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research overview The focus in the lab is to understand the why and the how behind neonates developing diseases, with the goal of preventing/curing them. The lab starts with disease phenotypes and study the pathogenic mechanisms underlying disease evolution to guide the development of novel future therapies. The phenotypes of interest are necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), and rare infectious diseases such as herpes simplex virus (HSV) and Group B Streptococcus (GBS). The major challenge is that diseases in neonates and premature infants occupy a unique niche, wherein, injury to the host caused by noxious stimuli such as oxygen toxicity and bacteria occur during critical ontogenic windows. Therefore, disease pathogenesis needs to be examined in the context of developmental processes to decipher mechanism and test potential therapy. The lab uses human genomic studies, rodent pre-clinical models, cell culture studies, and bioinformatics to investigate the mechanisms and sub-phenotype neonatal diseases. The long-term goal is to build an internationally renowned program in neonatal research by integrating the skill sets of a diverse team of motivated scientists and collaborators. The lab uses knowledge obtained through the investigations to develop precision tools for identifying infants at risk of disease and develop novel treatment strategies to prevent or cure disease. The three major areas of research interest are: I. Lung and BPD Research: Bronchopulmonary dysplasia (BPD) is a debilitating chronic lung disease in premature infants. An area of emphasis is understanding the role of lung endothelial cell (EC) injury/reprogramming in impaired lung and vascular development in BPD. To address this issue, the lab has developed new pre-clinical models of disease, and several transgenic lines to identify the key molecular players that regulate normal and abnormal vascular development. A second challenge is the inability to discern BPD sub-phenotypes, at a genomic and functional level. The lab is addressing this challenge by performing genetic and deep phenotypic characterization in BPD infants. II. Necrotizing Enterocolitis Research: Necrotizing enterocolitis is a major cause of mortality in premature infants, and represents phenotypes for deviant host-microbiome interactions in the gut. The lab uses forward- and reverse genetics, microbiota studies, and host-bacteria interaction studies to investigate NEC. The immediate focus of this research is the gene, Single Immunoglobulin Interleukin-1 Related Receptor (SIGIRR), which the lab identified as a putative locus for NEC susceptibility. Using novel transgenic mice that encode a NEC-associated genetic mutation the lab discovered and the lab investigated the pathogenesis of NEC. They are also testing several therapies in the pre-clinical and in vivo models. III. Genetic Basis of Neonatal Disease Susceptibility: The team is one of the leaders in the field of neonatal genomics. The team used low throughput-based single gene or pathway approaches, and are initiating high throughput genome-wide approaches. Apart from complex phenotypes such as BPD and NEC, they are vested in unraveling the genetic basis of rare infectious disease phenotypes such as herpes simplex virus (HSV) and Group B Streptococcus (GBS). They are also initiating deep phenotyping and transcriptome analysis for complex phenotypes, which in combination with genetics, will help sub-classify complex phenotypes. These combined approaches can spur discovery approaches based on mechanism, as well as outcomes research based on interventions.

One or more keywords matched the following items that are connected to Sampath, Venkatesh

