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Search Results to Erin M. Guest

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research overview Dr. Guest's research areas of focus are in leukemia in infants, cancer genomics, and cancer predisposition syndromes. She is the study chair for the National Cancer Institute sponsored Children's Oncology Group clinical trial for infants with acute lymphoblastic leukemia (ALL) and she leads the national task force on infant ALL. Dr. Guest collaborates with researchers around the world to discover and develop new, more effective therapies for infants with leukemia.

One or more keywords matched the following items that are connected to Guest, Erin

Item TypeName
Concept Leukemia
Concept Leukemia, Lymphocytic, Chronic, B-Cell
Concept Leukemia, Myeloid, Acute
Concept Myeloid-Lymphoid Leukemia Protein
Concept Precursor Cell Lymphoblastic Leukemia-Lymphoma
Concept Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Academic Article Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis.
Academic Article The super elongation complex family of RNA polymerase II elongation factors: gene target specificity and transcriptional output.
Academic Article Updates in the biology and therapy for infant acute lymphoblastic leukemia.
Academic Article Parental Perceptions of Obesity and Obesity Risk Associated With Childhood Acute Lymphoblastic Leukemia.
Grant Identifying biomarkers of relapse in infant acute lymphoblastic leukemia (ALL) through single cell sequencing
Grant Mechanisms of chemotherapy resistance in pediatric acute lymphoblastic leukemia (ALL) with MLL gene rearrangement (MLL-R)
Academic Article Desensitization to pegaspargase in children with acute lymphoblastic leukemia and lymphoblastic lymphoma.
Academic Article Treatment of children with relapsed and refractory acute lymphoblastic leukemia with mitoxantrone, vincristine, pegaspargase, dexamethasone, and bortezomib.
Academic Article Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study.
Academic Article Overcoming Wnt-?-catenin dependent anticancer therapy resistance in leukaemia stem cells.
Grant A multi-omics approach to overcome resistance in infant leukemia by identifying immune-therapy failure mechanisms
Academic Article Gemtuzumab Ozogamicin Improves Event-Free Survival and Reduces Relapse in Pediatric KMT2A-Rearranged AML: Results From the Phase III Children's Oncology Group Trial AAML0531.
Grant Centromeric DNA instability as a biomarker in Acute Lymphoblastic Leukemia
Academic Article Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell-like blasts in KMT2A-rearranged leukemia.
Grant Evaluating the Impact of Rare, Clinically Detected Germline Variants in MLL-AF4 Leukemia: A Bedside-to-Bench Translational Model of Infant ALL
Academic Article Outstanding outcomes in infants with KMT2A-germline acute lymphoblastic leukemia treated with chemotherapy alone: results of the Children's Oncology Group AALL0631 trial.
Academic Article Real-world use of tisagenlecleucel in infant acute lymphoblastic leukemia.
Academic Article Preclinical efficacy of azacitidine and venetoclax for infant KMT2A-rearranged acute lymphoblastic leukemia reveals a new therapeutic strategy.
Academic Article Racial and ethnic disparities in childhood and young adult acute lymphocytic leukaemia: secondary analyses of eight Children's Oncology Group cohort trials.
Academic Article Measurable Residual Disease and Fusion Partner Independently Predict Survival and Relapse Risk in Childhood KMT2A-Rearranged Acute Myeloid Leukemia: A Study by the International Berlin-Frankfurt-M?nster Study Group.
Academic Article Minimal residual disease predicts outcomes in KMT2A-rearranged but not KMT2A-germline infant acute lymphoblastic leukemia: Report from Children's Oncology Group study AALL0631.
Grant A CRISPR genetic screen in an induced pluripotent stem cell model to discover modifiers of therapy-related pediatric leukemia
Grant Induced pluripotent stem cell models for pediatric KMT2A-r leukemia development and discovery of targeted therapies

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  • Leukemia