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Search Results to Todd Bradley

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research overview Dr. Bradley's research group seeks to understand how immune responses are regulated and to use these tools to engineer immunity. Dysregulation of the immune system can result in an over-stimulated immune response as observed in allergy and autoimmune disorders, or a poor immune response that results in susceptibility to infection and cancer. Dr. Bradley uses genomic technologies to dissect the molecular and cellular mechanisms that shape the immune response and determine how human genetics impacts an individual immunity in order to identify biomarkers and pathways that can be targeted to improve immunotherapies and vaccines. Prior to joining Children's Mercy, Dr. Bradley was Director of Viral Genetic Analysis and Assistant Professor of Medicine at the Human Vaccine Institute at the Duke University Medical Center.

One or more keywords matched the following items that are connected to Bradley, Todd

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Concept HIV Infections
Academic Article Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development.
Academic Article Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved.
Academic Article Broadly Neutralizing Antibodies and the Development of Vaccines.
Academic Article Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.
Academic Article Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds.
Academic Article Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages.
Academic Article Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity.
Academic Article HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism.
Academic Article RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses.
Academic Article Single-Cell Analysis of Quiescent HIV Infection Reveals Host Transcriptional Profiles that Regulate Proviral Latency.
Academic Article HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers.
Academic Article Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope Immunization.
Academic Article Immune checkpoint modulation enhances HIV-1 antibody induction.
Academic Article RAB11FIP5-Deficient Mice Exhibit Cytokine-Related Transcriptomic Signatures.
Academic Article Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.
Academic Article The Impact of Prior Infection and Age on Antibody Persistence After Severe Acute Respiratory Syndrome Coronavirus 2 Messenger RNA Vaccine.
Academic Article Polyclonal Broadly Neutralizing Antibody Activity Characterized by CD4 Binding Site and V3-Glycan Antibodies in a Subset of HIV-1 Virus Controllers.
Grant Natural killer cell regulation of the germinal center HIV neutralizing antibody response
Grant Impact of Antibody Effector Function Diversity on Antiviral Activity In Situ
Grant Natural killer cell regulation of the germinal center HIV neutralizing antibody response
Academic Article Cross-reactive antibodies elicited to conserved epitopes on SARS-CoV-2 spike protein after infection and vaccination.
Academic Article Vaccination After SARS-CoV-2 Infection Increased Antibody Avidity Against the Omicron Variant Compared to Vaccination Alone.
Academic Article Effects of Prior Infection with SARS-CoV-2 on B Cell Receptor Repertoire Response during Vaccination.
Academic Article Single-cell analysis of immune cell transcriptome during HIV-1 infection and therapy.
Academic Article Host immunity associated with spontaneous suppression of viremia in therapy-na?ve young rhesus macaques following neonatal SHIV infection.

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