| Item Type | Name |
|
Concept
|
Acetaminophen
|
|
Concept
|
Acetylcysteine
|
|
Concept
|
Acetyltransferases
|
|
Concept
|
Acute-Phase Proteins
|
|
Concept
|
Adenosine Triphosphate
|
|
Concept
|
Adrenal Cortex Hormones
|
|
Concept
|
Adrenergic beta-Antagonists
|
|
Concept
|
Alcohol Dehydrogenase
|
|
Concept
|
Ethanol
|
|
Concept
|
Aldehyde Dehydrogenase
|
|
Concept
|
Aminoimidazole Carboxamide
|
|
Concept
|
Central Nervous System Stimulants
|
|
Concept
|
Analgesics
|
|
Concept
|
Analgesics, Opioid
|
|
Concept
|
Androgens
|
|
Concept
|
Androstadienes
|
|
Concept
|
Aniline Compounds
|
|
Concept
|
Antibodies, Anti-Idiotypic
|
|
Concept
|
Anti-Infective Agents
|
|
Concept
|
Anti-Infective Agents, Local
|
|
Concept
|
Anti-Infective Agents, Urinary
|
|
Concept
|
Anti-Inflammatory Agents
|
|
Concept
|
Anti-Ulcer Agents
|
|
Concept
|
Anti-Bacterial Agents
|
|
Concept
|
Antibiotics, Antineoplastic
|
|
Concept
|
Antibodies
|
|
Concept
|
Antibodies, Monoclonal
|
|
Concept
|
Anticoagulants
|
|
Concept
|
Anticonvulsants
|
|
Concept
|
Antidepressive Agents
|
|
Concept
|
Antiemetics
|
|
Concept
|
Antifungal Agents
|
|
Concept
|
Epitopes
|
|
Concept
|
Antigens
|
|
Concept
|
Antimetabolites
|
|
Concept
|
Antimetabolites, Antineoplastic
|
|
Concept
|
Antineoplastic Agents
|
|
Concept
|
Antioxidants
|
|
Concept
|
Antitussive Agents
|
|
Concept
|
Aryl Hydrocarbon Hydroxylases
|
|
Concept
|
Arylamine N-Acetyltransferase
|
|
Concept
|
Autoantibodies
|
|
Concept
|
Autoantigens
|
|
Concept
|
Baclofen
|
|
Concept
|
Base Sequence
|
|
Concept
|
Beclomethasone
|
|
Concept
|
Benzhydryl Compounds
|
|
Concept
|
Benzodiazepines
|
|
Concept
|
Binding Sites
|
|
Concept
|
Binding Sites, Antibody
|
|
Concept
|
Bronchodilator Agents
|
|
Concept
|
Buserelin
|
|
Concept
|
Caffeine
|
|
Concept
|
Calcium
|
|
Concept
|
Carbamazepine
|
|
Concept
|
Carbon Dioxide
|
|
Concept
|
Carbon Isotopes
|
|
Concept
|
Carboxylic Acids
|
|
Concept
|
Carboxylic Ester Hydrolases
|
|
Concept
|
Carrier Proteins
|
|
Concept
|
Catechol O-Methyltransferase
|
|
Concept
|
Ceftazidime
|
|
Concept
|
Cephalosporins
|
|
Concept
|
Ciprofloxacin
|
|
Concept
|
Cisplatin
|
|
Concept
|
Clotrimazole
|
|
Concept
|
Clozapine
|
|
Concept
|
Codeine
|
|
Concept
|
Contraceptive Agents
|
|
Concept
|
Contraceptives, Oral
|
|
Concept
|
Cotinine
|
|
Concept
|
Cytochrome P-450 Enzyme System
|
|
Concept
|
Cytosine
|
|
Concept
|
Debrisoquin
|
|
Concept
|
Deferoxamine
|
|
Concept
|
Dehydroepiandrosterone
|
|
Concept
|
Delayed-Action Preparations
|
|
Concept
|
Deuterium
|
|
Concept
|
Dexamethasone
|
|
Concept
|
Dextromethorphan
|
|
Concept
|
Dextrorphan
|
|
Concept
|
Dibenzazepines
|
|
Concept
|
Dicyclomine
|
|
Concept
|
Digoxin
|
|
Concept
