Connection

Search Results to J. Steven Leeder

This is a "connection" page, showing the details of why an item matched the keywords from your search.

Search Results

Leeder, J. Steven

One or more keywords matched the following properties of Leeder, J. Steven

Property

Value

research overview

In his former role as Director of the Division of Clinical Pharmacology and Therapeutic Innovation at Children’s Mercy Dr. Leeder led a program consisting of multidisciplinary teams of researchers with expertise in analytical chemistry, drug biotransformation, gene regulation, pharmacogenomics, and pharmacokinetics to investigate variability in medication response in children. An important component of the program was to provide an environment in which trainees and early career faculty members from diverse backgrounds could develop as independent investigators in their areas of research interest. These research interests generally are closely aligned with their clinical expertise with the goal of implementing precision therapeutics in their clinical subspecialties to benefit the patients they serve. Currently, Dr Leeder is Executive Director (Interim) of the Children’s Mercy Research Institute and leads the Precision Therapeutics Area of Emphasis. The Precision Therapeutics initiative extends the Division of Clinical Pharmacology's emphasis on developing individuals to a more institutional level by providing support to pediatric subspecialties interested in adding precision therapeutics to their portfolio of research programs. In this way the program serves as a model of integrated research that will extend throughout the CMRI. Over the years, Dr. Leeder's research interests in pediatric pharmacogenetics and the ontogeny of drug biotransformation pathways during growth and development have coalesced into the GOLDILOKs initiative: Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids. Originally funded as one of four Specialized Centers for Research in Pediatric Developmental Pharmacology supported by the Eunice Kennedy Shriver National Institute for Child Health and Human Development, "GOLDILOKs" now represents a conceptual approach to better understanding factors contributing to variability in drug disposition and response and using that information to make the use of medications safer and more effective in children of all ages. Dr. Leeder is also co-PI, with Dr. Mario Castro (KUMC), of the Frontiers Clinical and Translational Science Institute at the University of Kansas.

One or more keywords matched the following items that are connected to Leeder, J. Steven

