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Search Results to Tom Curran

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One or more keywords matched the following properties of Curran, Tom

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research overview From 1984-1995, Dr. Curran worked at the Roche Institute of Molecular Biology ultimately rising to the position of Associate Director. He then founded the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital where he grew the Translational Brain Tumor Program over the period 1995-2006. He served as Deputy Scientific Director of the Children’s Hospital of Philadelphia Research Institute from 2006-2015 and he established the multi-institution Children’s Brain Tumor Tissue Consortium. Dr. Curran’s research spans the fields of cancer, signal transduction and neurobiology. He discovered and characterized the inducible Fos-Jun oncogenic transcription factor complex and demonstrated its function in diverse signal transduction processes. He also identified reelin, the gene responsible for the classic ataxic mouse mutation, reeler, and determined its role in the control of neuronal migration in the developing brain. Over the course of the last two decades, he pioneered the preclinical analysis of Hedgehog Pathway inhibitors for the treatment of pediatric medulloblastoma and transitioned this work into successful Phase I/II human clinical trials. His worked is published in over 290 papers that have been cited more than 50,000 times. Dr. Curran was President of the American Association for Cancer Research (AACR) in 2000-2001 and he served on the National Cancer Institute Board of Scientific Advisors from 2000-2005. He was elected as a fellow of the American Association for the Advancement of Science (1994), the American Society of Microbiology (1994), the Royal Society, London (2005), the National Academy of Medicine (2009), the American Academy of Arts and Sciences (2012) and the Academy of the American Association for Cancer Research (2013). Dr. Curran has received several awards and honors including, the Passano Foundation Young Scientist Award in 1992, the Outstanding Achievement in Cancer Research award from the AACR in 1993, the Golgi Award from the Camillo Golgi Foundation and the Italian Academy of Neurosciences in 1994 and the Fred Epstein Lifetime Achievement Award from the Children's Brain Tumor Foundation in 2015. Many of his more than 50 trainees now hold senior positions in Academia and Industry.

One or more keywords matched the following items that are connected to Curran, Tom

Item TypeName
Concept Mutation
Concept Point Mutation
Concept Germ-Line Mutation
Academic Article Yayoi era mutation disrupts brain and muscle.
Academic Article Dysfunctions in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R).
Academic Article The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched.
Academic Article Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.
Academic Article Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice.
Academic Article Cysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA binding.
Academic Article Crystal structures of the Dab homology domains of mouse disabled 1 and 2.
Academic Article Differential binding of ligands to the apolipoprotein E receptor 2.
Academic Article Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins.
Academic Article Gene expression profiles of mouse retinas during the second and third postnatal weeks.
Academic Article Patched2 modulates tumorigenesis in patched1 heterozygous mice.
Academic Article Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L.
Academic Article The genetic landscape of the childhood cancer medulloblastoma.
Academic Article The Hedgehog's tale: developing strategies for targeting cancer.
Academic Article The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress.
Academic Article Whole-exome identifies RXRG and TH germline variants in familial isolated prolactinoma.
Academic Article Crossed signals: oncogenic transcription factors.
Academic Article Transcriptional activation and repression by Fos are independent functions: the C terminus represses immediate-early gene expression via CArG elements.
Academic Article Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence.
Academic Article The carboxy terminus of the viral Jun oncoprotein is required for complex formation with the cellular Fos protein.
Academic Article Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains.
Academic Article Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene.
Academic Article Common DNA binding site for Fos protein complexes and transcription factor AP-1.
Academic Article N-terminal variants of thyroid hormone receptor beta: differential function and potential contribution to syndrome of resistance to thyroid hormone.
Academic Article Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements.
Academic Article Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun.
Academic Article Escape from redox regulation enhances the transforming activity of Fos.
Academic Article Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function.
Academic Article Thyroid hormone receptor beta is essential for development of auditory function.
Academic Article Genetic analysis of thyroid hormone receptors in development and disease.
Academic Article Detection of the reelin breakpoint in reeler mice.
Academic Article Identification of redox/repair protein Ref-1 as a potent activator of p53.
Academic Article Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice.

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