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Search Results to Tom Curran

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One or more keywords matched the following items that are connected to Curran, Tom

Item TypeName
Concept Blood Proteins
Concept Calmodulin-Binding Proteins
Concept Chromosomal Proteins, Non-Histone
Concept Cytoskeletal Proteins
Concept DNA-Binding Proteins
Concept Eye Proteins
Concept Fungal Proteins
Concept Intermediate Filament Proteins
Concept Luminescent Proteins
Concept Membrane Proteins
Concept Microtubule-Associated Proteins
Concept Muscle Proteins
Concept Neoplasm Proteins
Concept Nerve Tissue Proteins
Concept Nuclear Proteins
Concept Oncogene Proteins, Viral
Concept Proteins
Concept Proto-Oncogene Proteins
Concept Recombinant Fusion Proteins
Concept Recombinant Proteins
Concept Repressor Proteins
Concept Retroviridae Proteins
Concept Viral Proteins
Concept Oncogene Proteins
Concept Proto-Oncogene Proteins c-myc
Concept Proto-Oncogene Proteins p21(ras)
Concept Extracellular Matrix Proteins
Concept Proto-Oncogene Proteins c-jun
Concept Proto-Oncogene Proteins c-fos
Concept Oncogene Proteins v-fos
Concept Immediate-Early Proteins
Concept Homeodomain Proteins
Concept Cell Cycle Proteins
Concept Proto-Oncogene Proteins c-bcl-2
Concept GTPase-Activating Proteins
Concept CCAAT-Enhancer-Binding Proteins
Concept Tumor Suppressor Proteins
Concept LDL-Receptor Related Proteins
Concept Saccharomyces cerevisiae Proteins
Concept Escherichia coli Proteins
Concept Adaptor Proteins, Vesicular Transport
Concept Intracellular Signaling Peptides and Proteins
Concept Adaptor Proteins, Signal Transducing
Concept Green Fluorescent Proteins
Concept Proto-Oncogene Proteins c-crk
Concept Apoptosis Regulatory Proteins
Concept Proto-Oncogene Proteins c-akt
Concept Proto-Oncogene Proteins c-maf
Concept Hedgehog Proteins
Concept GPI-Linked Proteins
Academic Article Fibroblast Growth Requires CT10 Regulator of Kinase (Crk) and Crk-like (CrkL).
Academic Article Reproducibility of academic preclinical translational research: lessons from the development of Hedgehog pathway inhibitors to treat cancer.
Academic Article Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma.
Academic Article Crk proteins transduce FGF signaling to promote lens fiber cell elongation.
Academic Article Astrocytes Promote Medulloblastoma Progression through Hedgehog Secretion.
Academic Article Nestin Mediates Hedgehog Pathway Tumorigenesis.
Academic Article CRK proteins selectively regulate T cell migration into inflamed tissues.
Academic Article Crk and CrkL are required for cell transformation by v-fos and v-ras.
Academic Article Neurobiology: Reelin mediates form and function.
Academic Article Dendritic planarity of Purkinje cells is independent of Reelin signaling.
Academic Article Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis.
Academic Article Essential roles of Crk and CrkL in fibroblast structure and motility.
Academic Article Yayoi era mutation disrupts brain and muscle.
Academic Article Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse.
Academic Article Absence of thyroid hormone receptor beta-retinoid X receptor interactions in auditory function and in the pituitary-thyroid axis.
Academic Article A gene expression approach to mapping the functional maturation of the hippocampus.
Academic Article Role of DNA 5-methylcytosine transferase in cell transformation by fos.
Academic Article Reelin regulates the development and synaptogenesis of the layer-specific entorhino-hippocampal connections.
Academic Article Gene dosage in mice--BAC to the future.
Academic Article Thyroid hormone regulates reelin and dab1 expression during brain development.
Academic Article Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1.
Academic Article Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS.
Academic Article Reelin is a ligand for lipoprotein receptors.
Academic Article The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched.
