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Fridley, Brooke

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Dr. Fridley joined Children’s Mercy in December of 2023 as the Director of the Biostatistics and Epidemiology Core within the Division of Health Services and Outcomes Research. She is also Professor of Pediatrics at the University of Missouri – Kansas City and is a member of the University of Kansas Cancer Center (KUCC). Before joining Children’s Mercy, she was the Chair of the Department of Biostatistics and Bioinformatics and Scientific Director for the CCSG Biostatistics and Bioinformatics Shared Resource at Moffitt Cancer Center in Tampa, FL. She has extensive experience as a collaborating biostatistician and has worked on numerous cancer research studies over the course of her career. These research collaborations have resulted in over 290 publications and 6 NIH grants for which she was Principal Investigator. She also has extensive experience mentoring trainees and was MPI of a T32 entitled “Integrative Program in Cancer and Data Science” from NIH/NCI. The Fridley lab is focused on development of novel statistical and bioinformatic methods to answer questions that arise in cancer research. Recently, her lab has been working on analytical methods for understanding the spatial architecture of the tumor immune microenvironment and how this is related to clinical outcomes by leveraging the information from spatial single-cell protein and spatial transcriptomic experiments.

One or more keywords matched the following items that are connected to Fridley, Brooke

Item Type	Name
Concept	Feasibility Studies
Concept	Follow-Up Studies
Concept	Longitudinal Studies
Concept	Prospective Studies
Concept	Retrospective Studies
Concept	Sampling Studies
Concept	Cohort Studies
Concept	Epidemiologic Studies
Concept	Case-Control Studies
Concept	Genetic Association Studies
Academic Article	Betaine-homocysteine methyltransferase: human liver genotype-phenotype correlation.
Academic Article	Subject level clustering using a negative binomial model for small transcriptomic studies.
Academic Article	Pilot Study in Investigating Material Financial Toxicity Markers by Age in Cancer Patients.
Academic Article	PARP1 and POLD2 as prognostic biomarkers for multiple myeloma in autologous stem cell transplant.
Academic Article	Associations between prediagnostic aspirin use and ovarian tumor gene expression.
Academic Article	The relationship of lifetime history of depression on the ovarian tumor immune microenvironment.
Academic Article	Measurement of Ovarian Tumor Immune Profiles by Multiplex Immunohistochemistry: Implications for Epidemiologic Studies.
Academic Article	Bayseian genomic models for the incorporation of pathway topology knowledge into association studies.
Academic Article	Risk of ovarian cancer and the NF-?B pathway: genetic association with IL1A and TNFSF10.
Academic Article	Integrative genomic analysis identifies epigenetic marks that mediate genetic risk for epithelial ovarian cancer.
Academic Article	Acquired chromosomal anomalies in chronic lymphocytic leukemia patients compared with more than 50,000 quasi-normal participants.
Academic Article	Genome-wide investigation of regional blood-based DNA methylation adjusted for complete blood counts implicates BNC2 in ovarian cancer.
Academic Article	Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk.
Academic Article	Genetic variation in platinating agent and taxane pathway genes as predictors of outcome and toxicity in advanced non-small-cell lung cancer.
Academic Article	Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk.
Academic Article	Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study.
Academic Article	Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk.
Academic Article	Shared genetics underlying epidemiological association between endometriosis and ovarian cancer.
Academic Article	Modulation of Breast Cancer Risk Biomarkers by High-Dose Omega-3 Fatty Acids: Phase II Pilot Study in Postmenopausal Women.
Academic Article	Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer.
Academic Article	Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer.
Academic Article	Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer.
Academic Article	Modulation of Breast Cancer Risk Biomarkers by High-Dose Omega-3 Fatty Acids: Phase II Pilot Study in Premenopausal Women.
Academic Article	Prior oral contraceptive use in ovarian cancer patients: assessing associations with overall and progression-free survival.
Academic Article	CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer.
Academic Article	Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.
Academic Article	PPM1D Mosaic Truncating Variants in Ovarian Cancer Cases May Be Treatment-Related Somatic Mutations.
