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Susana Chavez-Bueno, MD

TitlePhysician
InstitutionChildren's Mercy Kansas City
DepartmentPediatrics
Address2401 Gillham Rd
Kansas City MO 64108
ORCID ORCID Icon0000-0001-8371-5463 Additional info
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    Other Positions
    TitleAssociate Professor of Pediatrics
    InstitutionUniversity of Missouri-Kansas City
    DepartmentPediatrics


    Collapse Biography 
    Collapse education and training
    National Autonomous University of Mexico, Mexico CityMD1997
    Children's Hospital of Oklahoma, Oklahoma City, OKResidency2001Pediatrics
    University of Texas Southwestern Medical Center, Dallas, TXFellowship2004Pediatric Infectious Disease
    University of Texas Southwestern Medical Center at Dallas, Dallas, TX2005Postdoctoral Researcher
    Collapse awards and honors
    2015 - 2016Best Doctors in America, Oklahoma Magazine
    2013Research Mentor Award, OUHSC Department of Pediatrics Research
    2001The Harris D. Riley, Jr. Pediatric Society’s Award, Children’s Hospital of Oklahoma

    Collapse Overview 

    Collapse Research 
    Collapse research overview
    Dr. Chavez-Bueno’s current research work focuses on the pathogenesis of E. coli sepsis in newborns. Her overall research goal is to identify novel virulence factors relevant to the pathogen’s ability to traverse the gut and invade the bloodstream causing neonatal sepsis. Her studies utilize in vitro and in animal models designed to characterize the bacterial components that determine invasion and trafficking across intestinal epithelium and interact with gut specific immune regulators as potential therapeutic targets to decrease life-threatening neonatal E. coli disease.
    Dr. Chavez-Bueno is an elected member of the Society for Pediatric Research and currently serves on the Research Committee for the Infectious Diseases Society of America.
    Collapse research activities and funding
         (Chavez-Bueno)Jan 1, 2002 - Dec 31, 2004
    Pediatric Infectious Disease Society (PIDS) Fellowship Award
    Chemokines in RSV-Induced Airway Hyperresponsiveness

         (Chavez-Bueno)Jan 1, 2003 - Dec 31, 2003
    Clinical Research Support Individual Project Grant, Children’s Medical Center of Dallas
    Project title: Respiratory Syncytial Virus (RSV) Quantification by Real Time Polymerase Chain Reaction and Markers of Disease Severity in Children

    MI-CP146     Jan 1, 2007 - Dec 31, 2008
    MedImmune
    A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate a Single Intramuscular Dose of Motavizumab (MEDI-524), a Humanized Enhanced Potency Monoclonal Antibody Against Respiratory Syncytial Virus (RSV), for the Outpatient Treatment of Children with RSV Illness
    Role: Principal Investigator

    MI-CP141     Jan 1, 2007 - Dec 31, 2010
    MedImmune
    A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate a Single Intravenous Dose of Motavizumab (MEDI-524), a Humanized Enhanced Potency Monoclonal Antibody Against Respiratory Syncytial Virus (RSV), for the Treatment of Children Hospitalized with RSV Illness
    Role: Site Principal Investigator

         Jan 1, 2008 - Dec 31, 2009
    ADMA Biologics, Inc
    A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Dose-Ranging Trial Evaluating the Safety and Efficacy of RI-001 in Medically Immunosupressed Respiratory Syncytial Virus (RSV) Infected Patients at Risk of Lower Respiratory Tract RSV Illness
    Role: Site Principal Investigator

         Jan 1, 2008 - Dec 31, 2013
    Cubist Pharmaceuticals, Inc
    An Evaluation of the Safety, Efficacy and Pharmacokinetics of Daptomycin in Pediatric Subjects Aged Seven to Seventeen Years with Complicated Skin and Skin Structure Infections Caused by Gram-Positive Pathogens
    Role: Site Principal Investigator

         Jan 1, 2010 - Dec 31, 2011
    LaRoche Hoffmann LTD
    An Open Label, Prospective, Pharmacokinetic/Pharmacodynamic and Safety Evaluation of Intravenous Oseltamivir (Tamiflu®) in the Treatment of Children 1 to 12 years of age with Influenza Infection
    Role: Site Principal Investigator

         (Chavez-Bueno)Mar 1, 2012 - Feb 28, 2013
    University of Oklahoma Health Sciences Center Vicepresident for research seed grant
    Escherichia coli K1 Invasive Infections in Neonates
    Role: Principal Investigator