|
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
|
|
Concept
|
Disulfides
|
|
Concept
|
Dithionitrobenzoic Acid
|
|
Concept
|
DNA
|
|
Concept
|
DNA, Fungal
|
|
Concept
|
DNA, Viral
|
|
Concept
|
Dosage Forms
|
|
Concept
|
Doxylamine
|
|
Concept
|
Drug Combinations
|
|
Concept
|
Pharmaceutical Preparations
|
|
Concept
|
Nonprescription Drugs
|
|
Concept
|
Environmental Pollutants
|
|
Concept
|
Enzyme Inhibitors
|
|
Concept
|
Enzymes
|
|
Concept
|
Epoxide Hydrolases
|
|
Concept
|
Erythromycin
|
|
Concept
|
Esterases
|
|
Concept
|
Ethanolamines
|
|
Concept
|
Ethinyl Estradiol
|
|
Concept
|
Exons
|
|
Concept
|
Expectorants
|
|
Concept
|
Factor V
|
|
Concept
|
Fatty Acids, Unsaturated
|
|
Concept
|
Ferredoxin-NADP Reductase
|
|
Concept
|
Fluoresceins
|
|
Concept
|
Fluorescent Dyes
|
|
Concept
|
Fluoxetine
|
|
Concept
|
Folic Acid
|
|
Concept
|
Folic Acid Antagonists
|
|
Concept
|
Gentamicins
|
|
Concept
|
Glucagon
|
|
Concept
|
Glucose
|
|
Concept
|
Glucuronates
|
|
Concept
|
Glutathione
|
|
Concept
|
Glutathione Reductase
|
|
Concept
|
Glutathione Transferase
|
|
Concept
|
Haptens
|
|
Concept
|
Heat-Shock Proteins
|
|
Concept
|
Histamine
|
|
Concept
|
Histamine Antagonists
|
|
Concept
|
HLA Antigens
|
|
Concept
|
Mixed Function Oxygenases
|
|
Concept
|
Hypnotics and Sedatives
|
|
Concept
|
Hypochlorous Acid
|
|
Concept
|
Immunoglobulin G
|
|
Concept
|
Imines
|
|
Concept
|
Immune Sera
|
|
Concept
|
Immunosuppressive Agents
|
|
Concept
|
Indoles
|
|
Concept
|
Indomethacin
|
|
Concept
|
Introns
|
|
Concept
|
Ionophores
|
|
Concept
|
Ions
|
|
Concept
|
Iron
|
|
Concept
|
Isoenzymes
|
|
Concept
|
Isoflavones
|
|
Concept
|
Isomerases
|
|
Concept
|
Ketoconazole
|
|
Concept
|
Peptidyl-Dipeptidase A
|
|
Concept
|
Lactones
|
|
Concept
|
Lidocaine
|
|
Concept
|
Cholesterol, LDL
|
|
Concept
|
Luciferases
|
|
Concept
|
Membrane Glycoproteins
|
|
Concept
|
Methionine Sulfoximine
|
|
Concept
|
Methotrexate
|
|
Concept
|
Methylamines
|
|
Concept
|
Methyltransferases
|
|
Concept
|
Metoprolol
|
|
Concept
|
Metronidazole
|
|
Concept
|
Microfilament Proteins
|
|
Concept
|
Midazolam
|
|
Concept
|
Mitogens
|
|
Concept
|
Morphine
|
|
Concept
|
Morpholines
|
|
Concept
|
Muscle Relaxants, Central
|
|
Concept
|
Peroxidase
|
|
Concept
|
NAD
|
|
Concept
|
NADP
|
|
Concept
|
NADPH-Ferrihemoprotein Reductase
|
|
Concept
|
Naltrexone
|
|
Concept
|
Naphthalenes
|
|
Concept
|
Narcotic Antagonists
|
|
Concept
|
Neoplasm Proteins
|
|
Concept
|
Nicotine
|
|
Concept
|
Nitriles
|
|
Concept
|
Nitrobenzoates
|
|
Concept
|
Norgestrel
|
|
Concept
|
Omeprazole
|
|
Concept
|
Oxidoreductases
|
|
Concept
|
Oxidoreductases, N-Demethylating
|
|
Concept
|
Oximes
|
|
Concept
|
Oxycodone
|
|
Concept