Academic Article Cortical development: Cdk5 gets into sticky situations.
Academic Article Reelin mRNA expression during embryonic brain development in the chick.
Academic Article Disabled-1 is expressed in type AII amacrine cells in the mouse retina.
Academic Article Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.
Academic Article Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1.
Academic Article Role of the reelin signaling pathway in central nervous system development.
Academic Article The reelin pathway modulates the structure and function of retinal synaptic circuitry.
Academic Article Disabled-1 interacts with a novel developmentally regulated protocadherin.
Academic Article Brain development: integrins and the Reelin pathway.
Academic Article Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice.
Academic Article Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling.
Academic Article ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease.
Academic Article mPPP1R16B is a novel mouse protein phosphatase 1 targeting subunit whose mRNA is located in cell bodies and dendrites of neurons in four distinct regions of the brain.
Academic Article Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1.
Academic Article Cysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA binding.
Academic Article Reovirus prolongs survival and reduces the frequency of spinal and leptomeningeal metastases from medulloblastoma.
Academic Article Crystal structures of the Dab homology domains of mouse disabled 1 and 2.
Academic Article Interaction of Disabled-1 and the GTPase activating protein Dab2IP in mouse brain.
Academic Article Differential binding of ligands to the apolipoprotein E receptor 2.
Academic Article Components of the reelin signaling pathway are expressed in the spinal cord.
Academic Article Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins.
Academic Article Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.
Academic Article Gli1 is important for medulloblastoma formation in Ptc1+/- mice.
Academic Article A transcriptome map of cellular transformation by the fos oncogene.
Academic Article Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics.
Academic Article The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation.
Academic Article Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies.
Academic Article The hedgehog pathway and neurological disorders.
Academic Article Cardiovascular and craniofacial defects in Crk-null mice.
Academic Article Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor.
Academic Article Loss of suppressor-of-fused function promotes tumorigenesis.
Academic Article Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality.
Academic Article Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure.
Academic Article Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling.
Academic Article Cancer: Hedgehog's other great trick.
Academic Article Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway.
Academic Article Ectopic expression of reelin alters migration of sympathetic preganglionic neurons in the spinal cord.
Academic Article Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor.
Academic Article Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L.
Academic Article The genetic landscape of the childhood cancer medulloblastoma.
Academic Article PTHrP treatment fails to rescue bone defects caused by Hedgehog pathway inhibition in young mice.
Academic Article The Hedgehog's tale: developing strategies for targeting cancer.
Academic Article The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress.
Academic Article Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease.
Academic Article Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity.
Academic Article Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome.
Academic Article Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.
Academic Article The Ketogenic Diet Does Not Affect Growth of Hedgehog Pathway Medulloblastoma in Mice.
Academic Article Generation of a mouse model of atypical teratoid/rhabdoid tumor of the central nervous system through combined deletion of Snf5 and p53.
Academic Article Whole-exome identifies RXRG and TH germline variants in familial isolated prolactinoma.
Academic Article Fos and Jun: oncogenic transcription factors.
Academic Article Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts.
Academic Article Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.
Academic Article Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.
Academic Article Regulation of a fos-lacZ fusion gene: a paradigm for quantitative analysis of stimulus-transcription coupling.
Academic Article Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase.
Academic Article fos-lacZ transgenic mice: mapping sites of gene induction in the central nervous system.
Academic Article Fos is phosphorylated by p34cdc2, cAMP-dependent protein kinase and protein kinase C at multiple sites clustered within regulatory regions.
Academic Article Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.
Academic Article Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.
Academic Article Transcriptional regulation by Fos and Jun in vitro: interaction among multiple activator and regulatory domains.
Academic Article Fos-Jun heterodimers and Jun homodimers bend DNA in opposite orientations: implications for transcription factor cooperativity.
Academic Article Fosvergn├╝gen. The excitement of immediate-early genes.
Academic Article Inhibition of jun transformation by a mutated fos gene: design of an anti-oncogene.
Academic Article DNA bending by Fos and Jun: the flexible hinge model.
