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Curran, Tom

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From 1984-1995, Dr. Curran worked at the Roche Institute of Molecular Biology ultimately rising to the position of Associate Director. He then founded the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital where he grew the Translational Brain Tumor Program over the period 1995-2006. He served as Deputy Scientific Director of the Children’s Hospital of Philadelphia Research Institute from 2006-2015 and he established the multi-institution Children’s Brain Tumor Tissue Consortium. Dr. Curran’s research spans the fields of cancer, signal transduction and neurobiology. He discovered and characterized the inducible Fos-Jun oncogenic transcription factor complex and demonstrated its function in diverse signal transduction processes. He also identified reelin, the gene responsible for the classic ataxic mouse mutation, reeler, and determined its role in the control of neuronal migration in the developing brain. Over the course of the last two decades, he pioneered the preclinical analysis of Hedgehog Pathway inhibitors for the treatment of pediatric medulloblastoma and transitioned this work into successful Phase I/II human clinical trials. His worked is published in over 290 papers that have been cited more than 50,000 times. Dr. Curran was President of the American Association for Cancer Research (AACR) in 2000-2001 and he served on the National Cancer Institute Board of Scientific Advisors from 2000-2005. He was elected as a fellow of the American Association for the Advancement of Science (1994), the American Society of Microbiology (1994), the Royal Society, London (2005), the National Academy of Medicine (2009), the American Academy of Arts and Sciences (2012) and the Academy of the American Association for Cancer Research (2013). Dr. Curran has received several awards and honors including, the Passano Foundation Young Scientist Award in 1992, the Outstanding Achievement in Cancer Research award from the AACR in 1993, the Golgi Award from the Camillo Golgi Foundation and the Italian Academy of Neurosciences in 1994 and the Fred Epstein Lifetime Achievement Award from the Children's Brain Tumor Foundation in 2015. Many of his more than 50 trainees now hold senior positions in Academia and Industry.

One or more keywords matched the following items that are connected to Curran, Tom

Item Type	Name
Concept	Mice, Inbred BALB C
Concept	Mice, Inbred C3H
Concept	Mice, Inbred C57BL
Concept	Mice, Inbred Strains
Concept	Mice, Mutant Strains
Concept	Mice, Neurologic Mutants
Concept	Mice, Nude
Concept	Mice, Transgenic
Concept	Mice, SCID
Concept	Mice, Inbred NOD
Concept	Mice, Knockout
Concept	Mice, Congenic
Concept	Mice
Concept	Mice, 129 Strain
Academic Article	Fibroblast Growth Requires CT10 Regulator of Kinase (Crk) and Crk-like (CrkL).
Academic Article	Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma.
Academic Article	Crk proteins transduce FGF signaling to promote lens fiber cell elongation.
Academic Article	Astrocytes Promote Medulloblastoma Progression through Hedgehog Secretion.
Academic Article	Nestin Mediates Hedgehog Pathway Tumorigenesis.
Academic Article	CRK proteins selectively regulate T cell migration into inflamed tissues.
Academic Article	Crk and CrkL are required for cell transformation by v-fos and v-ras.
Academic Article	Dendritic planarity of Purkinje cells is independent of Reelin signaling.
Academic Article	Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis.
Academic Article	Essential roles of Crk and CrkL in fibroblast structure and motility.
Academic Article	Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse.
Academic Article	Absence of thyroid hormone receptor beta-retinoid X receptor interactions in auditory function and in the pituitary-thyroid axis.
Academic Article	A gene expression approach to mapping the functional maturation of the hippocampus.
Academic Article	Reelin regulates the development and synaptogenesis of the layer-specific entorhino-hippocampal connections.
Academic Article	Gene dosage in mice--BAC to the future.
Academic Article	Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1.
Academic Article	Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS.
Academic Article	Reelin is a ligand for lipoprotein receptors.
Academic Article	Dysfunctions in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R).
Academic Article	The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched.
Academic Article	Disabled-1 is expressed in type AII amacrine cells in the mouse retina.
Academic Article	Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.
Academic Article	Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1.
Academic Article	Audiogenic seizure susceptibility in thyroid hormone receptor beta-deficient mice.
