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J. Steven Leeder, PharmD, PhD

TitleDeputy Director, Children's Research Institute
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City MO 64108
ORCID ORCID Icon0000-0001-6688-0504 Additional info
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    Other Positions
    TitleAssociate Chair-Research
    InstitutionChildren's Mercy Kansas City
    DepartmentPediatrics

    TitleMarion Merrell Dow Endowed Chair in Pediatric Precision Therapeutics
    InstitutionChildren's Mercy Kansas City
    DepartmentChildren's Research Insitute

    TitleClinical Professor
    InstitutionUniversity of Kansas Medical Center
    DepartmentPediatrics

    TitleProfessor
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics and Pharmacology

    TitleAdjunct Professor
    InstitutionUniversity of Kansas Medical Center
    DepartmentPharmacology, Toxicology and Therapeutics

    TitleAdjunct Professor
    InstitutionUniversity of Kansas
    DepartmentPharmaceutical Chemistry

    TitleAdjunct Professor
    InstitutionUniversity of Utah
    DepartmentPediatrics


    Collapse Biography 
    Collapse education and training
    University of Minnesota, Minneapolis, MNPharmD1982
    University of Toronto, Toronto, Ontario, CanadaPhD1989
    The Hospital for Sick Children, Toronto, Ontario, Canada Fellowship1989Clinical Pharmacology
    Collapse awards and honors
    2019Rawls-Palmer Progress in Medicine Award, American Society for Clinical Pharmacology and Therapeutics
    2019Ingram’s 2019 Heroes in Healthcare
    2008Ninth Annual Charlotte Promersberger-Johnston Lectureship, Children’s Hospital of Wisconsin, Milwaukee, WI

    Collapse Overview 

    Collapse Research 
    Collapse research overview
    In his former role as Director of the Division of Clinical Pharmacology and Therapeutic Innovation and Associate Chair-Research, Department of Pediatrics at Children’s Mercy Dr. Leeder led a program consisting of multidisciplinary teams of researchers with expertise in analytical chemistry, drug biotransformation, gene regulation, pharmacogenomics, and pharmacokinetics to investigate variability in medication response in children. An important component of the program was to provide an environment in which trainees and early career faculty members from diverse backgrounds could develop as independent investigators in their areas of research interest. These research interests generally are closely aligned with their clinical expertise with the goal of implementing precision therapeutics in their clinical subspecialties to benefit the patients they serve.

    The Pediatric Precision Therapeutics Area of Interest in the Children’s Research Institute complements the Clinical Pharmacology program at Children’s Mercy, the largest in North America. The Precision Therapeutics program extends the Clinical Pharmacology emphasis on developing individuals to a more institutional level by providing support to pediatric subspecialties interested in adding precision therapeutics to their portfolio of research programs. In this way the program serves as a model of integrated research that will extend throughout the Children’s Research Institute.

    Dr. Leeder’s research focuses on characterization of the relative contributions of ontogeny, genetic variation and disease to observed variability in drug disposition and response in children. Over the years, these research activities have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids with current funding as one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development.
    Collapse research activities and funding
    T32HD069038     (ABDEL-RAHMAN, SUSAN M)May 1, 2011 - Apr 30, 2021
    NIH/NICHD
    Children's Mercy Hospital Collaborative Fellowship Program in Pediatric Pharmacology
    Role: Co-Investigator, Senior Mentor

    R01HD081299     (PRASAD, BHAGWAT)Apr 1, 2015 - Feb 29, 2020
    NIH
    PBPK prediction of ontogeny mediated alteration in hepatic drug elimination
    Role: Co-Investigator

    U54HD090258     (LEEDER, JAMES STEVEN)Sep 23, 2016 - Jun 30, 2021
    NIH
    Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids
    Role: Principal Investigator

    KL2TR002367     (WAGNER)Sep 1, 2017 - Dec 31, 2019
    NIH/NCRR
    Clinical and Translational Mentored Career Development Award
    Role: Primary Mentor