Item TypeName
Concept Infant
Concept Infant, Low Birth Weight
Concept Infant, Newborn
Concept Infant, Newborn, Diseases
Concept Infant, Premature
Concept Infant, Premature, Diseases
Concept Infant, Very Low Birth Weight
Concept Infant Formula
Concept Infant, Extremely Low Birth Weight
Concept Infant, Extremely Premature
Academic Article Risk factors for adverse neurodevelopment in extremely low birth weight infants with normal neonatal cranial ultrasound.
Academic Article Nonimmune hydrops fetalis and fulminant fatal disease due to congenital cytomegalovirus infection in a premature infant.
Academic Article Attenuation of lipopolysaccharide-induced oxidative stress and apoptosis in fetal pulmonary artery endothelial cells by hypoxia.
Academic Article The NFKB1 (g.-24519delATTG) variant is associated with necrotizing enterocolitis (NEC) in premature infants.
Academic Article A TLR5 (g.1174C?>?T) variant that encodes a stop codon (R392X) is associated with bronchopulmonary dysplasia.
Academic Article A TIR domain receptor-associated protein (TIRAP) variant SNP (rs8177374) confers protection against premature birth.
Academic Article Toll-like receptor genetic variants are associated with Gram-negative infections in VLBW infants.
Academic Article Antioxidant response genes sequence variants and BPD susceptibility in VLBW infants.
Academic Article SIGIRR genetic variants in premature infants with necrotizing enterocolitis.
Academic Article A toll-like receptor 9 (rs352140) variant is associated with placental inflammation in newborn infants.
Academic Article Necrotizing Enterocolitis Is Not Associated With Sequence Variants in Antioxidant Response Genes in Premature Infants.
Academic Article Genetic alterations in necrotizing enterocolitis.
Academic Article A functional ATG16L1 (T300A) variant is associated with necrotizing enterocolitis in premature infants.
Academic Article Prospective Comparison of Enfamil and Similac Liquid Human Milk Fortifier on Clinical Outcomes in Premature Infants.
Academic Article A Potential Role for the NOD1 Variant (rs6958571) in Gram-Positive Blood Stream Infection in ELBW Infants.
Academic Article Continuous pulse oximetry and respiratory rate trends predict short-term respiratory and growth outcomes in premature infants.
Academic Article Genetic predisposition to necrotizing enterocolitis in premature infants: Current knowledge, challenges, and future directions.
Academic Article Stem cell therapy for preventing neonatal diseases in the 21st century: Current understanding and challenges.
Academic Article Extended course of prednisolone in infants with severe bronchopulmonary dysplasia.
Academic Article Continuous vital sign analysis for predicting and preventing neonatal diseases in the twenty-first century: big data to the forefront.
Grant Single Immunoglobulin Interleukin-1 Related Receptor and necrotizing enterocolitis in premature infants
Grant Lipopolysaccharide-mediated oxidative stress and pulmonary vascular injury in Bro
Grant Inflammatory Angiogenesis in the Lung
Grant Developmental Immunotoxicity of PAH in premature infants
Grant ITGB2 immune genetic variants and NEC in premature infants
Grant TLRs-modulators of environmental lung injury in premature infants
Grant SIGIRR mutations and pathogenesis of NEC in premature infants
Grant ITGB2 genetic variants and NEC susceptibility in premature infants
Academic Article Fungal cutaneous microbiome and host determinants in preterm and term neonates.
Academic Article NEC-like intestinal injury is ameliorated by Lactobacillus rhamnosus GG in parallel with SIGIRR and A20 induction in neonatal mice.
Academic Article Impact of Maternal HbA1c Levels =6% and Race in Nondiabetic Pregnancies on Birthweight and Early Neonatal Hypoglycemia.
Academic Article ITGB2 (Integrin ß2) Immunomodulatory Gene Variants in Premature Infants With Necrotizing Enterocolitis.
Academic Article Challenges in diagnosing necrotizing enterocolitis.
Academic Article Respiratory, growth, and survival outcomes of infants with tracheostomy and ventilator dependence.
Academic Article Rare Genetic Variants in Immune Genes and Neonatal Herpes Simplex Viral Infections.
Academic Article Dynamics of the preterm gut microbiome in health and disease.
Academic Article Impact of opioid maintenance treatment during pregnancy on neonatal birth weight and head circumference.
Academic Article Angiopoietin-1 protects against endotoxin-induced neonatal lung injury and alveolar simplification in mice.
Academic Article Postnatal Sepsis and Bronchopulmonary Dysplasia in Premature Infants: Mechanistic Insights into "New BPD".
Academic Article EPHB4 Mutation Suppresses PROX1 Expression and Disrupts Lymphatic Development in Neonatal Hydrops.
Grant A Safer Glucocorticoid to Treat Neonatal Lung Injury with Limited Adverse Neurologic Effects
Academic Article Effect of Various Preterm Infant Milk Formulas on NEC-Like Gut Injury in Mice.

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