Academic Article Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly.
Academic Article Analysis of dimerization and DNA binding functions in Fos and Jun by domain-swapping: involvement of residues outside the leucine zipper/basic region.
Academic Article Transcriptional activation and repression by Fos are independent functions: the C terminus represses immediate-early gene expression via CArG elements.
Academic Article Induction of c-fos mRNA expression by afterdischarge in the hippocampus of naive and kindled rats.
Academic Article Redox regulation of fos and jun DNA-binding activity in vitro.
Academic Article Fos and jun cooperate in transcriptional regulation via heterologous activation domains.
Academic Article Altered protein conformation on DNA binding by Fos and Jun.
Academic Article Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription.
Academic Article A ubiquitous nuclear protein stimulates the DNA-binding activity of fos and jun indirectly.
Academic Article Inducible proto-oncogenes of the nervous system: their contribution to transcription factors and neuroplasticity.
Academic Article Inducible proto-oncogene transcription factors: third messengers in the brain?
Academic Article Encounters with Fos and Jun on the road to AP-1.
Academic Article Direct cloning of leucine zipper proteins: Jun binds cooperatively to the CRE with CRE-BP1.
Academic Article Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence.
Academic Article Barium modulates c-fos expression and post-translational modification.
Academic Article Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro.
Academic Article Stimulus-transcription coupling in neurons: role of cellular immediate-early genes.
Academic Article The carboxy terminus of the viral Jun oncoprotein is required for complex formation with the cellular Fos protein.
Academic Article Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains.
Academic Article The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes.
Academic Article Regulation of proenkephalin by Fos and Jun.
Academic Article Calcium and proto-oncogene involvement in the immediate-early response in the nervous system.
Academic Article Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure.
Academic Article The structure and function of the fos proto-oncogene.
Academic Article Glutamate receptor agonists increase the expression of Fos, Fra, and AP-1 DNA binding activity in the mammalian brain.
Academic Article The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites.
Academic Article Extended life span and tumorigenicity of nonestablished mouse connective tissue cells transformed by the fos oncogene of FBR-MuSV.
Academic Article Deletion of the gag region from FBR murine osteosarcoma virus does not affect its enhanced transforming activity.
Academic Article The fos gene product undergoes extensive post-translational modification in eukaryotic but not in prokaryotic cells.
Academic Article Mapping patterns of c-fos expression in the central nervous system after seizure.
Academic Article Beyond the second messenger: oncogenes and transcription factors.
Academic Article Microinjection of transforming ras protein induces c-fos expression.
Academic Article Memories of fos.
Academic Article Common DNA binding site for Fos protein complexes and transcription factor AP-1.
Academic Article A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization.
Academic Article Fos-associated protein p39 is the product of the jun proto-oncogene.
Academic Article Expression of c-fos protein in brain: metabolic mapping at the cellular level.
Academic Article fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen.
Academic Article Fos and Jun: the AP-1 connection.
Academic Article Calcium as a modulator of the immediate-early gene cascade in neurons.
Academic Article Activation of the transforming potential of the human fos proto-oncogene requires message stabilization and results in increased amounts of partially modified fos protein.
Academic Article Analysis of Fos protein complexes and Fos-related antigens by high-resolution two-dimensional gel electrophoresis.
Academic Article Isolation and characterization of the c-fos(rat) cDNA and analysis of post-translational modification in vitro.
Academic Article The Fos protein complex is associated with DNA in isolated nuclei and binds to DNA cellulose.
Academic Article Viral and cellular fos proteins are complexed with a 39,000-dalton cellular protein.
Academic Article FBR murine osteosarcoma virus. I. Molecular analysis and characterization of a 75,000-Da gag-fos fusion product.
Academic Article FBR murine osteosarcoma virus. II. Nucleotide sequence of the provirus reveals that the genome contains sequences acquired from two cellular genes.
Academic Article Identification of a 39,000-dalton protein in cells transformed by the FBJ murine osteosarcoma virus.