    TL1TR002368     (CHOI, WON S.)Sep 7, 2017 - Jun 30, 2022
    NIH
    Frontiers: University of Kansas Clinical and Translational Science Institute
    Role: Co-Investigator

    UL1 RR 033179-07     (BAROHN)Sep 7, 2017 - Jun 30, 2022
    NIH/NCRR
    Frontiers: The Heartland Institute for Clinical and Translational Research
    Role: Sub-contract PI; Co-Director

    R01GM129783     (GOLDMAN, JENNIFER LYNN)Aug 1, 2018 - Jun 30, 2023
    NIH
    Trimethoprim: an overlooked contributor of trimethoprim-sulfamethoxazole idiosyncratic adverse drug reactions
    Role: Co-Investigator

    K23HD091362     (LEWIS, TAMORAH R.)Sep 25, 2018 - Aug 31, 2022
    NIH
    Ontogeny and Genetics of NSAID Dose-Exposure Relationship in Preterm Infants
    Role: Co-Investigator

    R13TR003029     (LEEDER, JAMES STEVEN)Jul 15, 2019 - Jul 14, 2020
    NIH
    2019 Drug Metabolism Gordon Research Conference Guiding Drug Development Using Translational ADME Science
    Role: Principal Investigator

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. van Groen BD, Bi C, Gaedigk R, Staggs VS, Tibboel D, de Wildt SN, Leeder JS. Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver. Clin Transl Sci. 2020 Jan 09. PMID: 31917523.
      View in: PubMed
    2. Zhang H, Basit A, Wolford C, Chen KF, Gaedigk A, Lin YS, Leeder JS, Prasad B. Normalized testosterone glucuronide (TG/AG) as a potential urinary biomarker for highly variable UGT2B17 in children 7 to 18 years. Clin Pharmacol Ther. 2020 Jan 03. PMID: 31900930.
      View in: PubMed
    3. Hicks JK, Bishop JR, Gammal RS, Sangkuhl K, Bousman CA, Leeder JS, Llerena A, Mueller DJ, Ramsey LB, Scott SA, Skaar TC, Caudle KE, Klein TE, Gaedigk A. A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy. Clin Pharmacol Ther. 2020 Jan; 107(1):50-52. PMID: 31664715.
      View in: PubMed
    4. Maulik D, van Haandel L, Allsworth J, Chaisanguanthum KS, Yeast JD, Leeder JS. The effect of race and supplementation on maternal and umbilical cord plasma folates. J Matern Fetal Neonatal Med. 2019 Oct 21; 1-9. PMID: 31630592.
      View in: PubMed
    5. Leeder JS. Who Believes They Are "Just Average": Informing the Treatment of Individual Patients Using Population Data. Clin Pharmacol Ther. 2019 Nov; 106(5):939-941. PMID: 31509232.
      View in: PubMed
    6. Li CY, Hosey-Cojocari C, Basit A, Unadkat JD, Leeder JS, Prasad B. Optimized Renal Transporter Quantification by Using Aquaporin 1 and Aquaporin 2 as Anatomical Markers: Application in Characterizing the Ontogeny of Renal Transporters and Its Correlation with Hepatic Transporters in Paired Human Samples. AAPS J. 2019 07 11; 21(5):88. PMID: 31297641.
      View in: PubMed
    7. Ogungbenro K, Wagner JB, Abdel-Rahman S, Leeder JS, Galetin A. A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents. Eur J Clin Pharmacol. 2019 Sep; 75(9):1227-1235. PMID: 31172248.
      View in: PubMed
    8. Ladumor MK, Bhatt DK, Gaedigk A, Sharma S, Thakur A, Pearce RE, Leeder JS, Bolger MB, Singh S, Prasad B. Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism. Drug Metab Dispos. 2019 08; 47(8):818-831. PMID: 31101678.
      View in: PubMed