    DAP-PEDBAC-11-02     (Aurelia Balan)Nov 19, 2012 - Jan 31, 2014

    A Comparative Evaluation of the Safety and Efficacy of Daptomycin versus Standard of Care in Pediatric Subjects Two-Seventeen Years of Age with Bacteremia Caused by Staphylococcus aureus
    Role: Sub-investigator

    8P20GM103447     Jul 1, 2013 - Mar 31, 2014
    Oklahoma IDeA Network for Biomedical Research Excellence (INBRE), NIH/NIGMS pilot grant award
    Escherichia coli K1 Invasive Infections in Neonates
    Role: Sub-project Principal Investigator

         (Chavez-Bueno)Jul 1, 2014 - Dec 31, 2015
    OUHSC College of Medicine Alumni Association (COMAA)
    Escherichia Coli Colonization in Women in Preterm Labor
    Role: Principal Investigator

         (Akins)Jul 9, 2014 - Aug 5, 2016
    Oklahoma IDeA Network for Biomedical Research Excellence (INBRE) Grant, NIH/NIGMS grant award
    Identification of Virulence Factors in E. coli Strains Causing Neonatal Sepsis
    Role: Project Principal Investigator

         (Chavez-Bueno)Sep 1, 2014 - Aug 30, 2016
    Oklahoma Center for the Advancement of Science and Technology (OCAST)
    Bacterial Genes Relevant to Gut Translocation and Virulence in Neonatal Escherichia coli Strains
    Role: Principal Investigator

         (Hala Chaaban)Apr 1, 2015 - Aug 1, 2016

    NCT01994993: Antibiotic Safety in Infants with Complicated Intra-abdominal Infections, SCAMP Trial
    Role: Collaborator

         (Chavez-Bueno)Feb 1, 2016 - Aug 5, 2016
    Division of Neonatal-Perinatal medicine, Department of Pediatrics, OUHSC
    Exposure to low pH Reveals Virulence Factors in Neonatal Escherichia coli Bacteremia after Oral Inoculation
    Role: Principal Investigator

         (Chavez-Bueno)Oct 1, 2017 - Sep 30, 2019
    Katharine B. Richardson Foundation, Children's Mercy Hospital
    Role of Bacterial Virulence Factors in the Pathogenesis and Host Response to Neonatal Invasive E. coli Infections
    Role: Principal Investigator

         (Chavez-Bueno)Apr 1, 2018

    Proteomic profiling of neonates with suspected sepsis
    Role: Principal Investigator

         (Chavez-Bueno)Dec 1, 2018 - Nov 30, 2019
    BioNexus KC-Kansas City Area Life Sciences Institute
    Effects of Probiotics on the Intestinal Microbiome and Inflammatory Response to Infection by Bacteremia-Producing Escherichia coli
    Role: Principal Investigator

         (Chavez-Bueno)Oct 1, 2019 - Sep 30, 2021
    Marion Merrell Dow Award, , Children's Mercy Hospital
    Single Immunoglobulin Interleukin-l Related Receptor (SIGIRR) and Escherichia coli Interactions in the Neonatal Gut
    Role: Principal Investigator

