 Methotrexate
"Methotrexate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
| Descriptor ID |
D008727
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| MeSH Number(s) |
D03.438.733.631.192.500
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| Concept/Terms |
Methotrexate Sodium- Methotrexate Sodium
- Sodium, Methotrexate
- Methotrexate, Disodium Salt
- Methotrexate, Sodium Salt
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Below are MeSH descriptors whose meaning is more general than "Methotrexate".
Below are MeSH descriptors whose meaning is more specific than "Methotrexate".
This graph shows the total number of publications written about "Methotrexate" by people in this website by year, and whether "Methotrexate" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 5 | 1 | 6 | | 2012 | 2 | 0 | 2 | | 2013 | 2 | 1 | 3 | | 2014 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 1 | 2 | | 2018 | 1 | 1 | 2 | | 2019 | 1 | 3 | 4 | | 2020 | 1 | 0 | 1 | | 2021 | 2 | 0 | 2 | | 2022 | 0 | 1 | 1 | | 2023 | 1 | 0 | 1 | | 2024 | 4 | 1 | 5 | | 2025 | 2 | 1 | 3 | | 2026 | 2 | 0 | 2 |
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Below are the most recent publications written about "Methotrexate" by people in Profiles.
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Taylor ZL, Barreto EF, Cole KC, Rule AD, Kashani KB, Leung N, Thompson CA, Witzig TE, Ramsey LB, Barreto JN. Use of a Cystatin C-Based GFR Equation in a Population Pharmacokinetic Model of Methotrexate Clearance in Adult Patients with Lymphoma. Clin Pharmacokinet. 2026 Mar; 65(3):465-477.
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Gooden F, Meier BD, Shaffer GD, Gibson K, Toren P, Punt NC, Subash S, Singh DK, Prasad B, Ramsey LB, Taylor ZL. Pharmacogenetic hSLCO1B1*14-Guided Dosing of Methotrexate in Transgenic Arthritic Mice Normalizes Exposure and Response. Clin Transl Sci. 2026 Jan; 19(1):e70449.
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Taylor ZL, Miller TP, Board SG, Poweleit EA, Chavana A, Weisnicht A, Brown AL, Bernhardt MB, Schafer ES, O'Brien MM, Castellino SM, Ramsey LB. What Is the Expected Clearance of Methotrexate? A Therapeutic Drug Monitoring Reference Guide for High-Dose Methotrexate Use in Pediatric Malignancies. Pediatr Blood Cancer. 2025 Jul; 72(7):e31744.
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Heldrup J, Bleyer A, Ramsey L, Schaff L, Bernhardt B, Schwartz S, Chatelut E, Hwang M, Ten C, Guscott M, Howard S. New recommendations for reversal of high-dose methotrexate cytotoxicity with folinic acid. Cancer Chemother Pharmacol. 2025 Mar 13; 95(1):41.
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Harris JG, Holland MJ, Fox E, Favier L, Hoffart C, Ibarra M, Jones JT, Harris LA, Cooper AM. Optimizing laboratory medication safety monitoring in patients with juvenile idiopathic arthritis to advance value-based care. Clin Rheumatol. 2025 Mar; 44(3):1293-1297.
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Chang MH, Barbar-Smiley F, Akoghlanian S, Drew J, Angeles-Han ST, Quinlan-Waters M, Bohnsack JF, Cooper AM, Edelheit B, Twachtman-Bassett J, Lerman MA, Nanda K, Rabinovich CE, Lo MS. Implementation study of the CARRA Uveitis Consensus Treatment Plans: feasibility for clinical practice and applicability for research. Pediatr Rheumatol Online J. 2024 Oct 07; 22(1):88.
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Christensen SR, Jensen CF, Heldrup J, Taylor Z, Ramsey LB, Rosth?j S. Hypoalbuminemia in children with acute lymphoblastic leukemia: relation to asparaginase therapy and impact on high dose methotrexate elimination. Cancer Chemother Pharmacol. 2024 Dec; 94(6):775-785.
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Tentoni N, Hwang M, Villanueva G, Combs R, Lowe J, Ramsey LB, Taylor ZL, Carrillo TM, Aumente MD, L?pez-Vi?au L?pez T, Rizzari C, Howard SC. Early therapeutic drug monitoring of methotrexate and its association with acute kidney injury: A retrospective cohort study. Cancer Med. 2024 Sep; 13(17):e70176.
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Mandel M, Elhusseiny AM, Davidson SL, Rockter A, Levin AV, Huang LC, Cheung CSY, Stahl ED, Cooper AM, Jin J, Inger HE, Jordan CO, Jung JL, Utz VM, Angeles-Han ST, Oke I, Nihalani BR. Clinical outcomes in paediatric tubulointerstitial nephritis and uveitis syndrome (TINU). Eye (Lond). 2024 Dec; 38(17):3318-3324.
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Chavana AN, Taylor ZL, DeGroote N, Lindsay HB, Sauer HE, Mason EJ, Schafer ES, Miller TP, Castellino SM, Pommert L, O'Brien MM, Ramsey LB, Bernhardt MB, Brown AL. Toxicity profile of high-dose methotrexate in young children with central nervous system tumors. Pediatr Blood Cancer. 2024 Oct; 71(10):e31213.
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