    9. Brown JT, Bishop JR, Sangkuhl K, Nurmi EL, Mueller DJ, Dinh JC, Gaedigk A, Klein TE, Caudle KE, McCracken JT, de Leon J, Leeder JS. Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy. Clin Pharmacol Ther. 2019 Jul; 106(1):94-102. PMID: 30801677.
      View in: PubMed
    10. Beck JN, Suppes SL, Smith CR, Lee BR, Leeder JS, VanDoren M, Newland JG, Goldman JL. Cost and Potential Avoidability of Antibiotic-Associated Adverse Drug Reactions in Children. J Pediatric Infect Dis Soc. 2019 Mar 28; 8(1):66-68. PMID: 29165624.
      View in: PubMed
    11. Stancil SL, Pearce RE, Tyndale RF, Kearns GL, Vyhlidal CA, Leeder JS, Abdel-Rahman S. Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults. Br J Clin Pharmacol. 2019 05; 85(5):960-969. PMID: 30706508.
      View in: PubMed
    12. Wagner JB, Abdel-Rahman S, Gaedigk R, Gaedigk A, Raghuveer G, Staggs VS, Kauffman R, Van Haandel L, Leeder JS. Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia. Clin Pharmacol Ther. 2019 Jun; 105(6):1501-1512. PMID: 30549267.
      View in: PubMed
    13. McLaughlin MJ, Wagner J, Shahknovich V, Carleton B, Leeder JS. Considerations for Implementing Precision Therapeutics for Children. Clin Transl Sci. 2019 03; 12(2):140-150. PMID: 30516322.
      View in: PubMed
    14. McLaughlin MJ, Abdel-Rahman S, Leeder JS. Examining the role of precision medicine with oral baclofen in pediatric patients with cerebral palsy. Curr Phys Med Rehabil Rep. 2019 Mar; 7(1):40-45. PMID: 31579558.
      View in: PubMed
    15. McLaughlin MJ, Abdel-Rahman SM, Leeder JS. Examining the role of precision medicine with oral baclofen in pediatric patients with cerebral palsy. Curr Phys Med Rehab Rep. 2019.
    16. Lewis T, Leeder JS. Pharmacogenomics and implementation of precision therapeutics in the neonatal ICU: a new frontier? Pharmacogenomics. 2018 11; 19(16):1231-1233. PMID: 30334480.
      View in: PubMed
    17. Shakhnovich V, Abdel-Rahman S, Friesen CA, Weigel J, Pearce RE, Gaedigk A, Leeder JS, Kearns GL. Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity. Pediatr Obes. 2019 01; 14(1). PMID: 30257076.
      View in: PubMed
    18. van Groen BD, van de Steeg E, Mooij MG, van Lipzig MMH, de Koning BAE, Verdijk RM, Wortelboer HM, Gaedigk R, Bi C, Leeder JS, van Schaik RHN, van Rosmalen J, Tibboel D, Vaes WH, de Wildt SN. Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants. Eur J Pharm Sci. 2018 Nov 01; 124:217-227. PMID: 30171984.
      View in: PubMed
    19. Bhatt DK, Mehrotra A, Gaedigk A, Chapa R, Basit A, Zhang H, Choudhari P, Boberg M, Pearce RE, Gaedigk R, Broeckel U, Leeder JS, Prasad B. Age- and Genotype-Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate-Glucuronosyltransferases in Human Liver. Clin Pharmacol Ther. 2019 01; 105(1):131-141. PMID: 29737521.
      View in: PubMed
    20. Lewis T, Van Haandel L, Scott A, Leeder JS. Intensive and prolonged urine collection in preterm infants reveals three distinct indomethacin metabolic patterns: potential implications for drug dosing. Pediatr Res. 2018 09; 84(3):325-327. PMID: 29967531.
      View in: PubMed
    21. Zhang LQ, Nsumu M, Huang P, Heruth DP, Riordan SM, Shortt K, Zhang N, Grigoryev DN, Li DY, Friesen CA, Van Haandel L, Leeder JS, Olson J, Ye SQ. Novel Protective Role of Nicotinamide Phosphoribosyltransferase in Acetaminophen-Induced Acute Liver Injury in Mice. Am J Pathol. 2018 07; 188(7):1640-1652. PMID: 29684358.