Item Type	Name
Concept	Adolescent
Concept	Child
Concept	Child Development
Concept	Child Health Services
Concept	Child, Preschool
Concept	Adolescent Development
Academic Article	Concordance between tramadol and dextromethorphan parent/metabolite ratios: the influence of CYP2D6 and non-CYP2D6 pathways on biotransformation.
Academic Article	The challenges of delivering pharmacogenomics into clinical pediatrics.
Academic Article	Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans.
Academic Article	Cytochrome P450 pharmacogenetics and anaesthesia.
Academic Article	Cisapride: a potential model substrate to assess cytochrome P4503A4 activity in vivo.
Academic Article	Developmental and pediatric pharmacogenomics.
Academic Article	A high-performance liquid chromatographic method for the measurement of deferoxamine in body fluids.
Academic Article	Developmental pharmacology--drug disposition, action, and therapy in infants and children.
Academic Article	Comparison of various urine collection intervals for caffeine and dextromethorphan phenotyping in children.
Academic Article	Translating pharmacogenetics and pharmacogenomics into drug development for clinical pediatrics and beyond.
Academic Article	Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.
Academic Article	Multiple dose pharmacokinetics of paroxetine in children and adolescents with major depressive disorder or obsessive-compulsive disorder.
Academic Article	Human anti-cytochrome P450 antibodies in aromatic anticonvulsant-induced hypersensitivity reactions.
Academic Article	Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype.
Academic Article	The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype.
Academic Article	A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma.
Academic Article	Understanding the relative roles of pharmacogenetics and ontogeny in pediatric drug development and regulatory science.
Academic Article	Analysis of intracellular methotrexate polyglutamates in patients with juvenile idiopathic arthritis: effect of route of administration on variability in intracellular methotrexate polyglutamate concentrations.
Academic Article	Impact of the CYP2C19*17 allele on the pharmacokinetics of omeprazole and pantoprazole in children: evidence for a differential effect.
Academic Article	Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.
Academic Article	The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response.
Academic Article	Identifying genomic and developmental causes of adverse drug reactions in children.
Academic Article	Conference scene: pediatric pharmacogenomics and personalized medicine.
Academic Article	Developmental variations in metabolic capacity of flavin-containing mono-oxygenase 3 in childhood.
Academic Article	Effects of valproic acid on organic acid metabolism in children: a metabolic profiling study.
Academic Article	Development of biomarkers to optimize pediatric patient management: what makes children different?
Academic Article	Red blood cell folate concentrations and polyglutamate distribution in juvenile arthritis: predictors of folate variability.
Academic Article	Comprehensive quantitative measurement of folate polyglutamates in human erythrocytes by ion pairing ultra-performance liquid chromatography/tandem mass spectrometry.
Academic Article	Interpreting pharmacogenetic data in the developing neonate: the challenge of hitting a moving target.
Academic Article	Pediatric pharmacogenomics: a systematic assessment of ontogeny and genetic variation to guide the design of statin studies in children.
Academic Article	Trends in adverse reactions to trimethoprim-sulfamethoxazole.
Academic Article	Fluticasone propionate pharmacogenetics: CYP3A4*22 polymorphism and pediatric asthma control.
Academic Article	Decreased expression of nicotinamide phosphoribosyltransferase in patients with juvenile idiopathic arthritis receiving methotrexate.
Academic Article	Variability of histamine pharmacodynamic response in children with allergic rhinitis.
Academic Article	Pharmacogenetics in pediatrics. Implications for practice.
Academic Article	Vitamin D related genes in lung development and asthma pathogenesis.
Academic Article	Urinary biomarkers of trimethoprim bioactivation in vivo following therapeutic dosing in children.
Academic Article	Drug metabolism for the paediatrician.
Academic Article	VKORC1 and CYP2C9 genotypes are predictors of warfarin-related outcomes in children.
Academic Article	Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy.
Academic Article	Reference intervals for urinary renal injury biomarkers KIM-1 and NGAL in healthy children.
Academic Article	Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters.
Academic Article	Effect of CYP3A5 genotype, steroids, and azoles on tacrolimus in a pediatric renal transplant population.
Academic Article	Individualizing the use of medications in children: making Goldilocks happy.
Academic Article	Folate depletion and increased glutamation in juvenile idiopathic arthritis patients treated with methotrexate.
Academic Article	Detection of an endogenous urinary biomarker associated with CYP2D6 activity using global metabolomics.
Academic Article	CYP3A isoforms in Ewing's sarcoma tumours: an immunohistochemical study with clinical correlation.
Academic Article	Effect of CYP3A5*3 on asthma control among children treated with inhaled beclomethasone.
Academic Article	Acetaminophen overdose with therapeutic intent.
Academic Article	Over-the-Counter Medications: Update on Cough and Cold Preparations.
Academic Article	Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Academic Article	Single dose, CYP2D6 genotype-stratified pharmacokinetic study of atomoxetine in children with ADHD.
Academic Article	Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.
Academic Article	Quantification of pravastatin acid, lactone and isomers in human plasma by UHPLC-MS/MS and its application to a pediatric pharmacokinetic study.
Academic Article	Decreased Pregnane X Receptor Expression in Children with Active Crohn's Disease.
Academic Article	Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.
Academic Article	Nicotinamide Phosphoribosyltransferase Attenuates Methotrexate Response in Juvenile Idiopathic Arthritis and In Vitro.
Academic Article	Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics.
Academic Article	Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development.
Academic Article	Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase.
Academic Article	Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver.
Academic Article	Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.
Academic Article	Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy.
Academic Article	Cost and Potential Avoidability of Antibiotic-Associated Adverse Drug Reactions in Children.
Academic Article	Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.
Academic Article	Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.
Academic Article	Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.
Academic Article	Glucuronidation in humans. Pharmacogenetic and developmental aspects.
Academic Article	Age- and Genotype-Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate-Glucuronosyltransferases in Human Liver.
Academic Article	Acetaminophen intoxication during treatment: what you don't know can hurt you.
Academic Article	Ceftazidime disposition in acute and stable cystic fibrosis.
Academic Article	Evaluation of serum theophylline concentrations following administration of sustained-release beads in applesauce to asthmatic preschool children.
Academic Article	Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.
Academic Article	Cerebrospinal fluid pharmacokinetics of tobramycin, ceftazidime, phenobarbitone and phenytoin in a child.
Academic Article	Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants.
Academic Article	Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity.
Academic Article	Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults.
Academic Article	Considerations for Implementing Precision Therapeutics for Children.
Academic Article	Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia.
Academic Article	Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.
Academic Article	A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents.
Academic Article	Optimized Renal Transporter Quantification by Using Aquaporin 1 and Aquaporin 2 as Anatomical Markers: Application in Characterizing the Ontogeny of Renal Transporters and Its Correlation with Hepatic Transporters in Paired Human Samples.
Academic Article	Pharmacokinetic characteristics of the gonadotropin-releasing hormone analog D-Ser(TBU)-6EA-10luteinizing hormone-releasing hormone (buserelin) after subcutaneous and intranasal administration in children with central precocious puberty.
Academic Article	Adverse drug reaction active surveillance: developing a national network in Canada's children's hospitals.
Academic Article	Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver.
Academic Article	Normalized Testosterone Glucuronide as a Potential Urinary Biomarker for Highly Variable UGT2B17 in Children 7-18 Years.
Academic Article	Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia.
Academic Article	The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites.
Academic Article	Recent advances in the ontogeny of drug disposition.
Academic Article	Are body surface area based estimates of liver volume applicable to children with overweight or obesity? An in vivo validation study.
Academic Article	Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver.
Academic Article	The Impact of Age and Genetics on Naltrexone Biotransformation.
Academic Article	The Impact of the CYP2D6 "Enhancer" Single Nucleotide Polymorphism on CYP2D6 Activity.
Academic Article	Interindividual Variability and Differential Tissue Abundance of Mitochondrial Amidoxime Reducing Component Enzymes in Humans.
Academic Article	Pediatric growth patterns in youth-onset type 2 diabetes mellitus: Implications for physiologically-based pharmacokinetic models.
Academic Article	Genomic answers for children: Dynamic analyses of >1000 pediatric rare disease genomes.
Academic Article	Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective.
Academic Article	A longitudinal study of cytochrome P450 2D6 (CYP2D6) activity during adolescence.
Academic Article	Ontogeny of Scaling Factors for Pediatric Physiologically Based Pharmacokinetic Modeling and Simulation: Cytosolic Protein Per Gram of Liver.
Academic Article	SLCO1B1 Genetic Variation Influence on Atorvastatin Systemic Exposure in Pediatric Hypercholesterolemia.

Search Criteria

Child Welfare