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Yadav, Vivekanand
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keywords
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DIPG, DMG, Pediatric Brain Tumors, Genomic and Epigenetic Mechanism of Brain tumors
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research overview
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Diffuse midline gliomas (DMGs) are the most aggressive pediatric high-grade gliomas and are the leading cause of cancer-related deaths in children. At present, there are no effective therapies for DMGs tumors, and over 90% of patients die within 1.5 years of diagnosis. In his lab, Dr. Yadav is leading efforts to understand genetic and epigenetic dependencies and signaling pathways that arise as a consequence of the H3K27M mutation in DMG. His lab performs pre-clinical studies using a novel in utero electroporation (IUE)-derived genetically engineered mouse model to identify promising candidates that can be targeted as therapy for the treatment of DMG.
1-Identifying genomic and epigenetic drivers of pediatric brain tumors with specific genetic alterations (H3K27M or H3G34R/V) using next-generation sequencing and a novel in utero electroporation (IUE) genetically engineered mouse model.
2-Developing more effective treatments by dissecting the resistance mechanisms of pediatric brain tumors using genome-wide CRISPR-based genetic screens.
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Yadav, Vivekanand