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De Luca, Francesco

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Dr. De Luca's main research interest has been study of the molecular mechanisms governing longitudinal bone growth and, in turn, statural growth. Most of his research findings,obtained in vitro and in whole animal models,have elucidated the function of many paracrine (local) factors expressed in the cartilaginous growth plate of the long bones. These factors modulate growth plate chondrocyte proliferation and hypertrophy/differentiation, which are the main cellular events responsible for bone elongation. Another research interest of Dr. De Luca's is the study of the metabolic derangements associated with pediatric obesity. Specifically, his research group focused its attention especially on less known aspects of insulin resistance in children, such as sleep disorders, pre-hypertension, and oxidative stress. He is currently contributing to a number of research projects led by other faculty in his division on the efficacy and safety of metformin in children with a high risk to develop metabolic syndrome and type 2 diabetes.

One or more keywords matched the following items that are connected to De Luca, Francesco

Item Type	Name
Concept	Bone Development
Academic Article	Role of cholesterol in the regulation of growth plate chondrogenesis and longitudinal bone growth.
Academic Article	Effects of valproic acid on longitudinal bone growth.
Academic Article	Endocrine regulation of the growth plate.
Academic Article	Stanniocalcin 1 acts as a paracrine regulator of growth plate chondrogenesis.
Academic Article	Impaired growth plate chondrogenesis in children with chronic illnesses.
Academic Article	Inhibition of the proteasomal function in chondrocytes down-regulates growth plate chondrogenesis and longitudinal bone growth.
Academic Article	Nuclear factor-kappaB p65 facilitates longitudinal bone growth by inducing growth plate chondrocyte proliferation and differentiation and by preventing apoptosis.
Academic Article	Insulin resistance secondary to a high-fat diet stimulates longitudinal bone growth and growth plate chondrogenesis in mice.
Academic Article	Insulin-Like Growth Factor-Independent Effects of Growth Hormone on Growth Plate Chondrogenesis and Longitudinal Bone Growth.
Academic Article	Role of Fibroblast Growth Factor 21 (FGF21) in the Regulation of Statural Growth.
Academic Article	Role of Nuclear Factor Kappa B (NF-?B) in Growth Plate Chondrogenesis.
Academic Article	Effect of Nutrition on Statural Growth?.
Academic Article	Regulatory Role for Growth Hormone in Statural Growth: IGF-Dependent and IGF-Independent Effects on Growth Plate Chondrogenesis and Longitudinal Bone Growth.
Academic Article	The effect of a high-calorie diet on bone growth is mediated by the insulin receptor.
Academic Article	Relationships between osteoprotegerin (OPG), receptor activator of nuclear factor kappaB ligand (RANKL), and growth hormone (GH) secretory status in short children.
Academic Article	Bicalutamide plus anastrozole for the treatment of gonadotropin-independent precocious puberty in boys with testotoxicosis: a phase II, open-label pilot study (BATT).
Academic Article	Regulatory role of NF-?B in growth plate chondrogenesis and its functional interaction with Growth Hormone.
Academic Article	Withdrawal: Nuclear factor-?B p65 facilitates longitudinal bone growth by inducing growth plate chondrocyte proliferation and differentiation and by preventing apoptosis.

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Bone Development