center for Pediatric Genomic Medicine. The CPGM researchers have extensive experience in all aspects of sequencing and have supported two clinical trials studying leukemia in children and infants—T2016-003 and AALL0631—by performing and analyzing whole genome, whole exome, bulk RNA, whole genome bisulfite, and single cell sequencing of patient samples in collaboration with Johns Hopkins University. The research team will be performing similar work for two current trials: AALL15P1 (studying infant leukemia) and NCT02789228 (studying multi-antigen specific lymphocytes for the treatment of pediatric solid tumors); Dr. Farooqi is the Principal Investigator for the sequencing project supporting NCT02789228 and looks forward to additional collaborative sequencing projects, especially in the areas of pediatric oncology and cancer immunotherapy.
    Collapse research activities and funding
         (Midhat Farooqi)Dec 1, 2019 - Nov 30, 2022
    Braden’s Hope For Childhood Cancer
    Targeting Solid Tumors with Multi-antigen Specific T cells by Identifying the Genetic and Epigenetic Determinants of Therapeutic Response
    Role: Principal Investigator

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Burke MJ, Kostadinov R, Sposto R, Gore L, Kelley SM, Rabik C, Trepel JB, Lee MJ, Yuno A, Lee S, Bhojwani D, Jeha S, Chang BH, Sulis ML, Hermiston ML, Gaynon P, Huynh V, Verma A, Gardner R, Heym KM, Dennis RM, Ziegler DS, Laetsch TW, Oesterheld JE, Dubois SG, Pollard JA, Glade-Bender J, Cooper TM, Kaplan JA, Farooqi MS, Yoo B, Guest E, Wayne AS, Brown PA. Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study. Clin Cancer Res. 2020 Jan 22. PMID: 31969338.
      View in: PubMed
    2. Porath B, Farooki S, Gener M, Amudhavalli SM, Grote L, Cooley LD, Ginn K, Farooqi MS. Occurrence and characterization of medulloblastoma in a patient with Curry-Jones syndrome. Clin Genet. 2020 Apr; 97(4):670-671. PMID: 31825089.
      View in: PubMed
    3. Ahmed AA, Vundamati D, Farooqi M, Repnikova E, Zinkus T, Hetherington M, Paulson L. Next-Generation Sequencing in the Diagnosis of Rare Pediatric Sinonasal Tumors. Ear Nose Throat J. 2019 Sep 24; 145561319863371. PMID: 31550935.
      View in: PubMed
    4. Repnikova E, Roberts J, Mc Dermott S, Farooqi MS, Iqbal NT, Silvey M, Nolen J, Taboada E, Li W. Clinical and molecular characterization of novel deletions causing epsilon gamma delta beta thalassemia: Report of two cases. Pathol Res Pract. 2019 Oct; 215(10):152578. PMID: 31451289.
      View in: PubMed
    5. Ahmed IA, Farooqi MS, Vander Lugt MT, Boklan J, Rose M, Friehling ED, Triplett B, Lieuw K, Saldana BD, Smith CM, Schwartz JR, Goyal RK. Outcomes of Hematopoietic Cell Transplantation in Patients with Germline SAMD9/SAMD9L Mutations. Biol Blood Marrow Transplant. 2019 11; 25(11):2186-2196. PMID: 31306780.
      View in: PubMed
    6. Li W, Cooley LD, August KJ, Richardson AI, Shao L, Ahmed AA, Farooqi MS, Zwick DL. Cuplike nuclear morphology is highly associated with IKZF1 deletion in pediatric precursor B-cell ALL. Blood. 2019 07 18; 134(3):324-329. PMID: 31076445.
      View in: PubMed
    7. Ahmed AA, Vundamati DS, Farooqi MS, Guest E. Precision Medicine in Pediatric Cancer: Current Applications and Future Prospects. High Throughput. 2018 Dec 13; 7(4). PMID: 30551569.