      View in: PubMed
    22. Gaedigk A, Dinh JC, Jeong H, Prasad B, Leeder JS. Ten Years' Experience with the CYP2D6 Activity Score: A Perspective on Future Investigations to Improve Clinical Predictions for Precision Therapeutics. J Pers Med. 2018 Apr 17; 8(2). PMID: 29673183.
      View in: PubMed
    23. Huddart R, Leeder JS, Altman RB, Klein TE. PharmGKB summary: clobazam pathway, pharmacokinetics. Pharmacogenet Genomics. 2018 04; 28(4):110-115. PMID: 29517622.
      View in: PubMed
    24. Volpi S, Bult CJ, Chisholm RL, Deverka PA, Ginsburg GS, Jacob HJ, Kasapi M, McLeod HL, Roden DM, Williams MS, Green ED, Rodriguez LL, Aronson S, Cavallari LH, Denny JC, Dressler LG, Johnson JA, Klein TE, Leeder JS, Piquette-Miller M, Perera M, Rasmussen-Torvik LJ, Rehm HL, Ritchie MD, Skaar TC, Wagle N, Weinshilboum R, Weitzel KW, Wildin R, Wilson J, Manolio TA, Relling MV. Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects. Clin Pharmacol Ther. 2018 05; 103(5):778-786. PMID: 29460415.
      View in: PubMed
    25. Bhatt DK, Basit A, Zhang H, Gaedigk A, Lee SB, Claw KG, Mehrotra A, Chaudhry AS, Pearce RE, Gaedigk R, Broeckel U, Thornton TA, Nickerson DA, Schuetz EG, Amory JK, Leeder JS, Prasad B. Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex. Drug Metab Dispos. 2018 06; 46(6):888-896. PMID: 29602798.
      View in: PubMed
    26. Meier R, Bi C, Gaedigk R, Heruth DP, Ye SQ, Leeder JS, Fridley BL. Ontogeny-related pharmacogene changes in the pediatric liver transcriptome. Pharmacogenet Genomics. 2018 03; 28(3):86-94. PMID: 29360682.
      View in: PubMed
    27. Wagner JB, Abdel-Rahman S, Van Haandel L, Gaedigk A, Gaedigk R, Raghuveer G, Kauffman R, Leeder JS. Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics. J Clin Pharmacol. 2018 06; 58(6):823-833. PMID: 29469964.
      View in: PubMed
    28. Petrikin JE, Cakici JA, Clark MM, Willig LK, Sweeney NM, Farrow EG, Saunders CJ, Thiffault I, Miller NA, Zellmer L, Herd SM, Holmes AM, Batalov S, Veeraraghavan N, Smith LD, Dimmock DP, Leeder JS, Kingsmore SF. The NSIGHT1-randomized controlled trial: rapid whole-genome sequencing for accelerated etiologic diagnosis in critically ill infants. NPJ Genom Med. 2018; 3:6. PMID: 29449963.
      View in: PubMed
    29. Singh RK, van Haandel L, Heruth DP, Ye SQ, Leeder JS, Becker ML, Funk RS. Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP. J Pharmacol Exp Ther. 2018 04; 365(1):96-106. PMID: 29420256.
      View in: PubMed
    30. Patel P, Leeder JS, Piquette-Miller M, Dupuis LL. Response to 'Aprepitant and fosaprepitant decrease the effectiveness of hormonal contraceptives'. Br J Clin Pharmacol. 2018 03; 84(3):604. PMID: 29315725.
      View in: PubMed
    31. Gaedigk A, Ingelman-Sundberg M, Miller NA, Leeder JS, Whirl-Carrillo M, Klein TE. The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database. Clin Pharmacol Ther. 2018 03; 103(3):399-401. PMID: 29134625.
      View in: PubMed
    32. Manolio TA, Hutter CM, Avigan M, Cibotti R, Davis RL, Denny JC, Grenade L, Wheatley LM, Carrington MN, Chantratita W, Chung WH, Dalton AD, Hung SI, Lee MTM, Leeder JS, Lertora JJL, Mahasirimongkol S, McLeod HL, Mockenhaupt M, Pacanowski M, Phillips EJ, Pinheiro S, Pirmohamed M, Sung C, Suwankesawong W, Trepanier L, Tumminia SJ, Veenstra D, Yuliwulandari R, Shear NH. Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis. Clin Pharmacol Ther. 2018 03; 103(3):390-394. PMID: 29105735.