|
Oxygenases
|
|
Concept
|
Peptide Fragments
|
|
Concept
|
Phenethylamines
|
|
Concept
|
Phenobarbital
|
|
Concept
|
Phenols
|
|
Concept
|
Phenyl Ethers
|
|
Concept
|
Phenytoin
|
|
Concept
|
Phosphodiesterase Inhibitors
|
|
Concept
|
Pimozide
|
|
Concept
|
Pirenzepine
|
|
Concept
|
Plasmids
|
|
Concept
|
Polyglutamic Acid
|
|
Concept
|
Prilocaine
|
|
Concept
|
Promoter Regions, Genetic
|
|
Concept
|
Propylamines
|
|
Concept
|
Protein-Tyrosine Kinases
|
|
Concept
|
Proteins
|
|
Concept
|
Proto-Oncogene Proteins
|
|
Concept
|
Pteroylpolyglutamic Acids
|
|
Concept
|
Pulmonary Surfactants
|
|
Concept
|
Pyridines
|
|
Concept
|
Pyridoxine
|
|
Concept
|
Quinidine
|
|
Concept
|
Receptors, Steroid
|
|
Concept
|
Receptors, Virus
|
|
Concept
|
Recombinant Proteins
|
|
Concept
|
Ribonucleotides
|
|
Concept
|
RNA
|
|
Concept
|
RNA, Messenger
|
|
Concept
|
Serotonin
|
|
Concept
|
Stereoisomerism
|
|
Concept
|
Steroid Hydroxylases
|
|
Concept
|
Sulfamethoxazole
|
|
Concept
|
Sulfates
|
|
Concept
|
Sulfonamides
|
|
Concept
|
Teratogens
|
|
Concept
|
Testosterone
|
|
Concept
|
Tetrahydrofolates
|
|
Concept
|
Tetrazolium Salts
|
|
Concept
|
Theophylline
|
|
Concept
|
Thiazoles
|
|
Concept
|
Thromboxane-A Synthase
|
|
Concept
|
Tobramycin
|
|
Concept
|
Tramadol
|
|
Concept
|
Antipsychotic Agents
|
|
Concept
|
Anti-Anxiety Agents
|
|
Concept
|
Transcription Factors
|
|
Concept
|
Transferases
|
|
Concept
|
Triglycerides
|
|
Concept
|
Trimethoprim
|
|
Concept
|
Biomarkers, Tumor
|
|
Concept
|
Glucuronosyltransferase
|
|
Concept
|
Valproic Acid
|
|
Concept
|
Nasal Decongestants
|
|
Concept
|
Vitamin D
|
|
Concept
|
Vitamin K
|
|
Concept
|
Vitamins
|
|
Concept
|
Warfarin
|
|
Concept
|
Xanthenes
|
|
Concept
|
Xanthine Oxidase
|
|
Concept
|
Zidovudine
|
|
Concept
|
Sulfotransferases
|
|
Concept
|
Arylsulfotransferase
|
|
Concept
|
Xenobiotics
|
|
Concept
|
Citalopram
|
|
Concept
|
Drugs, Investigational
|
|
Concept
|
Trimethoprim, Sulfamethoxazole Drug Combination
|
|
Concept
|
Gene Library
|
|
Concept
|
Mifepristone
|
|
Concept
|
Minor Histocompatibility Antigens
|
|
Concept
|
Free Radical Scavengers
|
|
Concept
|
Cytokines
|
|
Concept
|
Benzoquinones
|
|
Concept
|
Tacrolimus
|
|
Concept
|
Bupropion
|
|
Concept
|
NAD(P)H Dehydrogenase (Quinone)
|
|
Concept
|
Fluvoxamine
|
|
Concept
|
Pravastatin
|
|
Concept
|
Paroxetine
|
|
Concept
|
Alternative Splicing
|
|
Concept
|
Receptors, Opioid, mu
|
|
Concept
|
DNA Primers
|
|
Concept
|
DNA, Complementary
|
|
Concept
|
Receptors, Cytoplasmic and Nuclear
|
|
Concept
|
Antirheumatic Agents
|
|
Concept
|
Antidepressive Agents, Second-Generation
|
|
Concept
|
Excitatory Amino Acid Antagonists
|
|
Concept
|
Antimanic Agents
|
|
Concept
|
