Loading...
Keywords
Last Name
Institution

Connection

Search Results to Tom Curran

This is a "connection" page, showing the details of why an item matched the keywords from your search.

                     
                     

One or more keywords matched the following properties of Curran, Tom

PropertyValue
research overview From 1984-1995, Dr. Curran worked at the Roche Institute of Molecular Biology ultimately rising to the position of Associate Director. He then founded the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital where he grew the Translational Brain Tumor Program over the period 1995-2006. He served as Deputy Scientific Director of the Children’s Hospital of Philadelphia Research Institute from 2006-2015 and he established the multi-institution Children’s Brain Tumor Tissue Consortium. Dr. Curran’s research spans the fields of cancer, signal transduction and neurobiology. He discovered and characterized the inducible Fos-Jun oncogenic transcription factor complex and demonstrated its function in diverse signal transduction processes. He also identified reelin, the gene responsible for the classic ataxic mouse mutation, reeler, and determined its role in the control of neuronal migration in the developing brain. Over the course of the last two decades, he pioneered the preclinical analysis of Hedgehog Pathway inhibitors for the treatment of pediatric medulloblastoma and transitioned this work into successful Phase I/II human clinical trials. His worked is published in over 298 papers that have been cited more than 72,000 times (Google Scholar). Dr. Curran was President of the American Association for Cancer Research (AACR) in 2000-2001 and he served on the National Cancer Institute Board of Scientific Advisors from 2000-2005. He was elected as a fellow of the American Association for the Advancement of Science (1994), the American Society of Microbiology (1994), the Royal Society, London (2005), the National Academy of Medicine (2009), the American Academy of Arts and Sciences (2012) and the Academy of the American Association for Cancer Research (2013). Dr. Curran has received several awards and honors including, the Passano Foundation Young Scientist Award in 1992, the Outstanding Achievement in Cancer Research award from the AACR in 1993, the Golgi Award from the Camillo Golgi Foundation and the Italian Academy of Neurosciences in 1994 and the Fred Epstein Lifetime Achievement Award from the Children's Brain Tumor Foundation in 2015. Many of his more than 50 trainees now hold senior positions in Academia and Industry.

One or more keywords matched the following items that are connected to Curran, Tom

Item TypeName
Concept Transcription Factor AP-1
Concept Activating Transcription Factor 2
Concept MSX1 Transcription Factor
Academic Article Cysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA binding.
Academic Article Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.
Academic Article Fos-Jun heterodimers and Jun homodimers bend DNA in opposite orientations: implications for transcription factor cooperativity.
Academic Article The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes.
Academic Article Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure.
Academic Article Common DNA binding site for Fos protein complexes and transcription factor AP-1.
Academic Article Use of fluorescence resonance energy transfer to estimate intramolecular distances in the Msx-1 homeodomain.
Academic Article Fos: an immediate-early transcription factor in neurons.
Academic Article Kainic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats.
Academic Article Transcription. Zen and the art of Fos and Jun.
Academic Article Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements.
Academic Article Design of a "minimAl" homeodomain: the N-terminal arm modulates DNA binding affinity and stabilizes homeodomain structure.
Academic Article A central role for Fos in human B- and T-cell NFAT (nuclear factor of activated T cells): an acidic region is required for in vitro assembly.
Academic Article Isolation of the cyclosporin-sensitive T cell transcription factor NFATp.
Academic Article The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun.
Academic Article Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF.
Academic Article An enhanced immune response in mice lacking the transcription factor NFAT1.
Academic Article Redox regulation of AP-1: a link between transcription factor signaling and DNA repair.

Search Criteria
  • Transcription Factor 3