      View in: PubMed
    33. Mirzakhani H, De Vivo I, Leeder JS, Gaedigk R, Vyhlidal CA, Weiss ST, Tantisira K. Early pregnancy intrauterine fetal exposure to maternal smoking and impact on fetal telomere length. Eur J Obstet Gynecol Reprod Biol. 2017 Nov; 218:27-32. PMID: 28926727.
      View in: PubMed
    34. McLaughlin MJ, He Y, Brunstrom-Hernandez J, Thio LL, Carleton BC, Ross CJD, Gaedigk A, Lewandowski A, Dai H, Jusko WJ, Leeder JS. Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy. PM R. 2018 03; 10(3):235-243. PMID: 28867665.
      View in: PubMed
    35. Xu M, Bhatt DK, Yeung CK, Claw KG, Chaudhry AS, Gaedigk A, Pearce RE, Broeckel U, Gaedigk R, Nickerson DA, Schuetz E, Rettie AE, Leeder JS, Thummel KE, Prasad B. Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver. J Pharmacol Exp Ther. 2017 11; 363(2):265-274. PMID: 28819071.
      View in: PubMed
    36. Bhatt DK, Gaedigk A, Pearce RE, Leeder JS, Prasad B. Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver. Drug Metab Dispos. 2017 09; 45(9):1044-1048. PMID: 28607029.
      View in: PubMed
    37. Patel P, Leeder JS, Piquette-Miller M, Dupuis LL. Aprepitant and fosaprepitant drug interactions: a systematic review. Br J Clin Pharmacol. 2017 Oct; 83(10):2148-2162. PMID: 28470980.
      View in: PubMed
    38. Darwich AS, Ogungbenro K, Vinks AA, Powell JR, Reny JL, Marsousi N, Daali Y, Fairman D, Cook J, Lesko LJ, McCune JS, Knibbe C, de Wildt SN, Leeder JS, Neely M, Zuppa AF, Vicini P, Aarons L, Johnson TN, Boiani J, Rostami-Hodjegan A. Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future. Clin Pharmacol Ther. 2017 May; 101(5):646-656. PMID: 28182269.
      View in: PubMed
    39. Zhang LQ, Van Haandel L, Xiong M, Huang P, Heruth DP, Bi C, Gaedigk R, Jiang X, Li DY, Wyckoff G, Grigoryev DN, Gao L, Li L, Wu M, Leeder JS, Ye SQ. Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase. Cell Death Dis. 2017 03 23; 8(3):e2705. PMID: 28333140.
      View in: PubMed
    40. Berg JS, Agrawal PB, Bailey DB, Beggs AH, Brenner SE, Brower AM, Cakici JA, Ceyhan-Birsoy O, Chan K, Chen F, Currier RJ, Dukhovny D, Green RC, Harris-Wai J, Holm IA, Iglesias B, Joseph G, Kingsmore SF, Koenig BA, Kwok PY, Lantos J, Leeder SJ, Lewis MA, McGuire AL, Milko LV, Mooney SD, Parad RB, Pereira S, Petrikin J, Powell BC, Powell CM, Puck JM, Rehm HL, Risch N, Roche M, Shieh JT, Veeraraghavan N, Watson MS, Willig L, Yu TW, Urv T, Wise AL. Newborn Sequencing in Genomic Medicine and Public Health. Pediatrics. 2017 Feb; 139(2). PMID: 28096516.
      View in: PubMed
    41. Twist GP, Gaedigk A, Miller NA, Farrow EG, Willig LK, Dinwiddie DL, Petrikin JE, Soden SE, Herd S, Gibson M, Cakici JA, Riffel AK, Leeder JS, Dinakarpandian D, Kingsmore SF. Erratum: Constellation: a tool for rapid, automated phenotype assignment of a highly polymorphic pharmacogene, CYP2D6, from whole-genome sequences. NPJ Genom Med. 2017; 2:16039. PMID: 29266105.
      View in: PubMed
    42. Boberg M, Vrana M, Mehrotra A, Pearce RE, Gaedigk A, Bhatt DK, Leeder JS, Prasad B. Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants. Drug Metab Dispos. 2017 02; 45(2):216-223. PMID: 27895113.
