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Kulesa, Paul

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Dr. Kulesa is a quantitative developmental biologist. His expertise lies at the intersection between biology and mathematics. He collects multi-scale data and constructs models to explain complex biological phenomena such as collective cell migration —a process essential to development of the nervous system and disease. His research focuses on neural crest cell development and how mistakes in migration and patterning lead to human birth defects and disease. Neural crest cells are highly migratory embryonic cells in vertebrates —animals with backbones. Before joining Children’s Mercy, Dr. Kulesa was the founding Director of Imaging at the Stowers Institute for Medical Research. During his almost two decades at the Stowers Institute, he established an internationally recognized program in neural crest cell biology. While there, he trained students in techniques to study cell migration during vertebrate development, using neural crest and neural crest-derived cancer models. Following his work at the Stowers Institute, he was the Berthiaume Family Professor of Neuroscience at the University of Notre Dame

One or more keywords matched the following items that are connected to Kulesa, Paul

Item Type	Name
Concept	Developmental Biology
Concept	Gene Expression Regulation, Developmental
Academic Article	Comparative analysis of neural crest cell death, migration, and function during vertebrate embryogenesis.
Academic Article	Developmental imaging: Insights into the avian embryo.
Academic Article	Eph/ephrins and N-cadherin coordinate to control the pattern of sympathetic ganglia.
Academic Article	From segment to somite: segmentation to epithelialization analyzed within quantitative frameworks.
Academic Article	Melanoma revives an embryonic migration program to promote plasticity and invasion.
Academic Article	Multiscale mechanisms of cell migration during development: theory and experiment.
Academic Article	Gene profiling in the avian embryo using laser capture microdissection and RT-qPCR.
Academic Article	The neural crest and cancer: a developmental spin on melanoma.
Academic Article	Developmental imaging: the avian embryo hatches to the challenge.
Academic Article	Neural crest migration is driven by a few trailblazer cells with a unique molecular signature narrowly confined to the invasive front.
Academic Article	VEGF signals induce trailblazer cell identity that drives neural crest migration.
Academic Article	TrkB/BDNF signalling patterns the sympathetic nervous system.
Academic Article	Multidisciplinary approaches to understanding collective cell migration in developmental biology.
Academic Article	Angiopoietin 2 signaling plays a critical role in neural crest cell migration.
Academic Article	Resolving in vivo gene expression during collective cell migration using an integrated RNAscope, immunohistochemistry and tissue clearing method.
Academic Article	Predicting neuroblastoma using developmental signals and a logic-based model.
Academic Article	Manipulation of Developmental Function in Turtles with Notes on Alligators.
Academic Article	In Ovo Electroporation of Plasmid DNA and Morpholinos into Specific Tissues During Early Embryogenesis.
Academic Article	Correction to: Manipulation of Developmental Function in Turtles with Notes on Alligators.

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Developmental