Academic Article Candidate product of the FBJ murine osteosarcoma virus oncogene: characterization of a 55,000-dalton phosphoprotein.
Academic Article Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini.
Academic Article Viral and cellular fos proteins: a comparative analysis.
Academic Article Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein.
Academic Article c-fos protein can induce cellular transformation: a novel mechanism of activation of a cellular oncogene.
Academic Article The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains.
Academic Article Transcription factors as molecular mediators in cell death.
Academic Article Reeler gene discrepancies.
Academic Article Use of fluorescence resonance energy transfer to estimate intramolecular distances in the Msx-1 homeodomain.
Academic Article Human genetics. Smart transcription factors.
Academic Article Apoptosis in the nervous system: new revelations.
Academic Article A protein related to extracellular matrix proteins deleted in the mouse mutant reeler.
Academic Article Fos: an immediate-early transcription factor in neurons.
Academic Article Kainic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats.
Academic Article Analysis of c-Fos and c-Jun redox-dependent DNA binding activity.
Academic Article Transcription. Zen and the art of Fos and Jun.
Academic Article Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements.
Academic Article Design of a "minimAl" homeodomain: the N-terminal arm modulates DNA binding affinity and stabilizes homeodomain structure.
Academic Article A central role for Fos in human B- and T-cell NFAT (nuclear factor of activated T cells): an acidic region is required for in vitro assembly.
Academic Article A conserved region adjacent to the basic domain is required for recognition of an extended DNA binding site by Maf/Nrl family proteins.
Academic Article Energy transfer analysis of Fos-Jun dimerization and DNA binding.
Academic Article Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia.
Academic Article Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun.
Academic Article Cell transformation by c-fos requires an extended period of expression and is independent of the cell cycle.
Academic Article Isolation of the cyclosporin-sensitive T cell transcription factor NFATp.
Academic Article Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region.
Academic Article Differential roles for Fos and Jun in DNA-binding: redox-dependent and independent functions.
Academic Article Dimerization and DNA binding alter phosphorylation of Fos and Jun.
Academic Article Selective DNA bending by a variety of bZIP proteins.
Academic Article The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun.
Academic Article The regulation of c-fos: too much is never enough.
Academic Article Escape from redox regulation enhances the transforming activity of Fos.
Academic Article Continuous c-fos expression precedes programmed cell death in vivo.
Academic Article Regulation of proto-oncogene expression in adult and developing lungs.
Academic Article Fos is a preferential target of glucocorticoid receptor inhibition of AP-1 activity in vitro.
Academic Article Ubiquitinylation of transcription factors c-Jun and c-Fos using reconstituted ubiquitinylating enzymes.
Academic Article Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF.
Academic Article An enhanced immune response in mice lacking the transcription factor NFAT1.
Academic Article The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.
Academic Article Developmental expression of Fos-lacZ in the brains of postnatal transgenic rats.
Academic Article c-Jun stimulates origin-dependent DNA unwinding by polyomavirus large Tantigen.
Academic Article Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody.
Academic Article The human reelin gene: isolation, sequencing, and mapping on chromosome 7.
Academic Article Identification of redox/repair protein Ref-1 as a potent activator of p53.
Academic Article The transcription activation domains of Fos and Jun induce DNA bending through electrostatic interactions.
Academic Article Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice.
Academic Article Cerebellar disorganization characteristic of reeler in scrambler mutant mice despite presence of reelin.
Academic Article Reeler: new tales on an old mutant mouse.
Academic Article Role of reelin in the control of brain development.
Academic Article Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain.
Academic Article Leukotriene Synthesis Is Critical for Medulloblastoma Progression.
Academic Article Requirement for Crk and CrkL during postnatal lens development.
Academic Article Quantitative assessment of glioblastoma phenotypes in vitro establishes cell migration as a robust readout of Crk and CrkL activity.
Academic Article Statins repress hedgehog signaling in medulloblastoma with no bone toxicities.
Academic Article Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality.

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