      View in: PubMed
    43. Wang LA, Gonzalez D, Leeder JS, Tyndale RF, Pearce RE, Benjamin DK, Kearns GL, Cohen-Wolkowiez M. Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation. J Clin Pharmacol. 2017 02; 57(2):230-234. PMID: 27417511.
      View in: PubMed
    44. Prasad B, Gaedigk A, Vrana M, Gaedigk R, Leeder JS, Salphati L, Chu X, Xiao G, Hop C, Evers R, Gan L, Unadkat JD. Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics. Clin Pharmacol Ther. 2016 10; 100(4):362-70. PMID: 27301780.
      View in: PubMed
    45. Goldman JL, Koen YM, Rogers SA, Li K, Leeder JS, Hanzlik RP. Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes. Drug Metab Dispos. 2016 10; 44(10):1603-7. PMID: 27457783.
      View in: PubMed
    46. Gaedigk A, Sangkuhl K, Whirl-Carrillo M, Klein T, Leeder JS. Prediction of CYP2D6 phenotype from genotype across world populations. Genet Med. 2017 01; 19(1):69-76. PMID: 27388693.
      View in: PubMed
    47. Leeder JS, Meibohm B. Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development. Drug Metab Dispos. 2016 07; 44(7):916-23. PMID: 27302933.
      View in: PubMed
    48. Kho AT, Chhabra D, Sharma S, Qiu W, Carey VJ, Gaedigk R, Vyhlidal CA, Leeder JS, Tantisira KG, Weiss ST. Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome. Am J Respir Cell Mol Biol. 2016 06; 54(6):814-21. PMID: 26584061.
      View in: PubMed
    49. Funk RS, Singh R, Pramann L, Gigliotti N, Islam S, Heruth DP, Ye SQ, Chan MA, Leeder JS, Becker ML. Nicotinamide Phosphoribosyltransferase Attenuates Methotrexate Response in Juvenile Idiopathic Arthritis and In Vitro. Clin Transl Sci. 2016 06; 9(3):149-57. PMID: 27166432.
      View in: PubMed
    50. Dinh JC, Pearce RE, Van Haandel L, Gaedigk A, Leeder JS. Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children. Drug Metab Dispos. 2016 07; 44(7):1070-9. PMID: 27052878.
      View in: PubMed
    51. Abdel-Rahman SM, Breitkreutz ML, Bi C, Matzuka BJ, Dalal J, Casey KL, Garg U, Winkle S, Leeder JS, Breedlove J, Rivera B. Design and Testing of an EHR-Integrated, Busulfan Pharmacokinetic Decision Support Tool for the Point-of-Care Clinician. Front Pharmacol. 2016; 7:65. PMID: 27065859.
      View in: PubMed
    52. Shakhnovich V, Vyhlidal C, Friesen C, Hildreth A, Singh V, Daniel J, Kearns GL, Leeder JS. Decreased Pregnane X Receptor Expression in Children with Active Crohn's Disease. Drug Metab Dispos. 2016 07; 44(7):1066-9. PMID: 27013401.
      View in: PubMed
    53. van Haandel L, Gibson KT, Leeder JS, Wagner JB. Quantification of pravastatin acid, lactone and isomers in human plasma by UHPLC-MS/MS and its application to a pediatric pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Feb 15; 1012-1013:169-77. PMID: 26849185.
      View in: PubMed
    54. Vyhlidal CA, Bi C, Ye SQ, Leeder JS. Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers. Drug Metab Dispos. 2016 07; 44(7):1020-6. PMID: 26772622.
      View in: PubMed
    55. Twist GP, Gaedigk A, Miller NA, Farrow EG, Willig LK, Dinwiddie DL, Petrikin JE, Soden SE, Herd S, Gibson M, Cakici JA, Riffel AK, Leeder JS, Dinakarpandian D, Kingsmore SF. Constellation: a tool for rapid, automated phenotype assignment of a highly polymorphic pharmacogene, CYP2D6, from whole-genome sequences. NPJ Genom Med. 2016; 1:15007. PMID: 29263805.
