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Search Results to Tom Curran

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Curran, Tom

One or more keywords matched the following items that are connected to Curran, Tom

Item Type	Name
Concept	Blood Proteins
Concept	Calmodulin-Binding Proteins
Concept	Chromosomal Proteins, Non-Histone
Concept	Cytoskeletal Proteins
Concept	DNA-Binding Proteins
Concept	Eye Proteins
Concept	Fungal Proteins
Concept	Intermediate Filament Proteins
Concept	Luminescent Proteins
Concept	Membrane Proteins
Concept	Microtubule-Associated Proteins
Concept	Muscle Proteins
Concept	Neoplasm Proteins
Concept	Nerve Tissue Proteins
Concept	Nuclear Proteins
Concept	Oncogene Proteins, Viral
Concept	Proteins
Concept	Proto-Oncogene Proteins
Concept	Recombinant Fusion Proteins
Concept	Recombinant Proteins
Concept	Repressor Proteins
Concept	Retroviridae Proteins
Concept	Viral Proteins
Concept	Oncogene Proteins
Concept	Proto-Oncogene Proteins c-myc
Concept	Proto-Oncogene Proteins p21(ras)
Concept	Extracellular Matrix Proteins
Concept	Proto-Oncogene Proteins c-jun
Concept	Proto-Oncogene Proteins c-fos
Concept	Oncogene Proteins v-fos
Concept	Immediate-Early Proteins
Concept	Homeodomain Proteins
Concept	Cell Cycle Proteins
Concept	Proto-Oncogene Proteins c-bcl-2
Concept	GTPase-Activating Proteins
Concept	CCAAT-Enhancer-Binding Proteins
Concept	Tumor Suppressor Proteins
Concept	LDL-Receptor Related Proteins
Concept	Saccharomyces cerevisiae Proteins
Concept	Escherichia coli Proteins
Concept	Adaptor Proteins, Vesicular Transport
Concept	Intracellular Signaling Peptides and Proteins
Concept	Adaptor Proteins, Signal Transducing
Concept	Green Fluorescent Proteins
Concept	Proto-Oncogene Proteins c-crk
Concept	Apoptosis Regulatory Proteins
Concept	Proto-Oncogene Proteins c-akt
Concept	Proto-Oncogene Proteins c-maf
Concept	Hedgehog Proteins
Concept	GPI-Linked Proteins
Academic Article	Fibroblast Growth Requires CT10 Regulator of Kinase (Crk) and Crk-like (CrkL).
Academic Article	Reproducibility of academic preclinical translational research: lessons from the development of Hedgehog pathway inhibitors to treat cancer.
Academic Article	Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma.
Academic Article	Crk proteins transduce FGF signaling to promote lens fiber cell elongation.
Academic Article	Astrocytes Promote Medulloblastoma Progression through Hedgehog Secretion.
Academic Article	Nestin Mediates Hedgehog Pathway Tumorigenesis.
Academic Article	CRK proteins selectively regulate T cell migration into inflamed tissues.
Academic Article	Crk and CrkL are required for cell transformation by v-fos and v-ras.
Academic Article	Neurobiology: Reelin mediates form and function.
Academic Article	Dendritic planarity of Purkinje cells is independent of Reelin signaling.
Academic Article	Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis.
Academic Article	Essential roles of Crk and CrkL in fibroblast structure and motility.
Academic Article	Yayoi era mutation disrupts brain and muscle.
Academic Article	Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse.
Academic Article	Absence of thyroid hormone receptor beta-retinoid X receptor interactions in auditory function and in the pituitary-thyroid axis.
Academic Article	A gene expression approach to mapping the functional maturation of the hippocampus.
Academic Article	Role of DNA 5-methylcytosine transferase in cell transformation by fos.
Academic Article	Reelin regulates the development and synaptogenesis of the layer-specific entorhino-hippocampal connections.
Academic Article	Gene dosage in mice--BAC to the future.
Academic Article	Thyroid hormone regulates reelin and dab1 expression during brain development.
Academic Article	Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1.
Academic Article	Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS.
Academic Article	Reelin is a ligand for lipoprotein receptors.
