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Farooqi, Midhat

One or more keywords matched the following properties of Farooqi, Midhat

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Pediatric Cancer

research overview

As a molecular pathologist, Dr. Farooqi interprets clinical genetic testing results for both pediatric and adult patients in the setting of inherited disease and oncology, including whole exome sequencing and tumor somatic profiling. His clinical interests involve the development of new clinical diagnostic tests, especially for pediatric oncology. His research interests include epigenetic profiling and single cell sequencing of pediatric liquid and solid tumors. Dr. Farooqi works closely with Dr. Erin Guest and other researchers at the Genomic Medicine Center (GMC). The scientists in the GMC have extensive experience in all aspects of sequencing and have supported two clinical trials studying leukemia in children and infants—T2016-003 and AALL0631—by performing and analyzing whole genome, whole exome, bulk RNA, whole genome bisulfite, single cell, and long read sequencing of patient samples in collaboration with Johns Hopkins University and the Children's Hospital of Philadelphia. The research team will be performing similar work for two current trials: AALL15P1 (studying infant leukemia) and NCT02789228 (studying multi-antigen specific lymphocytes for the treatment of pediatric solid tumors); Dr. Farooqi is the Principal Investigator for the sequencing project supporting NCT02789228. He is also the Principal Investigator for a grant from the National Cancer Institute centered around sequence data sharing from pediatric tumors in support of the nationwide Childhood Cancer Data Initiative. Dr. Farooqi looks forward to additional collaborative sequencing projects, especially in the areas of pediatric oncology and cancer immunotherapy.

One or more keywords matched the following items that are connected to Farooqi, Midhat

Item Type	Name
Concept	Brain Neoplasms
Concept	DNA, Neoplasm
Concept	Neoplasm Recurrence, Local
Concept	Odontogenic Tumors
Concept	Paranasal Sinus Neoplasms
Concept	Skin Neoplasms
Concept	Biomarkers, Tumor
Concept	Central Nervous System Neoplasms
Concept	Skull Base Neoplasms
Concept	Tumor Suppressor Proteins
Academic Article	Precision Medicine in Pediatric Cancer: Current Applications and Future Prospects.
Academic Article	Validation of a next-generation sequencing oncology panel optimized for low input DNA.
Academic Article	Outcomes of Hematopoietic Cell Transplantation in Patients with Germline SAMD9/SAMD9L Mutations.
Academic Article	Next-Generation Sequencing in the Diagnosis of Rare Pediatric Sinonasal Tumors.
Academic Article	Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study.
Academic Article	Role of high-throughput sequencing in the diagnosis of cutaneous T-cell lymphoma.
Grant	Targeting Solid Tumors with Multi-antigen Specific T cells by Identifying the Genetic and Epigenetic Determinants of Therapeutic Response
Academic Article	Clinical Validation of Somatic Mutation Detection by the OncoScan CNV Plus Assay.
Grant	The Genomic and Cellular Landscape in Children and Young Adults with Sarcoma
Grant	Free the Data: Open Sharing of Comprehensive Genomic Childhood Cancer Datasets
Academic Article	Polycythemia vera in a 2-year-old child with a JAK2 exon 12 deletion.
Academic Article	MYOD1 as a prognostic indicator in rhabdomyosarcoma.
Academic Article	NanoString Digital Molecular Profiling of Protein and microRNA in Rhabdomyosarcoma.
Academic Article	Genetic heterogeneity and enrichment of variants in DNA-repair genes in ameloblastoma.
Academic Article	Integrated genetic profiling of archival pediatric high-grade glial tumors and reassessment with 2021 WHO classification of paediatric CNS tumours.
Academic Article	Perinucleolar Compartment (PNC) Prevalence as an Independent Prognostic Factor in Pediatric Ewing Sarcoma: A Multi-Institutional Study.
Academic Article	ROS1 Alterations as a Potential Driver of Gliomas in Infant, Pediatric, and Adult Patients.
Academic Article	Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors-A prospective study and guidelines for clinical testing.
Academic Article	Polypyrimidine Tract Binding Protein: A Universal Player in Cancer Development.

Search Criteria

Neoplasms