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Search Results to J. Steven Leeder

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research overview In his former role as Director of the Division of Clinical Pharmacology and Therapeutic Innovation at Children’s Mercy Dr. Leeder led a program consisting of multidisciplinary teams of researchers with expertise in analytical chemistry, drug biotransformation, gene regulation, pharmacogenomics, and pharmacokinetics to investigate variability in medication response in children. An important component of the program was to provide an environment in which trainees and early career faculty members from diverse backgrounds could develop as independent investigators in their areas of research interest. These research interests generally are closely aligned with their clinical expertise with the goal of implementing precision therapeutics in their clinical subspecialties to benefit the patients they serve. Currently, Dr Leeder is Executive Director (Interim) of the Children’s Mercy Research Institute and leads the Precision Therapeutics Area of Emphasis. The Precision Therapeutics initiative extends the Division of Clinical Pharmacology's emphasis on developing individuals to a more institutional level by providing support to pediatric subspecialties interested in adding precision therapeutics to their portfolio of research programs. In this way the program serves as a model of integrated research that will extend throughout the CMRI. Over the years, Dr. Leeder's research interests in pediatric pharmacogenetics and the ontogeny of drug biotransformation pathways during growth and development have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids. Originally funded as one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development, "GOLDILOKs" now represents a conceptual approach to better understanding factors contributing to variability in drug disposition and response and using that information to make the use of medications safer and more effective in children of all ages. Dr. Leeder is also co-PI, with Dr. Mario Castro (KUMC), of the Frontiers Clinical and Translational Science Institute at the University of Kansas.

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item TypeName
Concept Gene Expression Regulation
Concept Down-Regulation
Concept Up-Regulation
Concept Gene Expression Regulation, Enzymologic
Concept Gene Expression Regulation, Developmental
Concept Government Regulation
Academic Article Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: insights into PXR-mediated gene regulation.
Academic Article Variability of CYP3A7 expression in human fetal liver.
Academic Article Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.
Academic Article Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants.
Academic Article Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.
Academic Article Selective Toll--like receptor expression in human fetal lung.
Academic Article Conference scene: pediatric pharmacogenomics and personalized medicine.
Academic Article Expression analysis of asthma candidate genes during human and murine lung development.
Academic Article Cotinine in human placenta predicts induction of gene expression in fetal tissues.
Academic Article Epigenetic regulation of ADME-related genes: focus on drug metabolism and transport.
Academic Article Glucocorticoid genes and the developmental origins of asthma susceptibility and treatment response.
Academic Article Tissue-specific expression and alternative splicing of human microsomal epoxide hydrolase.
Academic Article Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome.
Academic Article Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Academic Article Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.
Academic Article Decreased Pregnane X Receptor Expression in Children with Active Crohn's Disease.
Academic Article Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development.
Academic Article Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.
Academic Article Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver.

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