      View in: PubMed
    8. Sussman RT, Shaffer S, Azzato EM, DeSloover D, Farooqi MS, Meyer A, Lieberman DB, Bigdeli A, Paolillo C, Ganapathy K, Sukhadia S, Rosenbaum JN, Daber RD, Morrissette JJD. Validation of a next-generation sequencing oncology panel optimized for low input DNA. Cancer Genet. 2018 12; 228-229:55-63. PMID: 30553474.
      View in: PubMed
    9. Rea B, Haun P, Emerson R, Vignali M, Farooqi M, Samimi S, Elenitsas R, Kirsch I, Bagg A. Role of high-throughput sequencing in the diagnosis of cutaneous T-cell lymphoma. J Clin Pathol. 2018 Sep; 71(9):814-820. PMID: 29636372.
      View in: PubMed
    10. Gentile C, Van Deerlin VM, Goldberg DS, Reese PP, Hasz RD, Abt P, Blumberg E, Farooqi MS. Hepatitis C virus genotyping of organ donor samples to aid in transplantation of HCV-positive organs. Clin Transplant. 2018 02; 32(2). PMID: 29220079.
      View in: PubMed
    11. Goldberg DS, Abt PL, Blumberg EA, Van Deerlin VM, Levine M, Reddy KR, Bloom RD, Nazarian SM, Sawinski D, Porrett P, Naji A, Hasz R, Suplee L, Trofe-Clark J, Sicilia A, McCauley M, Farooqi M, Gentile C, Smith J, Reese PP. Trial of Transplantation of HCV-Infected Kidneys into Uninfected Recipients. N Engl J Med. 2017 06 15; 376(24):2394-2395. PMID: 28459186.
      View in: PubMed
    12. Farooqi MS, Mitui M, Londin ER, Park JY. High Concentration Capture Probes Enhance Massively Parallel Sequencing Assays. Clin Chem. 2016 07; 62(7):1032-4. PMID: 27217445.
      View in: PubMed
    13. Davies KD, Farooqi MS, Gruidl M, Hill CE, Woolworth-Hirschhorn J, Jones H, Jones KL, Magliocco A, Mitui M, O'Neill PH, O'Rourke R, Patel NM, Qin D, Ramos E, Rossi MR, Schneider TM, Smith GH, Zhang L, Park JY, Aisner DL. Multi-Institutional FASTQ File Exchange as a Means of Proficiency Testing for Next-Generation Sequencing Bioinformatics and Variant Interpretation. J Mol Diagn. 2016 07; 18(4):572-9. PMID: 27155050.
      View in: PubMed
    14. Farooqi MS, Hashim IA. A woman with primary biliary cirrhosis and hyponatremia. Clin Chem. 2015 Aug; 61(8):1028-31. PMID: 26220582.
      View in: PubMed
    15. Farooqi MS, Lai Y, Lancaster E, Schmitt SE, Sachais BS. Therapeutic plasma exchange and immunosuppressive therapy in a patient with anti-GAD antibody-related epilepsy: quantification of the antibody response. J Clin Apher. 2015 Feb; 30(1):8-14. PMID: 24961613.
      View in: PubMed
    16. Owen JL, Zhang Y, Bae SH, Farooqi MS, Liang G, Hammer RE, Goldstein JL, Brown MS. Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16184-9. PMID: 22927400.
      View in: PubMed
    17. Evers BM, Farooqi MS, Shelton JM, Richardson JA, Goldstein JL, Brown MS, Liang G. Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin. J Invest Dermatol. 2010 May; 130(5):1237-48. PMID: 20090767.
      View in: PubMed
    18. Schneider JW, Gao Z, Li S, Farooqi M, Tang TS, Bezprozvanny I, Frantz DE, Hsieh J. Small-molecule activation of neuronal cell fate. Nat Chem Biol. 2008 Jul; 4(7):408-10. PMID: 18552832.
      View in: PubMed
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