Academic Article	Role of the reelin signaling pathway in central nervous system development.
Academic Article	The reelin pathway modulates the structure and function of retinal synaptic circuitry.
Academic Article	Disabled-1 interacts with a novel developmentally regulated protocadherin.
Academic Article	Brain development: integrins and the Reelin pathway.
Academic Article	Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice.
Academic Article	Methylation matters: modeling a manageable genome.
Academic Article	Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling.
Academic Article	Fos-Like Immunoreactivity Induced by Seizure in Mice Is Specifically Associated With Euchromatin in Neurons.
Academic Article	mPPP1R16B is a novel mouse protein phosphatase 1 targeting subunit whose mRNA is located in cell bodies and dendrites of neurons in four distinct regions of the brain.
Academic Article	Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1.
Academic Article	Cysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA binding.
Academic Article	Mouse embryos cloned from brain tumors.
Academic Article	Reovirus prolongs survival and reduces the frequency of spinal and leptomeningeal metastases from medulloblastoma.
Academic Article	Crystal structures of the Dab homology domains of mouse disabled 1 and 2.
Academic Article	Interaction of Disabled-1 and the GTPase activating protein Dab2IP in mouse brain.
Academic Article	Differential binding of ligands to the apolipoprotein E receptor 2.
Academic Article	A molecular fingerprint for medulloblastoma.
Academic Article	Components of the reelin signaling pathway are expressed in the spinal cord.
Academic Article	Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins.
Academic Article	Medulloblastoma and retinoblastoma: oncology recapitulates ontogeny.
Academic Article	Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.
Academic Article	A neurogenomics approach to gene expression analysis in the developing brain.
Academic Article	Gli1 is important for medulloblastoma formation in Ptc1+/- mice.
Academic Article	Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics.
Academic Article	Radial glia cells are candidate stem cells of ependymoma.
Academic Article	The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation.
Academic Article	BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Academic Article	Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies.
Academic Article	Developmental mouse brain gene expression maps.
Academic Article	Gene expression profiles of mouse retinas during the second and third postnatal weeks.
Academic Article	Patched2 modulates tumorigenesis in patched1 heterozygous mice.
Academic Article	Cardiovascular and craniofacial defects in Crk-null mice.
Academic Article	Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor.
Academic Article	Loss of suppressor-of-fused function promotes tumorigenesis.
Academic Article	Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality.
Academic Article	Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure.
Academic Article	Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling.
Academic Article	Cancer: Hedgehog's other great trick.
Academic Article	Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway.
Academic Article	Developmental expression of thyroid hormone receptor beta2 protein in cone photoreceptors in the mouse.
Academic Article	Ectopic expression of reelin alters migration of sympathetic preganglionic neurons in the spinal cord.
Academic Article	Mouse models and mouse supermodels.
Academic Article	Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor.
Academic Article	Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L.
Academic Article	PTHrP treatment fails to rescue bone defects caused by Hedgehog pathway inhibition in young mice.
Academic Article	The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress.
Academic Article	Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease.
Academic Article	Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity.
Academic Article	Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome.
Academic Article	The Ketogenic Diet Does Not Affect Growth of Hedgehog Pathway Medulloblastoma in Mice.
Academic Article	Generation of a mouse model of atypical teratoid/rhabdoid tumor of the central nervous system through combined deletion of Snf5 and p53.
Academic Article	Temporal and spatial expression of a fos-lacZ transgene in the developing nervous system.
Academic Article	Regulation of a fos-lacZ fusion gene: a paradigm for quantitative analysis of stimulus-transcription coupling.
Academic Article	Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase.
Academic Article	fos-lacZ transgenic mice: mapping sites of gene induction in the central nervous system.
Academic Article	Transcriptional activation and repression by Fos are independent functions: the C terminus represses immediate-early gene expression via CArG elements.
Academic Article	Regulation of proenkephalin by Fos and Jun.
Academic Article	Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure.
Academic Article	The structure and function of the fos proto-oncogene.
Academic Article	Glutamate receptor agonists increase the expression of Fos, Fra, and AP-1 DNA binding activity in the mammalian brain.
Academic Article	Extended life span and tumorigenicity of nonestablished mouse connective tissue cells transformed by the fos oncogene of FBR-MuSV.