    Collapse Bibliography 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Cuna A, Yu W, Menden HL, Feng L, Srinivasan P, Chavez-Bueno S, Ahmed I, Umar S, Sampath V. NEC-like intestinal injury is ameliorated by Lactobacillus rhamnosus GG in parallel with SIGIRR and A20 induction in neonatal mice. Pediatr Res. 2020 Feb 13. PMID: 32053825.
      View in: PubMed
    2. Cole BK, Ilikj M, McCloskey CB, Chavez-Bueno S. Antibiotic resistance and molecular characterization of bacteremia Escherichia coli isolates from newborns in the United States. PLoS One. 2019; 14(7):e0219352. PMID: 31276562.
      View in: PubMed
    3. Rodriguez-Fernandez R, Tapia LI, Yang CF, Torres JP, Chavez-Bueno S, Garcia C, Jaramillo LM, Moore-Clingenpeel M, Jafri HS, Peeples ME, Piedra PA, Ramilo O, Mejias A. Respiratory Syncytial Virus Genotypes, Host Immune Profiles, and Disease Severity in Young Children Hospitalized With Bronchiolitis. J Infect Dis. 2017 12 27; 217(1):24-34. PMID: 29045741.
      View in: PubMed
    4. Cole BK, Scott E, Ilikj M, Bard D, Akins DR, Dyer DW, Chavez-Bueno S. Route of infection alters virulence of neonatal septicemia Escherichia coli clinical isolates. PLoS One. 2017; 12(12):e0189032. PMID: 29236742.
      View in: PubMed
    5. Ugas MB, Carroll T, Kovar L, Chavez-Bueno S. Salmonella Typhi-Induced Septic Shock and Acute Respiratory Distress Syndrome in a Previously Healthy Teenage Patient Treated With High-Dose Dexamethasone. J Investig Med High Impact Case Rep. 2016 Apr-Jun; 4(2):2324709616652642. PMID: 27294165.
      View in: PubMed
    6. Benefield EC, Hagemann TM, Allen HC, Farmer K, Burton ME, Chavez-Bueno S, Johnson PN. Vancomycin Dosing and Pharmacokinetics in Postoperative Pediatric Cardiothoracic Surgery Patients. J Pediatr Pharmacol Ther. 2016 Jan-Feb; 21(1):66-74. PMID: 26997930.
      View in: PubMed
    7. Day MW, Jackson LA, Akins DR, Dyer DW, Chavez-Bueno S. Whole-Genome Sequences of the Archetypal K1 Escherichia coli Neonatal Isolate RS218 and Contemporary Neonatal Bacteremia Clinical Isolates SCB11, SCB12, and SCB15. Genome Announc. 2015 Feb 26; 3(1). PMID: 25720688.
      View in: PubMed
    8. Chavez-Bueno S, Day MW, Toby IT, Akins DR, Dyer DW. Genome Sequence of SCB34, a Sequence Type 131 Multidrug-Resistant Escherichia coli Isolate Causing Neonatal Early-Onset Sepsis. Genome Announc. 2014 Jun 12; 2(3). PMID: 24926049.
      View in: PubMed
    9. Shakir SM, Goldbeck JM, Robison D, Eckerd AM, Chavez-Bueno S. Genotypic and phenotypic characterization of invasive neonatal Escherichia coli clinical isolates. Am J Perinatol. 2014 Nov; 31(11):975-82. PMID: 24566757.
      View in: PubMed
    10. Miller M, Miller JL, Hagemann TM, Harrison D, Chavez-Bueno S, Johnson PN. Vancomycin dosage in overweight and obese children. Am J Health Syst Pharm. 2011 Nov 01; 68(21):2062-8. PMID: 22011985.
      View in: PubMed
    11. Chavez-Bueno S, Beasley JA, Goldbeck JM, Bright BC, Morton DJ, Whitby PW, Stull TL. 'Haptoglobin concentrations in preterm and term newborns'. J Perinatol. 2011 Jul; 31(7):500-3. PMID: 21252963.
      View in: PubMed
    12. Chávez-Bueno S, Stull TL. Pediatric vaccines on the horizon. Am J Med Sci. 2010 Sep; 340(3):226-31. PMID: 20697256.
      View in: PubMed
    13. Chavez-Bueno S, Stull TL. Antibacterial agents in pediatrics. Infect Dis Clin North Am. 2009 Dec; 23(4):865-80, viii. PMID: 19909888.
      View in: PubMed
    14. Mejías A, Chávez-Bueno S, Gómez AM, Somers C, Estripeaut D, Torres JP, Jafri HS, Ramilo O. Respiratory syncytial virus persistence: evidence in the mouse model. Pediatr Infect Dis J. 2008 Oct; 27(10 Suppl):S60-2. PMID: 18820580.
      View in: PubMed
    15. Chávez-Bueno S, Mejías A, Merryman RA, Ahmad N, Jafri HS, Ramilo O. Intravenous palivizumab and ribavirin combination for respiratory syncytial virus disease in high-risk pediatric patients. Pediatr Infect Dis J. 2007 Dec; 26(12):1089-93. PMID: 18043443.