      View in: PubMed
    56. Riffel AK, Dehghani M, Hartshorne T, Floyd KC, Leeder JS, Rosenblatt KP, Gaedigk A. CYP2D7 Sequence Variation Interferes with TaqMan CYP2D6 (*) 15 and (*) 35 Genotyping. Front Pharmacol. 2015; 6:312. PMID: 26793106.
      View in: PubMed
    57. Brown JT, Abdel-Rahman SM, van Haandel L, Gaedigk A, Lin YS, Leeder JS. Single dose, CYP2D6 genotype-stratified pharmacokinetic study of atomoxetine in children with ADHD. Clin Pharmacol Ther. 2016 06; 99(6):642-50. PMID: 26660002.
      View in: PubMed
    58. Neville, KA Leeder JS. In: Nelson Textbook of Pediatrics, 20th Edition, Kliegman RM, Stanton BF, St. Geme III JW, Schor NF, (Eds). Chapter 59: Pediatric Pharmacogenetics, Pharmacogenomics and Pharmacoproteomics. Elsevier, Philadephia. 2016.
    59. Becker ML, Dovell D, Leeder JS. In: Textbook of Pediatric Rheumatology, Seventh Edition, Petty RE, Laxer RM, Lindsley CB, Wedderburn LR, (Eds). Chapter 12: Pharmacology and Drug Therapy: Nonbiologic Therapies. Elsevier, Phildelphia. 2016.
    60. Pearce RE, Gaedigk R, Twist GP, Dai H, Riffel AK, Leeder JS, Gaedigk A. Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation. Drug Metab Dispos. 2016 07; 44(7):948-58. PMID: 26608082.
      View in: PubMed
    61. Gaedigk A, Riffel AK, Leeder JS. CYP2D6 Haplotype Determination Using Long Range Allele-Specific Amplification: Resolution of a Complex Genotype and a Discordant Genotype Involving the CYP2D6*59 Allele. J Mol Diagn. 2015 Nov; 17(6):740-8. PMID: 26335396.
      View in: PubMed
    62. Brouwer KL, Aleksunes LM, Brandys B, Giacoia GP, Knipp G, Lukacova V, Meibohm B, Nigam SK, Rieder M, de Wildt SN. Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group. Clin Pharmacol Ther. 2015 Sep; 98(3):266-87. PMID: 26088472.
      View in: PubMed
    63. Lewis T, Dinh J, Leeder JS. Genetic determinants of fetal opiate exposure and risk of neonatal abstinence syndrome: Knowledge deficits and prospects for future research. Clin Pharmacol Ther. 2015 Sep; 98(3):309-20. PMID: 26058918.
      View in: PubMed
    64. Preuett B, Leeder JS, Abdel-Rahman S. Development and Application of a High-Throughput Screening Method to Evaluate Antifungal Activity against Trichophyton tonsurans. J Biomol Screen. 2015 Oct; 20(9):1171-7. PMID: 26160833.
      View in: PubMed
    65. Goldman JL, Leeder JS, Van Haandel L, Pearce RE. In Vitro Hepatic Oxidative Biotransformation of Trimethoprim. Drug Metab Dispos. 2015 Sep; 43(9):1372-80. PMID: 26138612.
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    261. Leeder JS, Cannon M, Nakhooda A, Spielberg SP. Drug metabolite toxicity assessed in human lymphocytes with a purified, reconstituted cytochrome P-450 system. J Pharmacol Exp Ther. 1988 Jun; 245(3):956-62. PMID: 3385648.
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    262. Leeder JS and Gold R. In: Antimicrobial Therapy in Infants and Children. Koren G, Gold R and Prober C, Ed. Cephalosporins. Marcel Dekker, New York. 1988; 173-235.
    263. Mahon WA, Leeder JS, Brill-Edwards MM, Correia J, MacLeod SM. Comparative bioavailability study of three sustained release quinidine formulations. Clin Pharmacokinet. 1987 Aug; 13(2):118-24. PMID: 3621768.