Academic Article	Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer.
Academic Article	A targeted genetic association study of epithelial ovarian cancer susceptibility.
Academic Article	The association between socioeconomic status and tumour stage at diagnosis of ovarian cancer: A pooled analysis of 18 case-control studies.
Academic Article	Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium.
Academic Article	PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.
Academic Article	Risk Prediction for Epithelial Ovarian Cancer in 11 United States-Based Case-Control Studies: Incorporation of Epidemiologic Risk Factors and 17 Confirmed Genetic Loci.
Academic Article	Comprehensive Cross-Population Analysis of High-Grade Serous Ovarian Cancer Supports No More Than Three Subtypes.
Academic Article	Genetic variations associated with gemcitabine treatment outcome in pancreatic cancer.
Academic Article	Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies.
Academic Article	Characterization of fusion genes in common and rare epithelial ovarian cancer histologic subtypes.
Academic Article	Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence.
Academic Article	Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer.
Academic Article	Gene Expression, and Fatigue in Puerto Rican Men during Radiotherapy for Prostate Cancer: an Exploratory Study.
Academic Article	Mediation analysis of alcohol consumption, DNA methylation, and epithelial ovarian cancer.
Academic Article	Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.
Academic Article	Transcriptomic Characterization of Endometrioid, Clear Cell, and High-Grade Serous Epithelial Ovarian Carcinoma.
Academic Article	Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility.
Academic Article	Heterogeneous expression of cytokines accounts for clinical diversity and refines prognostication in CMML.
Academic Article	Assessment of ASC specks as a putative biomarker of pyroptosis in myelodysplastic syndromes: an observational cohort study.
Academic Article	rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology.
Academic Article	Comparison of normalization approaches for gene expression studies completed with high-throughput sequencing.
Academic Article	Lenalidomide-based response-adapted therapy for older adults without high risk myeloma.
Academic Article	Molecular signatures of X chromosome inactivation and associations with clinical outcomes in epithelial ovarian cancer.
Academic Article	Genome-wide Analysis of Common Copy Number Variation and Epithelial Ovarian Cancer Risk.
Academic Article	Outcomes of selective whole breast irradiation following lumpectomy with intraoperative radiation therapy for hormone receptor positive breast cancer.
Academic Article	Statistical genomics in rare cancer.
Academic Article	Prospective CYP2C19-Guided Voriconazole Prophylaxis in Patients With Neutropenic Acute Myeloid Leukemia Reduces the Incidence of Subtherapeutic Antifungal Plasma Concentrations.
Academic Article	Patterns and predictors of genetic referral among ovarian cancer patients at a National Cancer Institute-Comprehensive Cancer Center.
Academic Article	Implant-sparing Mastectomy: An Alternative for Women Undergoing Mastectomy With Retropectoral Implants.
Academic Article	Phase II trial of gemcitabine and nab-paclitaxel in patients with recurrent Ewing sarcoma: A report from the National Pediatric Cancer Foundation.
Academic Article	Utility of Taking Additional Margins When Performing Breast-Conserving Surgery with Intraoperative Radiation Therapy for Early Breast Cancer.
Academic Article	Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer.
Academic Article	Clinical Trial Availability by Location for 1000 Simulated AYA Patients.
Academic Article	Mitochondrial DNA sequence variation and risk of meningioma.
Academic Article	Mitochondrial DNA sequence variation and risk of glioma.
Academic Article	Prospective Analyses of Sedentary Behavior in Relation to Risk of Ovarian Cancer.
Academic Article	Lifetime ovulatory years and ovarian cancer gene expression profiles.
Academic Article	Prognostic features of endometrial cancer metastasis to the central nervous system.
Academic Article	Imputation methods for missing data for polygenic models.
Academic Article	Missing phenotype data imputation in pedigree data analysis.
Academic Article	Comparison of variable and model selection methods for genetic association studies using the GAW15 simulated data.
Academic Article	Density of common complex ocular traits in the aging eye: analysis of secondary traits in genome-wide association studies.