Analgesics, Non-Narcotic
|
|
Concept
|
Adrenergic Uptake Inhibitors
|
|
Concept
|
Molecular Chaperones
|
|
Concept
|
CpG Islands
|
|
Concept
|
Anti-Allergic Agents
|
|
Concept
|
Anti-Asthmatic Agents
|
|
Concept
|
Anthracyclines
|
|
Concept
|
Hydroxymethylglutaryl-CoA Reductase Inhibitors
|
|
Concept
|
Buthionine Sulfoximine
|
|
Concept
|
Lactic Acid
|
|
Concept
|
Cytochrome P-450 CYP1A1
|
|
Concept
|
Cytochrome P-450 CYP1A2
|
|
Concept
|
Cytochrome P-450 CYP2D6
|
|
Concept
|
Cytochrome P-450 CYP2E1
|
|
Concept
|
Protein Disulfide-Isomerases
|
|
Concept
|
Intramolecular Oxidoreductases
|
|
Concept
|
Simvastatin
|
|
Concept
|
Protective Agents
|
|
Concept
|
Tyrphostins
|
|
Concept
|
Protein Isoforms
|
|
Concept
|
Tandem Repeat Sequences
|
|
Concept
|
Cisapride
|
|
Concept
|
Response Elements
|
|
Concept
|
Sertraline
|
|
Concept
|
Glucuronides
|
|
Concept
|
DNA, Ribosomal Spacer
|
|
Concept
|
Tacrolimus Binding Proteins
|
|
Concept
|
RNA Splice Sites
|
|
Concept
|
Mitochondrial Proteins
|
|
Concept
|
E-Box Elements
|
|
Concept
|
Membrane Transport Proteins
|
|
Concept
|
Organic Anion Transporters
|
|
Concept
|
Multidrug Resistance-Associated Proteins
|
|
Concept
|
Organic Cation Transporter 1
|
|
Concept
|
Organic Anion Transporters, Sodium-Independent
|
|
Concept
|
Soybean Proteins
|
|
Concept
|
Steroid 16-alpha-Hydroxylase
|
|
Concept
|
Aldehyde Oxidase
|
|
Concept
|
Methylenetetrahydrofolate Reductase (NADPH2)
|
|
Concept
|
Carboxylesterase
|
|
Concept
|
Retinoid X Receptors
|
|
Concept
|
Phytoestrogens
|
|
Concept
|
Serotonin Plasma Membrane Transport Proteins
|
|
Concept
|
Betaine-Homocysteine S-Methyltransferase
|
|
Concept
|
Wnt Proteins
|
|
Concept
|
Toll-Like Receptors
|
|
Concept
|
Toll-Like Receptor 2
|
|
Concept
|
Toll-Like Receptor 4
|
|
Concept
|
Aquaporin 1
|
|
Concept
|
Aquaporin 2
|
|
Concept
|
Cytochrome P-450 CYP3A
|
|
Concept
|
Hepatocyte Nuclear Factor 4
|
|
Concept
|
CCAAT-Enhancer-Binding Protein-delta
|
|
Concept
|
Oseltamivir
|
|
Concept
|
Janus Kinase 2
|
|
Concept
|
2-Pyridinylmethylsulfinylbenzimidazoles
|
|
Concept
|
Proton Pump Inhibitors
|
|
Concept
|
Nicotinamide Phosphoribosyltransferase
|
|
Concept
|
Lipocalins
|
|
Concept
|
Prescription Drugs
|
|
Concept
|
Antipyretics
|
|
Concept
|
Sulfonylurea Receptors
|
|
Concept
|
Vitamin K Epoxide Reductases
|
|
Concept
|
Cytochrome P-450 Enzyme Inhibitors
|
|
Concept
|
Cytochrome P-450 CYP1A2 Inhibitors
|
|
Concept
|
Cytochrome P-450 CYP1B1
|
|
Concept
|
Cytochrome P-450 CYP2A6
|
|
Concept
|
Cytochrome P-450 CYP2D6 Inhibitors
|
|
Concept
|
Cytochrome P-450 CYP3A Inhibitors
|
|
Concept
|
Cytochrome P-450 CYP2C9 Inducers
|
|
Concept
|
Cytochrome P-450 CYP2B6
|
|
Concept
|