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    264. Holland FJ, Fishman L, Costigan DC, Luna L, Leeder S. Pharmacokinetic characteristics of the gonadotropin-releasing hormone analog D-Ser(TBU)-6EA-10luteinizing hormone-releasing hormone (buserelin) after subcutaneous and intranasal administration in children with central precocious puberty. J Clin Endocrinol Metab. 1986 Nov; 63(5):1065-70. PMID: 3093518.
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    265. Leeder JS, Robertson C, Correia J, Isles AF, Levison H, Macleod SM. Evaluation of serum theophylline concentrations following administration of sustained-release beads in applesauce to asthmatic preschool children. Ann Allergy. 1986 Feb; 56(2):133-7. PMID: 3946845.
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    266. Leeder JS, Isles AF, Robertson CF, Correia J, Levison H and MacLeod SM. In: Childhood Asthma and Sustained Release Theophylline. MacLeod SM and Szefler S, Eds. Assessment of beaded sustained release theophylline preparations. Excerpta Medica, Amsterdam. 1986; 114-126.
    267. Koren G, Lavi S, Greenwald M, Roifman C, Leeder JS, Gelfand EW, MacLeod SM. Cerebrospinal fluid pharmacokinetics of tobramycin, ceftazidime, phenobarbitone and phenytoin in a child. Clin Pharmacokinet. 1985 Jul-Aug; 10(4):371-5. PMID: 3899453.
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    268. Koren G, Leeder S, Harding E, Jacques D, MacLeod SM. Optimization of gentamicin therapy in very low birth weight infants. Pediatr Pharmacol (New York). 1985; 5(1):79-87. PMID: 3991255.
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    269. Leeder JS, Spino M, Isles AF, Tesoro AM, Gold R, MacLeod SM. Ceftazidime disposition in acute and stable cystic fibrosis. Clin Pharmacol Ther. 1984 Sep; 36(3):355-62. PMID: 6432400.
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    270. Peterson CD, Leeder JS, Sterner S. Glucagon therapy for beta-blocker overdose. Drug Intell Clin Pharm. 1984 May; 18(5):394-8. PMID: 6144498.
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    271. Leeder JS and MacLeod SM: . Acetaminophen overdose. Med North Amer. 1984; 2:1462-1464.
    272. Leeder JS: Minor side effects of OCs - . evaluation and management. On Cont Pract. 1984; 3(11):34-38.
    273. St. Pierre MV, Leeder JS, Spino M, Isles A and MacLeod SM:. Circadian variation in theophylline absorption. Ann Rev Chronopharmacol. 1984; 1:81-84.
    274. Isles AF, Leeder JS, Spino M and MacLeod SM. Bioavailability of Somophylline-CRT capsules. Br J Clin Pract. 1984; 35:68-70.
    275. Leeder JS, Tesoro AM, Bertho-Gebara CE and MacLeod SM. Comparative bioavailability of ranitidine tablets and suspension. Can J Hosp Pharm. 1984; 37:92-94.
    276. Leeder JS, Spielberg SP, MacLeod SM. Bendectin: the wrong way to regulate drug availability. Can Med Assoc J. 1983 Nov 15; 129(10):1085-7. PMID: 6627167.
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    277. Leeder JS, Spino M, Tesoro AM, MacLeod SM. High-pressure liquid chromatographic analysis of ceftazidime in serum and urine. Antimicrob Agents Chemother. 1983 Nov; 24(5):720-4. PMID: 6362554.
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