      View in: PubMed
    16. Mejías A, Chávez-Bueno S, Raynor MB, Connolly J, Kiener PA, Jafri HS, Ramilo O. Motavizumab, a neutralizing anti-Respiratory Syncytial Virus (Rsv) monoclonal antibody significantly modifies the local and systemic cytokine responses induced by Rsv in the mouse model. Virol J. 2007 Oct 25; 4:109. PMID: 17961258.
      View in: PubMed
    17. Bogdanovich T, Aydin N, Chavez-Bueno S, McCracken G, Bozdogan B, Appelbaum PC. Genetic characterization of erythromycin- and methicillin-resistant community-acquired Staphylococcus aureus isolated from children in Texas. Diagn Microbiol Infect Dis. 2007 Oct; 59(2):231-3. PMID: 17662559.
      View in: PubMed
    18. Welliver TP, Garofalo RP, Hosakote Y, Hintz KH, Avendano L, Sanchez K, Velozo L, Jafri H, Chavez-Bueno S, Ogra PL, McKinney L, Reed JL, Welliver RC. Severe human lower respiratory tract illness caused by respiratory syncytial virus and influenza virus is characterized by the absence of pulmonary cytotoxic lymphocyte responses. J Infect Dis. 2007 Apr 15; 195(8):1126-36. PMID: 17357048.
      View in: PubMed
    19. Yusuf S, Piedimonte G, Auais A, Demmler G, Krishnan S, Van Caeseele P, Singleton R, Broor S, Parveen S, Avendano L, Parra J, Chavez-Bueno S, Murguía De Sierra T, Simoes EA, Shaha S, Welliver R. The relationship of meteorological conditions to the epidemic activity of respiratory syncytial virus. Epidemiol Infect. 2007 Oct; 135(7):1077-90. PMID: 17346359.
      View in: PubMed
    20. Salvatore CM, Fonseca-Aten M, Katz-Gaynor K, Gomez AM, Mejias A, Somers C, Chavez-Bueno S, McCracken GH, Hardy RD. Respiratory tract infection with Mycoplasma pneumoniae in interleukin-12 knockout mice results in improved bacterial clearance and reduced pulmonary inflammation. Infect Immun. 2007 Jan; 75(1):236-42. PMID: 17074851.
      View in: PubMed
    21. Fonseca-Aten M, Okada PJ, Bowlware KL, Chavez-Bueno S, Mejias A, Rios AM, Katz K, Olsen K, Ng S, Jafri HS, McCracken GH, Ramilo O, Hardy RD. Effect of clarithromycin on cytokines and chemokines in children with an acute exacerbation of recurrent wheezing: a double-blind, randomized, placebo-controlled trial. Ann Allergy Asthma Immunol. 2006 Oct; 97(4):457-63. PMID: 17069099.
      View in: PubMed
    22. Fonseca-Aten M, Rios AM, Mejias A, Chavez-Bueno S, Katz K, Gomez AM, Ramilo O, McCracken GH, Hardy RD. Treatment of experimental chronic pulmonary mycoplasmosis. Int J Antimicrob Agents. 2006 Sep; 28(3):253-8. PMID: 16891098.
      View in: PubMed
    23. Chávez-Bueno S, Mejías A, Welliver RC. Respiratory syncytial virus bronchiolitis : current and future strategies for treatment and prophylaxis. Treat Respir Med. 2006; 5(6):483-94. PMID: 17154675.
      View in: PubMed
    24. Mejías A, Chávez-Bueno S, Jafri HS, Ramilo O. Respiratory syncytial virus infections: old challenges and new opportunities. Pediatr Infect Dis J. 2005 Nov; 24(11 Suppl):S189-96, discussion S196-7. PMID: 16378045.
      View in: PubMed
    25. Mejías A, Chávez-Bueno S, Ríos AM, Aten MF, Raynor B, Peromingo E, Soni P, Olsen KD, Kiener PA, Gómez AM, Jafri HS, Ramilo O. Comparative effects of two neutralizing anti-respiratory syncytial virus (RSV) monoclonal antibodies in the RSV murine model: time versus potency. Antimicrob Agents Chemother. 2005 Nov; 49(11):4700-7. PMID: 16251314.
      View in: PubMed
    26. Fonseca-Aten M, Salvatore CM, Mejías A, Ríos AM, Chávez-Bueno S, Katz K, Gómez AM, McCracken GH, Hardy RD. Evaluation of LBM415 (NVP PDF-713), a novel peptide deformylase inhibitor, for treatment of experimental Mycoplasma pneumoniae pneumonia. Antimicrob Agents Chemother. 2005 Oct; 49(10):4128-36. PMID: 16189089.
      View in: PubMed
    27. Ríos AM, Fonseca-Aten M, Mejías A, Chávez-Bueno S, Katz K, Gómez AM, McCracken GH, Ramilo O, Hardy RD. Microbiologic and immunologic evaluation of a single high dose of azithromycin for treatment of experimental Mycoplasma pneumoniae pneumonia. Antimicrob Agents Chemother. 2005 Sep; 49(9):3970-3. PMID: 16127085.
