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Search Results to Francesco De Luca

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research overview Dr. De Luca's main research interest has been study of the molecular mechanisms governing longitudinal bone growth and, in turn, statural growth. Most of his research findings,obtained in vitro and in whole animal models,have elucidated the function of many paracrine (local) factors expressed in the cartilaginous growth plate of the long bones. These factors modulate growth plate chondrocyte proliferation and hypertrophy/differentiation, which are the main cellular events responsible for bone elongation. Another research interest of Dr. De Luca's is the study of the metabolic derangements associated with pediatric obesity. Specifically, his research group focused its attention especially on less known aspects of insulin resistance in children, such as sleep disorders, pre-hypertension, and oxidative stress. He is currently contributing to a number of research projects led by other faculty in his division on the efficacy and safety of metformin in children with a high risk to develop metabolic syndrome and type 2 diabetes.

One or more keywords matched the following items that are connected to De Luca, Francesco

Item TypeName
Concept Growth Plate
Academic Article Effects of Ca2+ sensing receptor activation in the growth plate.
Academic Article Role of cholesterol in the regulation of growth plate chondrogenesis and longitudinal bone growth.
Academic Article Effects of valproic acid on longitudinal bone growth.
Academic Article Endocrine regulation of the growth plate.
Academic Article Stanniocalcin 1 acts as a paracrine regulator of growth plate chondrogenesis.
Academic Article Impaired growth plate chondrogenesis in children with chronic illnesses.
Academic Article Inhibition of the proteasomal function in chondrocytes down-regulates growth plate chondrogenesis and longitudinal bone growth.
Academic Article Nuclear factor-kappaB p65 facilitates longitudinal bone growth by inducing growth plate chondrocyte proliferation and differentiation and by preventing apoptosis.
Academic Article Stimulatory effects of insulin-like growth factor-I on growth plate chondrogenesis are mediated by nuclear factor-kappaB p65.
Academic Article Insulin resistance secondary to a high-fat diet stimulates longitudinal bone growth and growth plate chondrogenesis in mice.
Academic Article Nuclear factor-kappaB (NF-kappaB) p65 interacts with Stat5b in growth plate chondrocytes and mediates the effects of growth hormone on chondrogenesis and on the expression of insulin-like growth factor-1 and bone morphogenetic protein-2.
Academic Article Role of fibroblast growth factor 21 (FGF21) in undernutrition-related attenuation of growth in mice.
Academic Article Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate.
Academic Article Insulin-Like Growth Factor-Independent Effects of Growth Hormone on Growth Plate Chondrogenesis and Longitudinal Bone Growth.
Academic Article Short and tall stature: a new paradigm emerges.
Academic Article Role of Nuclear Factor Kappa B (NF-?B) in Growth Plate Chondrogenesis.
Academic Article Regulatory Role for Growth Hormone in Statural Growth: IGF-Dependent and IGF-Independent Effects on Growth Plate Chondrogenesis and Longitudinal Bone Growth.
Academic Article The effect of a high-calorie diet on bone growth is mediated by the insulin receptor.
Academic Article In: Lavin N, ed. Manual of Endocrinology and Metabolism, 5th edition. Lippincott Manual Series. 2019.
Academic Article Regulatory role of NF-?B in growth plate chondrogenesis and its functional interaction with Growth Hormone.
Academic Article Withdrawal: Nuclear factor-?B p65 facilitates longitudinal bone growth by inducing growth plate chondrocyte proliferation and differentiation and by preventing apoptosis.

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