Academic Article	The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched.
Academic Article	Cortical development: Cdk5 gets into sticky situations.
Academic Article	Reelin mRNA expression during embryonic brain development in the chick.
Academic Article	Disabled-1 is expressed in type AII amacrine cells in the mouse retina.
Academic Article	Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.
Academic Article	Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1.
Academic Article	Role of the reelin signaling pathway in central nervous system development.
Academic Article	The reelin pathway modulates the structure and function of retinal synaptic circuitry.
Academic Article	Disabled-1 interacts with a novel developmentally regulated protocadherin.
Academic Article	Brain development: integrins and the Reelin pathway.
Academic Article	Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice.
Academic Article	Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling.
Academic Article	ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease.
Academic Article	mPPP1R16B is a novel mouse protein phosphatase 1 targeting subunit whose mRNA is located in cell bodies and dendrites of neurons in four distinct regions of the brain.
Academic Article	Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1.
Academic Article	Cysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA binding.
Academic Article	Reovirus prolongs survival and reduces the frequency of spinal and leptomeningeal metastases from medulloblastoma.
Academic Article	Crystal structures of the Dab homology domains of mouse disabled 1 and 2.
Academic Article	Interaction of Disabled-1 and the GTPase activating protein Dab2IP in mouse brain.
Academic Article	Differential binding of ligands to the apolipoprotein E receptor 2.
Academic Article	Components of the reelin signaling pathway are expressed in the spinal cord.
Academic Article	Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins.
Academic Article	Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.
Academic Article	Gli1 is important for medulloblastoma formation in Ptc1+/- mice.
Academic Article	A transcriptome map of cellular transformation by the fos oncogene.
Academic Article	Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics.
Academic Article	The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation.
Academic Article	Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies.
Academic Article	The hedgehog pathway and neurological disorders.
Academic Article	Cardiovascular and craniofacial defects in Crk-null mice.
Academic Article	Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor.
Academic Article	Loss of suppressor-of-fused function promotes tumorigenesis.
Academic Article	Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality.
Academic Article	Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure.
Academic Article	Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling.
Academic Article	Cancer: Hedgehog's other great trick.
Academic Article	Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway.
Academic Article	Ectopic expression of reelin alters migration of sympathetic preganglionic neurons in the spinal cord.
Academic Article	Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor.
Academic Article	Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L.
Academic Article	The genetic landscape of the childhood cancer medulloblastoma.
Academic Article	PTHrP treatment fails to rescue bone defects caused by Hedgehog pathway inhibition in young mice.
Academic Article	The Hedgehog's tale: developing strategies for targeting cancer.
Academic Article	The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress.
Academic Article	Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease.
Academic Article	Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity.
Academic Article	Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome.
Academic Article	Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.
Academic Article	The Ketogenic Diet Does Not Affect Growth of Hedgehog Pathway Medulloblastoma in Mice.
Academic Article	Generation of a mouse model of atypical teratoid/rhabdoid tumor of the central nervous system through combined deletion of Snf5 and p53.
Academic Article	Whole-exome identifies RXRG and TH germline variants in familial isolated prolactinoma.
Academic Article	Fos and Jun: oncogenic transcription factors.
Academic Article	Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts.
Academic Article	Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.
Academic Article	Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.
Academic Article	Regulation of a fos-lacZ fusion gene: a paradigm for quantitative analysis of stimulus-transcription coupling.
Academic Article	Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase.
Academic Article	fos-lacZ transgenic mice: mapping sites of gene induction in the central nervous system.
Academic Article	Fos is phosphorylated by p34cdc2, cAMP-dependent protein kinase and protein kinase C at multiple sites clustered within regulatory regions.
Academic Article	Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.
Academic Article	Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.
Academic Article	Transcriptional regulation by Fos and Jun in vitro: interaction among multiple activator and regulatory domains.
Academic Article	Fos-Jun heterodimers and Jun homodimers bend DNA in opposite orientations: implications for transcription factor cooperativity.
Academic Article	Fosvergnügen. The excitement of immediate-early genes.
Academic Article	Inhibition of jun transformation by a mutated fos gene: design of an anti-oncogene.