      View in: PubMed
    28. Mejías A, Chávez-Bueno S, Ramilo O. Respiratory syncytial virus pneumonia: mechanisms of inflammation and prolonged airway hyperresponsiveness. Curr Opin Infect Dis. 2005 Jun; 18(3):199-204. PMID: 15864095.
      View in: PubMed
    29. Chávez-Bueno S, McCracken GH. Bacterial meningitis in children. Pediatr Clin North Am. 2005 Jun; 52(3):795-810, vii. PMID: 15925663.
      View in: PubMed
    30. Chavez-Bueno S, Bozdogan B, Katz K, Bowlware KL, Cushion N, Cavuoti D, Ahmad N, McCracken GH, Appelbaum PC. Inducible clindamycin resistance and molecular epidemiologic trends of pediatric community-acquired methicillin-resistant Staphylococcus aureus in Dallas, Texas. Antimicrob Agents Chemother. 2005 Jun; 49(6):2283-8. PMID: 15917522.
      View in: PubMed
    31. Chávez-Bueno S, Mejías A, Gómez AM, Olsen KD, Ríos AM, Fonseca-Aten M, Ramilo O, Jafri HS. Respiratory syncytial virus-induced acute and chronic airway disease is independent of genetic background: an experimental murine model. Virol J. 2005 May 25; 2:46. PMID: 15916706.
      View in: PubMed
    32. Chávez-Bueno S, Mejías A, Jafri HS, Ramilo O. Respiratory syncytial virus: old challenges and new approaches. Pediatr Ann. 2005 Jan; 34(1):62-8. PMID: 15693217.
      View in: PubMed
    33. Fonseca-Aten M, Ríos AM, Mejías A, Chávez-Bueno S, Katz K, Gómez AM, McCracken GH, Hardy RD. Mycoplasma pneumoniae induces host-dependent pulmonary inflammation and airway obstruction in mice. Am J Respir Cell Mol Biol. 2005 Mar; 32(3):201-10. PMID: 15626776.
      View in: PubMed
    34. Mejías A, Chávez-Bueno S, Ríos AM, Fonseca-Aten M, Gómez AM, Jafri HS, Ramilo O. [Asthma and respiratory syncytial virus. New opportunities for therapeutic intervention]. An Pediatr (Barc). 2004 Sep; 61(3):252-60. PMID: 15469810.
      View in: PubMed
    35. Ríos AM, Mejías A, Chávez-Bueno S, Fonseca-Aten M, Katz K, Hatfield J, Gómez AM, Jafri HS, McCracken GH, Ramilo O, Hardy RD. Impact of cethromycin (ABT-773) therapy on microbiological, histologic, immunologic, and respiratory indices in a murine model of Mycoplasma pneumoniae lower respiratory infection. Antimicrob Agents Chemother. 2004 Aug; 48(8):2897-904. PMID: 15273098.
      View in: PubMed
    36. Mejías A, Chávez-Bueno S, Ríos AM, Saavedra-Lozano J, Fonseca Aten M, Hatfield J, Kapur P, Gómez AM, Jafri HS, Ramilo O. Anti-respiratory syncytial virus (RSV) neutralizing antibody decreases lung inflammation, airway obstruction, and airway hyperresponsiveness in a murine RSV model. Antimicrob Agents Chemother. 2004 May; 48(5):1811-22. PMID: 15105140.
      View in: PubMed
    37. Jafri HS, Chavez-Bueno S, Mejias A, Gomez AM, Rios AM, Nassi SS, Yusuf M, Kapur P, Hardy RD, Hatfield J, Rogers BB, Krisher K, Ramilo O. Respiratory syncytial virus induces pneumonia, cytokine response, airway obstruction, and chronic inflammatory infiltrates associated with long-term airway hyperresponsiveness in mice. J Infect Dis. 2004 May 15; 189(10):1856-65. PMID: 15122522.
      View in: PubMed
    38. Mejías A, Chávez-Bueno S, Ramilo O. Human metapneumovirus: a not so new virus. Pediatr Infect Dis J. 2004 Jan; 23(1):1-7; quiz 8-10. PMID: 14743038.
      View in: PubMed
    39. Hardy RD, Rios AM, Chavez-Bueno S, Jafri HS, Hatfield J, Rogers BB, McCracken GH, Ramilo O. Antimicrobial and immunologic activities of clarithromycin in a murine model of Mycoplasma pneumoniae-induced pneumonia. Antimicrob Agents Chemother. 2003 May; 47(5):1614-20. PMID: 12709330.
      View in: PubMed
    40. Mendoza-Alvarez H, Chavez-Bueno S, Alvarez-Gonzalez R. Chain length analysis of ADP-ribose polymers generated by poly(ADP-ribose) polymerase (PARP) as a function of beta-NAD+ and enzyme concentrations. IUBMB Life. 2000 Aug; 50(2):145-9. PMID: 11185961.
      View in: PubMed
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