Cytochrome P-450 CYP2C9
|
|
Concept
|
Cytochrome P-450 CYP2C19
|
|
Academic Article
|
Developmental and pediatric pharmacogenomics.
|
|
Academic Article
|
Developmental pharmacology--drug disposition, action, and therapy in infants and children.
|
|
Academic Article
|
Ontogeny of drug metabolizing enzymes in the neonate.
|
|
Academic Article
|
Assessment of the impact of renal impairment on systemic exposure of new molecular entities: evaluation of recent new drug applications.
|
|
Academic Article
|
Understanding the relative roles of pharmacogenetics and ontogeny in pediatric drug development and regulatory science.
|
|
Academic Article
|
Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.
|
|
Academic Article
|
Identifying genomic and developmental causes of adverse drug reactions in children.
|
|
Academic Article
|
The role of CYP3A4 mRNA transcript with shortened 3'-untranslated region in hepatocyte differentiation, liver development, and response to drug induction.
|
|
Academic Article
|
Interpreting pharmacogenetic data in the developing neonate: the challenge of hitting a moving target.
|
|
Academic Article
|
Age related changes in fractional elimination pathways for drugs: assessing the impact of variable ontogeny on metabolic drug-drug interactions.
|
|
Academic Article
|
Pharmacogenetics in pediatrics. Implications for practice.
|
|
Academic Article
|
Epigenetic regulation of ADME-related genes: focus on drug metabolism and transport.
|
|
Academic Article
|
Individualizing the use of medications in children: making Goldilocks happy.
|
|
Academic Article
|
Over-the-Counter Medications: Update on Cough and Cold Preparations.
|
|
Academic Article
|
Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development.
|
|
Academic Article
|
Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs.
|
|
Academic Article
|
Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future.
|
|
Academic Article
|
Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.
|
|
Academic Article
|
In: Antiepileptic Drugs, 5th Edition, Levy RH et al, (Eds.)
|
|
Grant
|
Ontogeny and Genetics of NSAID Dose-Exposure Relationship in Preterm Infants
|
|
Grant
|
Trimethoprim: an overlooked contributor of trimethoprim-sulfamethoxazole idiosyncratic adverse drug reactions
|
|
Academic Article
|
Recent advances in the ontogeny of drug disposition.
|
|
Academic Article
|
Ontogeny of Drug-Metabolizing Enzymes.
|
|
Grant
|
Ontogeny of drug transport
|
|
Grant
|
Effect of Obesity on Pantoprazole Pharmacokinetics and Pharmacodynamics in Children
|
|
Academic Article
|
Sex and the Kidney Drug-Metabolizing Enzymes and Transporters: Are Preclinical Drug Disposition Data Translatable to Humans?
|