Academic Article	DNA bending by Fos and Jun: the flexible hinge model.
Academic Article	Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly.
Academic Article	Analysis of dimerization and DNA binding functions in Fos and Jun by domain-swapping: involvement of residues outside the leucine zipper/basic region.
Academic Article	Transcriptional activation and repression by Fos are independent functions: the C terminus represses immediate-early gene expression via CArG elements.
Academic Article	Induction of c-fos mRNA expression by afterdischarge in the hippocampus of naive and kindled rats.
Academic Article	Redox regulation of fos and jun DNA-binding activity in vitro.
Academic Article	Fos and jun cooperate in transcriptional regulation via heterologous activation domains.
Academic Article	Altered protein conformation on DNA binding by Fos and Jun.
Academic Article	Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription.
Academic Article	A ubiquitous nuclear protein stimulates the DNA-binding activity of fos and jun indirectly.
Academic Article	Inducible proto-oncogenes of the nervous system: their contribution to transcription factors and neuroplasticity.
Academic Article	Inducible proto-oncogene transcription factors: third messengers in the brain?
Academic Article	Encounters with Fos and Jun on the road to AP-1.
Academic Article	Direct cloning of leucine zipper proteins: Jun binds cooperatively to the CRE with CRE-BP1.
Academic Article	Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence.
Academic Article	Barium modulates c-fos expression and post-translational modification.
Academic Article	Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro.
Academic Article	Stimulus-transcription coupling in neurons: role of cellular immediate-early genes.
Academic Article	The carboxy terminus of the viral Jun oncoprotein is required for complex formation with the cellular Fos protein.
Academic Article	Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains.
Academic Article	The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes.
Academic Article	Regulation of proenkephalin by Fos and Jun.
Academic Article	Calcium and proto-oncogene involvement in the immediate-early response in the nervous system.
Academic Article	Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure.
Academic Article	The structure and function of the fos proto-oncogene.
Academic Article	Glutamate receptor agonists increase the expression of Fos, Fra, and AP-1 DNA binding activity in the mammalian brain.
Academic Article	The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites.
Academic Article	Extended life span and tumorigenicity of nonestablished mouse connective tissue cells transformed by the fos oncogene of FBR-MuSV.
Academic Article	Deletion of the gag region from FBR murine osteosarcoma virus does not affect its enhanced transforming activity.
Academic Article	The fos gene product undergoes extensive post-translational modification in eukaryotic but not in prokaryotic cells.
Academic Article	Mapping patterns of c-fos expression in the central nervous system after seizure.
Academic Article	Beyond the second messenger: oncogenes and transcription factors.
Academic Article	Microinjection of transforming ras protein induces c-fos expression.
Academic Article	Memories of fos.
Academic Article	Common DNA binding site for Fos protein complexes and transcription factor AP-1.
Academic Article	A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization.
Academic Article	Fos-associated protein p39 is the product of the jun proto-oncogene.
Academic Article	Expression of c-fos protein in brain: metabolic mapping at the cellular level.
Academic Article	fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen.
Academic Article	Fos and Jun: the AP-1 connection.
Academic Article	Calcium as a modulator of the immediate-early gene cascade in neurons.
Academic Article	Activation of the transforming potential of the human fos proto-oncogene requires message stabilization and results in increased amounts of partially modified fos protein.
Academic Article	Analysis of Fos protein complexes and Fos-related antigens by high-resolution two-dimensional gel electrophoresis.
Academic Article	Isolation and characterization of the c-fos(rat) cDNA and analysis of post-translational modification in vitro.
Academic Article	The Fos protein complex is associated with DNA in isolated nuclei and binds to DNA cellulose.
Academic Article	Viral and cellular fos proteins are complexed with a 39,000-dalton cellular protein.
Academic Article	FBR murine osteosarcoma virus. I. Molecular analysis and characterization of a 75,000-Da gag-fos fusion product.
Academic Article	FBR murine osteosarcoma virus. II. Nucleotide sequence of the provirus reveals that the genome contains sequences acquired from two cellular genes.
Academic Article	Identification of a 39,000-dalton protein in cells transformed by the FBJ murine osteosarcoma virus.
