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Search Results to Todd Bradley

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research overview Dr. Bradley's research group seeks to understand how immune responses are regulated and to use these tools to engineer immunity. Dysregulation of the immune system can result in an over-stimulated immune response as observed in allergy and autoimmune disorders, or a poor immune response that results in susceptibility to infection and cancer. Dr. Bradley uses genomic technologies to dissect the molecular and cellular mechanisms that shape the immune response and determine how human genetics impacts an individual immunity in order to identify biomarkers and pathways that can be targeted to improve immunotherapies and vaccines. Prior to joining Children's Mercy, Dr. Bradley was Director of Viral Genetic Analysis and Assistant Professor of Medicine at the Human Vaccine Institute at the Duke University Medical Center.

One or more keywords matched the following items that are connected to Bradley, Todd

Item TypeName
Concept Humans
Concept Milk, Human
Concept env Gene Products, Human Immunodeficiency Virus
Academic Article Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development.
Academic Article Immunogenicity of NYVAC Prime-Protein Boost Human Immunodeficiency Virus Type 1 Envelope Vaccination and Simian-Human Immunodeficiency Virus Challenge of Nonhuman Primates.
Academic Article Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge.
Academic Article Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Academic Article Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved.
Academic Article Broadly Neutralizing Antibodies and the Development of Vaccines.
Academic Article Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.
Academic Article Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.
Academic Article Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds.
Academic Article Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity.
Academic Article HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism.
Academic Article Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.
Academic Article A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge.
Academic Article Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV.
Academic Article RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses.
Academic Article Single-Cell Analysis of Quiescent HIV Infection Reveals Host Transcriptional Profiles that Regulate Proviral Latency.
Academic Article HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers.
Academic Article Targeted selection of HIV-specific antibody mutations by engineering B cell maturation.
Academic Article Immune checkpoint modulation enhances HIV-1 antibody induction.
Academic Article Targeting Natural Killer Cells for Improved Immunity and Control of the Adaptive Immune Response.
Academic Article RAB11FIP5-Deficient Mice Exhibit Cytokine-Related Transcriptomic Signatures.
Academic Article Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy.
Academic Article A prognostic gene signature for predicting survival outcome in diffuse large B-cell lymphoma.
Academic Article Antibody Responses after a Single Dose of SARS-CoV-2 mRNA Vaccine.
Academic Article Protein/AS01B vaccination elicits stronger, more Th2-skewed antigen-specific human T follicular helper cell responses than heterologous viral vectors.
Academic Article Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.
Academic Article Cross-reactive antibody immunity against SARS-CoV-2 in children and adults.
Academic Article Humoral immune responses during SARS-CoV-2 mRNA vaccine administration in seropositive and seronegative individuals.
Academic Article Immune cell residency in the nasal mucosa may partially explain respiratory disease severity across the age range.
Academic Article The Impact of Prior Infection and Age on Antibody Persistence After Severe Acute Respiratory Syndrome Coronavirus 2 Messenger RNA Vaccine.
Academic Article Natural killer cells in liver transplantation: Can we harness the power of the immune checkpoint to promote tolerance?
Academic Article Polyclonal Broadly Neutralizing Antibody Activity Characterized by CD4 Binding Site and V3-Glycan Antibodies in a Subset of HIV-1 Virus Controllers.
Grant Impact of Antibody Effector Function Diversity on Antiviral Activity In Situ
Academic Article Cross-reactive antibodies elicited to conserved epitopes on SARS-CoV-2 spike protein after infection and vaccination.
Academic Article Vaccination After SARS-CoV-2 Infection Increased Antibody Avidity Against the Omicron Variant Compared to Vaccination Alone.
Academic Article Single-cell analysis of immune cell transcriptome during HIV-1 infection and therapy.
Academic Article Humoral and cellular response to the COVID-19 vaccine in immunocompromised children.
Academic Article The cellular and immunological dynamics of early and transitional human milk.
Academic Article Effect of continuous positive airway pressure on sleep structure in heart failure patients with central sleep apnea.
Academic Article Differing relationship of nocturnal fluid shifts to sleep apnea in men and women with heart failure.
Academic Article Host immunity associated with spontaneous suppression of viremia in therapy-na?ve young rhesus macaques following neonatal SHIV infection.
Academic Article Defining genetic diversity of rhesus macaque Fc? receptors with long-read RNA sequencing.

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  • Humans