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Search Results to Jay Vivian

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One or more keywords matched the following properties of Vivian, Jay

keywords mouse models
research overview Dr. Vivian's research uses the mouse and pluripotent stem cells as genetic models of disease, to understand the basis of various disorders and for therapeutic discovery. These efforts leverage expertise in stem cell biology, mouse experimental genetics, molecular biology, genetic engineering, and developmental biology. A major focus of his lab involves the development and analysis of animal and pluripotent stem cell models of rare pediatric congenital disorders, using the genetic data mapped by human genetics studies focused on pediatric neurological disorders. These collaborative translational efforts make substantial use of genome editing to engineer genetically modified mice and patient-specific induced pluripotent stem cells for therapeutic discovery.

One or more keywords matched the following items that are connected to Vivian, Jay

Item TypeName
Concept Mice, Inbred C57BL
Concept Mice, Inbred Strains
Concept Mice, Mutant Strains
Concept Mice, Transgenic
Concept Mice, Knockout
Concept Mice
Academic Article Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac.
Academic Article Transforming growth factor-beta superfamily in mouse embryonic stem cell self-renewal.
Academic Article Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment.
Academic Article TGF-ß-superfamily signaling regulates embryonic stem cell heterogeneity: self-renewal as a dynamic and regulated equilibrium.
Academic Article Autocrine FGF feedback can establish distinct states of Nanog expression in pluripotent stem cells: a computational analysis.
Academic Article OVO-like 1 regulates progenitor cell fate in human trophoblast development.
Academic Article A Prolactin Family Paralog Regulates Placental Adaptations to a Physiological Stressor.
Academic Article Generation of Mitochondrial-nuclear eXchange Mice via Pronuclear Transfer.
Academic Article Origin of a rapidly evolving homeostatic control system programming testis function.
Academic Article Myogenin is required for late but not early aspects of myogenesis during mouse development.
Academic Article Periostin overexpression in collecting ducts accelerates renal cyst growth and fibrosis in polycystic kidney disease.
Academic Article Wild-type myoblasts rescue the ability of myogenin-null myoblasts to fuse in vivo.
Academic Article A hypomorphic myogenin allele reveals distinct myogenin expression levels required for viability, skeletal muscle development, and sternum formation.
Academic Article Temporal, spatial and tissue-specific expression of a myogenin-lacZ transgene targeted to the Hprt locus in mice.
Academic Article Thoracic skeletal defects in myogenin- and MRF4-deficient mice correlate with early defects in myotome and intercostal musculature.
Academic Article In Vivo Validation of CRISPR Reagents in Preimplantation Mouse Embryos.
Academic Article An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N- nitrosourea-mutagenized mouse embryonic stem cells.
Academic Article Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis.
Academic Article Gene-based chemical mutagenesis in mouse embryonic stem cells.
Academic Article Global growth deficiencies in mice lacking the ribosomal protein HIP/RPL29.
Academic Article Activation of the VEGFR1 chromatin domain: an angiogenic signal-ETS1/HIF-2alpha regulatory axis.
Academic Article Nodal signaling regulates the bone morphogenic protein pluripotency pathway in mouse embryonic stem cells.
Academic Article Early mammalian erythropoiesis requires the Dot1L methyltransferase.
Grant Hippo Signaling Effector and Placentation
Academic Article Primitive Erythropoiesis in the Mouse is Independent of DOT1L Methyltransferase Activity.
Academic Article DOT1L Methyltransferase Regulates Calcium Influx in Erythroid Progenitor Cells in Response to Erythropoietin.
Academic Article Expression of active B-Raf proto-oncogene in kidney collecting ducts induces cyst formation in normal mice and accelerates cyst growth in mice with polycystic kidney disease.

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