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Gaedigk, Andrea

One or more keywords matched the following items that are connected to Gaedigk, Andrea

Item Type	Name
Concept	Phenotype
Academic Article	Characterization of cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquine.
Academic Article	Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans.
Academic Article	Effect of sex and menstrual cycle phase on cytochrome P450 2C19 activity with omeprazole used as a biomarker.
Academic Article	CYP2D6 poor metabolizer status can be ruled out by a single genotyping assay for the -1584G promoter polymorphism.
Academic Article	Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".
Academic Article	Lack of weight-based dose dependency and intraindividual variability of omeprazole for CYP2C19 phenotyping.
Academic Article	Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension.
Academic Article	Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans.
Academic Article	CYP2D636 gene arrangements within the cyp2d6 locus: association of CYP2D636 with poor metabolizer status.
Academic Article	Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype.
Academic Article	The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype.
Academic Article	The CYP2D6 gene locus in South African Coloureds: unique allele distributions, novel alleles and gene arrangements.
Academic Article	Evaluation of a [13C]-dextromethorphan breath test to assess CYP2D6 phenotype.
Academic Article	Identification of a novel non-functional CYP2D6 allele, CYP2D6*69, in a Caucasian poor metabolizer individual.
Academic Article	Six-month, prospective, longitudinal, open-label caffeine and dextromethorphan phenotyping study in children with growth hormone deficiency receiving recombinant human growth hormone replacement.
Academic Article	CYP2D7-2D6 hybrid tandems: identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction.
Academic Article	Variability in drug metabolizing enzyme activity in HIV-infected patients.
Academic Article	Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations.
Academic Article	Assessment of activity levels for CYP2D61, CYP2D62, and CYP2D6*41 genes by population pharmacokinetics of dextromethorphan.
Academic Article	Genetic transmission of cytochrome P450 2D6 (CYP2D6) ultrarapid metabolism: implications for breastfeeding women taking codeine.
Academic Article	Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype.
Academic Article	Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism.
Academic Article	Introduction of the AmpliChip CYP450 Test to a South African cohort: a platform comparative prospective cohort study.
Academic Article	Characterization of the CYP2D6 gene locus and metabolic activity in Indo- and Afro-Trinidadians: discovery of novel allelic variants.
Academic Article	Polymorphisms in CYP2D6 may predict methamphetamine related heart failure.
Academic Article	Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity.
Academic Article	Challenges in CYP2D6 phenotype assignment from genotype data: a critical assessment and call for standardization.
Academic Article	Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population.
Academic Article	Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors.
Academic Article	Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population.
Academic Article	Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort.
Academic Article	CYP450 genotype and pharmacogenetic association studies: a critical appraisal.
Academic Article	Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.
Academic Article	Prediction of CYP2D6 phenotype from genotype across world populations.
Academic Article	NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations.
Academic Article	Comparison of three CYP2D6 probe substrates and genotype in Ghanaians, Chinese and Caucasians.
Academic Article	Quantification of intraindividual variability and the influence of menstrual cycle phase on CYP2D6 activity as measured by dextromethorphan phenotyping.
Academic Article	Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort.
Academic Article	Identification of the primary gene defect at the cytochrome P450 CYP2D locus.
Academic Article	Constellation: a tool for rapid, automated phenotype assignment of a highly polymorphic pharmacogene, CYP2D6, from whole-genome sequences.
Academic Article	Erratum: Constellation: a tool for rapid, automated phenotype assignment of a highly polymorphic pharmacogene, CYP2D6, from whole-genome sequences.
Academic Article	Dose dependency of dextromethorphan for cytochrome P450 2D6 (CYP2D6) phenotyping.
Academic Article	Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data.
Academic Article	Interethnic differences of drug-metabolizing enzymes.
Academic Article	Limitations of dextromethorphan N-demethylation as a measure of CYP3A activity.
Academic Article	Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".
Academic Article	Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group.
Academic Article	Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2C9 and Nonsteroidal Anti-Inflammatory Drugs.
Academic Article	Transfer learning enables prediction of CYP2D6 haplotype function.
Academic Article	Relationship between CYP2D6 genotype, activity score and phenotype in a pediatric Thai population treated with risperidone.
Academic Article	Identification of CYP2D6 Haplotypes that Interfere with Commonly Used Assays for Copy Number Variation Characterization.
Academic Article	CYP2D6 genotype and reduced codeine analgesic effect in real-world clinical practice.
Academic Article	CYP2D69 and 41: Does the Activity Value Assigned to these Alleles Need to be Reduced to more Accurately Predict Phenotype?
Academic Article	The Impact of the CYP2D6 "Enhancer" Single Nucleotide Polymorphism on CYP2D6 Activity.
Academic Article	Clinical pharmacogenomic testing and reporting: A technical standard of the American College of Medical Genetics and Genomics (ACMG).
Academic Article	A longitudinal study of cytochrome P450 2D6 (CYP2D6) activity during adolescence.
Academic Article	PharmVar Tutorial on CYP2D6 Structural Variation Testing and Recommendations on Reporting.

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