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research overview Dr. Elin Grundberg completed her PhD (2006) in Molecular Medicine at Uppsala University, Sweden and following post-doctoral training at the McGill University and Genome Quebec Innovation Centre she joined Wellcome Trust Sanger institute in 2009 to lead the international MuTHER Consortium, which included developing a major resource of detailed genomics and epigenomics data from multiple disease-targeted tissues from twins. In 2012, she was appointed Tenure-Track Assistant Professor at the Department of Human Genetics at McGill University where her group was applying various next-generation sequencing approaches to understand genetic and epigenetic factors underlying complex disease susceptibility. Dr. Grundberg lead two CIHR team grants on this topic including the EpiTriO Consotium with partners in Canada and Europe. She held a Canada Research Chair (tier 2) in Disease Genomics and Epigenomics. In Oct 2017, Dr. Grundberg joined the faculty at Children’s Mercy Kansas City where she holds the Roberta D. Harding & William F. Bradley, Jr. Endowed Chair in Genomic Research. She is building a comprehensive research program leveraging international collaborations (King’s College London, UK; INSERM, France, Helmholtz Zentrum, Germany, McGill, Canada) as well as local collaborators (CM, UMKC, KUMC) for tissue-resources and methodologies essential for contemporary disease genomics and epigenomics. Research areas span genomics medicine applied in pediatric and adult populations including rare diseases, metabolic diseases, social and environmental health and perinatal/maternal health. Dr. Grundberg currently collaborates with a number of large international research consortia and is the author of over 75 scientific papers.

One or more keywords matched the following items that are connected to Grundberg, Elin

Item TypeName
Concept Genome, Human
Concept Genome
Concept Genome-Wide Association Study
Academic Article Targeted screening of cis-regulatory variation in human haplotypes.
Academic Article Population genomics in a disease targeted primary cell model.
Academic Article Tissue effect on genetic control of transcript isoform variation.
Academic Article Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.
Academic Article Global patterns of cis variation in human cells revealed by high-density allelic expression analysis.
Academic Article A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.
Academic Article An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.
Academic Article Hundreds of variants clustered in genomic loci and biological pathways affect human height.
Academic Article Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
Academic Article Assessment of gene-by-sex interaction effect on bone mineral density.
Academic Article Large-scale association analysis identifies new risk loci for coronary artery disease.
Academic Article An epigenome-wide association study of total serum immunoglobulin E concentration.
Academic Article Genetic risk factors for decreased bone mineral accretion in children with asthma receiving multiple oral corticosteroid bursts.
Academic Article Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.
Academic Article Population whole-genome bisulfite sequencing across two tissues highlights the environment as the principal source of human methylome variation.
Academic Article Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome.
Academic Article Dissecting features of epigenetic variants underlying cardiometabolic risk using full-resolution epigenome profiling in regulatory elements.
Academic Article A genome-wide approach to identifying novel-imprinted genes.
Academic Article Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
Academic Article Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes.
Academic Article Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.
Academic Article Human metabolic individuality in biomedical and pharmaceutical research.
Academic Article Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population.
Academic Article Impact of common variation in bone-related genes on type 2 diabetes and related traits.
Academic Article A comparison of the whole genome approach of MeDIP-seq to the targeted approach of the Infinium HumanMethylation450 BeadChip(®) for methylome profiling.
Academic Article The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue.
Academic Article Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure.
Academic Article Gene expression changes with age in skin, adipose tissue, blood and brain.
Academic Article Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements.
Academic Article Expression of phosphofructokinase in skeletal muscle is influenced by genetic variation and associated with insulin sensitivity.
Academic Article Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Academic Article Interrogating causal pathways linking genetic variants, small molecule metabolites, and circulating lipids.
Academic Article An atlas of genetic influences on human blood metabolites.
Academic Article Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
Academic Article Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.
Academic Article Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation.
Academic Article Whole-genome sequence-based analysis of thyroid function.
Academic Article Erratum: Whole-genome sequence-based analysis of thyroid function.
Academic Article Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis.
Academic Article Identification of Novel Loci Associated With Hip Shape: A Meta-Analysis of Genomewide Association Studies.
Academic Article An atlas of genetic influences on osteoporosis in humans and mice.
Academic Article Correction to: Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome.
Academic Article Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures.
Academic Article Capturing functional epigenomes for insight into metabolic diseases.
Academic Article Genomic answers for children: Dynamic analyses of >1000 pediatric rare disease genomes.
Academic Article Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers.

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