Academic Article	Deletion of the gag region from FBR murine osteosarcoma virus does not affect its enhanced transforming activity.
Academic Article	Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene.
Academic Article	The fos gene product undergoes extensive post-translational modification in eukaryotic but not in prokaryotic cells.
Academic Article	Mapping patterns of c-fos expression in the central nervous system after seizure.
Academic Article	Microinjection of transforming ras protein induces c-fos expression.
Academic Article	Levels of fos, ets2, and myb proto-oncogene RNAs correlate with segregation of chromosome 11 of normal cells and with suppression of tumorigenicity in human cell hybrids.
Academic Article	Expression of c-fos in NIH3T3 cells is very low but inducible throughout the cell cycle.
Academic Article	Viral and cellular fos proteins are complexed with a 39,000-dalton cellular protein.
Academic Article	FBR murine osteosarcoma virus. I. Molecular analysis and characterization of a 75,000-Da gag-fos fusion product.
Academic Article	Identification of a 39,000-dalton protein in cells transformed by the FBJ murine osteosarcoma virus.
Academic Article	FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA.
Academic Article	Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini.
Academic Article	Structure of the FBJ murine osteosarcoma virus genome: molecular cloning of its associated helper virus and the cellular homolog of the v-fos gene from mouse and human cells.
Academic Article	Viral and cellular fos proteins: a comparative analysis.
Academic Article	Induction of c-fos gene and protein by growth factors precedes activation of c-myc.
Academic Article	Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein.
Academic Article	N-terminal variants of thyroid hormone receptor beta: differential function and potential contribution to syndrome of resistance to thyroid hormone.
Academic Article	Reeler gene discrepancies.
Academic Article	Apoptosis in the nervous system: new revelations.
Academic Article	A protein related to extracellular matrix proteins deleted in the mouse mutant reeler.
Academic Article	Fos: an immediate-early transcription factor in neurons.
Academic Article	Kainic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats.
Academic Article	Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements.
Academic Article	Design of a "minimAl" homeodomain: the N-terminal arm modulates DNA binding affinity and stabilizes homeodomain structure.
Academic Article	Isolation of an allele of reeler by insertional mutagenesis.
Academic Article	Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death.
Academic Article	Cell transformation by c-fos requires an extended period of expression and is independent of the cell cycle.
Academic Article	Isolation of the cyclosporin-sensitive T cell transcription factor NFATp.
Academic Article	The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun.
Academic Article	A fos-lac Z transgenic mouse that can be used for neuroanatomic mapping.
Academic Article	Continuous c-fos expression precedes programmed cell death in vivo.
Academic Article	Regulation of proto-oncogene expression in adult and developing lungs.
Academic Article	Phosphorylation of c-Fos at the C-terminus enhances its transforming activity.
Academic Article	An enhanced immune response in mice lacking the transcription factor NFAT1.
Academic Article	Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function.
Academic Article	Thyroid hormone receptor beta is essential for development of auditory function.
Academic Article	Selective activation of calcium permeability by aspartate in Purkinje cells.
Academic Article	Functional NMDA receptors are transiently active and support the survival of Purkinje cells in culture.
Academic Article	The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.
Academic Article	Detection of the reelin breakpoint in reeler mice.
Academic Article	c-Jun stimulates origin-dependent DNA unwinding by polyomavirus large Tantigen.
Academic Article	Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody.
Academic Article	The human reelin gene: isolation, sequencing, and mapping on chromosome 7.
Academic Article	Thyrotropin regulation by thyroid hormone in thyroid hormone receptor beta-deficient mice.
Academic Article	Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice.
Academic Article	Cerebellar disorganization characteristic of reeler in scrambler mutant mice despite presence of reelin.
Academic Article	Reeler: new tales on an old mutant mouse.
Academic Article	Role of reelin in the control of brain development.
Academic Article	Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain.
Academic Article	Leukotriene Synthesis Is Critical for Medulloblastoma Progression.
Academic Article	Requirement for Crk and CrkL during postnatal lens development.
Academic Article	Statins repress hedgehog signaling in medulloblastoma with no bone toxicities.
Academic Article	Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality.

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