Academic Article	Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic.
Academic Article	Bayesian variable and model selection methods for genetic association studies.
Academic Article	Evaluation of clustering and genotype distribution for replication in genome wide association studies: the age-related eye disease study.
Academic Article	Genome-wide linkage analysis for uric acid in families enriched for hypertension.
Academic Article	Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk.
Academic Article	Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer.
Academic Article	Polymorphisms in NF-kappaB inhibitors and risk of epithelial ovarian cancer.
Academic Article	A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.
Academic Article	No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer.
Academic Article	Risk of ovarian cancer and inherited variants in relapse-associated genes.
Academic Article	Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium.
Academic Article	Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer.
Academic Article	Familial aggregation of irritable bowel syndrome: a family case-control study.
Academic Article	Localizing putative markers in genetic association studies by incorporating linkage disequilibrium into bayesian hierarchical models.
Academic Article	Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium.
Academic Article	Bayesian mixture models for the incorporation of prior knowledge to inform genetic association studies.
Academic Article	A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.
Academic Article	Common variants at 19p13 are associated with susceptibility to ovarian cancer.
Academic Article	Genome-wide association analyses of genetic, phenotypic, and environmental risks in the age-related eye disease study.
Academic Article	Distinct germ line polymorphisms underlie glioma morphologic heterogeneity.
Academic Article	Mycophenolic acid response biomarkers: a cell line model system-based genome-wide screen.
Academic Article	Prostate cancer susceptibility polymorphism rs2660753 is not associated with invasive ovarian cancer.
Academic Article	Inherited variants in mitochondrial biogenesis genes may influence epithelial ovarian cancer risk.
Academic Article	Inflammation-related gene variants as risk factors for pancreatic cancer.
Academic Article	LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer.
Academic Article	Polymorphisms in stromal genes and susceptibility to serous epithelial ovarian cancer: a report from the Ovarian Cancer Association Consortium.
Academic Article	A latent model for prioritization of SNPs for functional studies.
Academic Article	Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking.
Academic Article	Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers.
Academic Article	Association of TNFSF8 polymorphisms with peripheral neutrophil count.
Academic Article	Common variation in Nemo-like kinase is associated with risk of ovarian cancer.
Academic Article	Ovarian cancer risk associated with inherited inflammation-related variants.
Academic Article	Gene set analysis of survival following ovarian cancer implicates macrolide binding and intracellular signaling genes.
Academic Article	Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies.
Academic Article	Genetic association studies of copy-number variation: should assignment of copy number states precede testing?
Academic Article	Identification of a novel percent mammographic density locus at 12q24.
Academic Article	European American stratification in ovarian cancer case control data: the utility of genome-wide data for inferring ancestry.
Academic Article	Simultaneous analysis of multiple data types in pharmacogenomic studies using weighted sparse canonical correlation analysis.
Academic Article	Human liver methionine cycle: MAT1A and GNMT gene resequencing, functional genomics, and hepatic genotype-phenotype correlation.
Academic Article	Genome-wide association study of glioma and meta-analysis.
Academic Article	A low-frequency variant at 8q24.21 is strongly associated with risk of oligodendroglial tumors and astrocytomas with IDH1 or IDH2 mutation.
Academic Article	ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium.
Academic Article	Localization of association signal from risk and protective variants in sequencing studies.
Academic Article	Inherited variant on chromosome 11q23 increases susceptibility to IDH-mutated but not IDH-normal gliomas regardless of grade or histology.
Academic Article	Inherited variants in regulatory T cell genes and outcome of ovarian cancer.
Academic Article	Cigarette smoking and risk of ovarian cancer: a pooled analysis of 21 case-control studies.
Academic Article	Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer.
Academic Article	Analysis of over 10,000 Cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome.
Academic Article	TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression.
Academic Article	GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
Academic Article	Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.
Academic Article	Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study.
Academic Article	Biomarker-based ovarian carcinoma typing: a histologic investigation in the ovarian tumor tissue analysis consortium.

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