Academic Article	Candidate product of the FBJ murine osteosarcoma virus oncogene: characterization of a 55,000-dalton phosphoprotein.
Academic Article	Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini.
Academic Article	Viral and cellular fos proteins: a comparative analysis.
Academic Article	Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein.
Academic Article	c-fos protein can induce cellular transformation: a novel mechanism of activation of a cellular oncogene.
Academic Article	The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains.
Academic Article	Transcription factors as molecular mediators in cell death.
Academic Article	Reeler gene discrepancies.
Academic Article	Use of fluorescence resonance energy transfer to estimate intramolecular distances in the Msx-1 homeodomain.
Academic Article	Human genetics. Smart transcription factors.
Academic Article	Apoptosis in the nervous system: new revelations.
Academic Article	A protein related to extracellular matrix proteins deleted in the mouse mutant reeler.
Academic Article	Fos: an immediate-early transcription factor in neurons.
Academic Article	Kainic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats.
Academic Article	Analysis of c-Fos and c-Jun redox-dependent DNA binding activity.
Academic Article	Transcription. Zen and the art of Fos and Jun.
Academic Article	Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements.
Academic Article	Design of a "minimAl" homeodomain: the N-terminal arm modulates DNA binding affinity and stabilizes homeodomain structure.
Academic Article	A central role for Fos in human B- and T-cell NFAT (nuclear factor of activated T cells): an acidic region is required for in vitro assembly.
Academic Article	A conserved region adjacent to the basic domain is required for recognition of an extended DNA binding site by Maf/Nrl family proteins.
Academic Article	Energy transfer analysis of Fos-Jun dimerization and DNA binding.
Academic Article	Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia.
Academic Article	Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun.
Academic Article	Cell transformation by c-fos requires an extended period of expression and is independent of the cell cycle.
Academic Article	Isolation of the cyclosporin-sensitive T cell transcription factor NFATp.
Academic Article	Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region.
Academic Article	Differential roles for Fos and Jun in DNA-binding: redox-dependent and independent functions.
Academic Article	Dimerization and DNA binding alter phosphorylation of Fos and Jun.
Academic Article	Selective DNA bending by a variety of bZIP proteins.
Academic Article	The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun.
Academic Article	The regulation of c-fos: too much is never enough.
Academic Article	Escape from redox regulation enhances the transforming activity of Fos.
Academic Article	Continuous c-fos expression precedes programmed cell death in vivo.
Academic Article	Regulation of proto-oncogene expression in adult and developing lungs.
Academic Article	Fos is a preferential target of glucocorticoid receptor inhibition of AP-1 activity in vitro.
Academic Article	Ubiquitinylation of transcription factors c-Jun and c-Fos using reconstituted ubiquitinylating enzymes.
Academic Article	Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF.
Academic Article	An enhanced immune response in mice lacking the transcription factor NFAT1.
Academic Article	The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.
Academic Article	Developmental expression of Fos-lacZ in the brains of postnatal transgenic rats.
Academic Article	c-Jun stimulates origin-dependent DNA unwinding by polyomavirus large Tantigen.
Academic Article	Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody.
Academic Article	The human reelin gene: isolation, sequencing, and mapping on chromosome 7.
Academic Article	Identification of redox/repair protein Ref-1 as a potent activator of p53.
Academic Article	The transcription activation domains of Fos and Jun induce DNA bending through electrostatic interactions.
Academic Article	Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice.
Academic Article	Cerebellar disorganization characteristic of reeler in scrambler mutant mice despite presence of reelin.
Academic Article	Reeler: new tales on an old mutant mouse.
Academic Article	Role of reelin in the control of brain development.
Academic Article	Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain.
Academic Article	Leukotriene Synthesis Is Critical for Medulloblastoma Progression.
Academic Article	Requirement for Crk and CrkL during postnatal lens development.
Academic Article	Quantitative assessment of glioblastoma phenotypes in vitro establishes cell migration as a robust readout of Crk and CrkL activity.
Academic Article	Statins repress hedgehog signaling in medulloblastoma with no bone toxicities.
Academic Article	Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality.

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